Navigation Links
UC Davis team 'spikes' stem cells to generate myelin
Date:8/28/2013

(SACRAMENTO, Calif.) Stem cell technology has long offered the hope of regenerating tissue to repair broken or damaged neural tissue. Findings from a team of UC Davis investigators have brought this dream a step closer by developing a method to generate functioning brain cells that produce myelin a fatty, insulating sheath essential to normal neural conduction.

"Our findings represent an important conceptual advance in stem cell research," said Wenbin Deng, principal investigator of the study and associate professor at the UC Davis Department of Biochemistry and Molecular Medicine. "We have bioengineered the first generation of myelin-producing cells with superior regenerative capacity."

The brain is made up predominantly of two cell types: neurons and glial cells. Neurons are regarded as responsible for thought and sensation. Glial cells surround, support and communicate with neurons, helping neurons process and transmit information using electrical and chemical signals. One type of glial cell the oligodendrocyte produces a sheath called myelin that provides support and insulation to neurons. Myelin, which has been compared to insulation around electrical wires that helps to prevent short circuits, is essential for normal neural conduction and brain function; well-recognized conditions involving defective myelin development or myelin loss include multiple sclerosis and leukodystrophies.

In this study, the UC Davis team first developed a novel protocol to efficiently induce embryonic stem cells (ESCs) to differentiate into oligodendroglial progenitor cells (OPCs), early cells that normally develop into oligodendrocytes. Although this has been successfully done by other researchers, the UC Davis method results in a purer population of OPCs, according to Deng, with fewer other cell types arising from their technique.

They next compared electrophysiological properties of the derived OPCs to naturally occurring OPCs. Th
'/>"/>

Contact: Charles Casey
charles.casey@ucdmc.ucdavis.edu
916-734-9048
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis researchers discover molecular target for the bacterial infection brucellosis
2. UC Davis study deflates notion that pear-shaped bodies more healthy than apples
3. UC Davis researchers aid effort to sequence the complex wheat genome
4. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
5. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
6. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
7. Why are some cells more cancer prone?
8. Harvard Stem Cell researchers create cells that line blood vessels
9. UCI-led study reveals how SARS virus hijacks host cells
10. Fetal tissue-derived stem cells may be ideal source for repairing tissues and organs
11. Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... in New Mexico, nearly every public golf course is ... potable water supplies. Across the U.S. Southwest as a ... treated effluent. Reusing the effluent increases the sustainability of ... alike fertilize their lawns during the growing season. The ... State University turfgrass expert has a new vision for ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
(Date:7/10/2014)... SPRINGS, Florida , July 1, 2014 ... wallets pave way for convenience and improved security: NXT-ID, Inc. ... Inc. (NASDAQ: GOOG ), Apple Inc. (NASDAQ: ... and MasterCard Corporation (NYSE: MA) NXT-ID, Inc., (OTCQB: NXTD) ... is pleased to announce that the second series of 30 ...
Breaking Biology News(10 mins):'Tailored' water -- the latest in lawn care 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5
... The old balkanized approach to ocean management, in which ... and administered by different agencies, has failed to protect ... panel of international scientists says, and should be replaced ... The panel, organized by scientists from Duke University, ...
... new and cleaner ways to meet the country,s energy ... new fuel source. The approach has the potential to ... contributing to rural economic development and lowering greenhouse emissions. ... volumes of diesel and jet transportation fuels. One of ...
... new paper by researchers at George Mason University and the ... between the diversity of organisms at the bottom of the ... Mark D. Uhen, a geologist at Mason, says that ... of whale species living at any given time period correlates ...
Cached Biology News:Marine spatial planning: A more balanced approach to ocean management 2Marine spatial planning: A more balanced approach to ocean management 3Marine spatial planning: A more balanced approach to ocean management 4Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 2Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 3Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 4New study finds link between marine algae and whale diversity over time 2
(Date:7/13/2014)... 13, 2014 2014 Deep Research Report ... professional and in-depth study on the current state of ... The report provides a basic overview of the industry, ... analysis and Chinese domestic market analysis are provided with ... of the market. A comparison between the international and ...
(Date:7/11/2014)... , Not for release, publication or distribution (in whole ... to do so would constitute a violation of the relevant ... the "Company") (LSE: SHP, NASDAQ: SHPG ) notes ... a meeting with representatives of AbbVie. This statement ... approval of AbbVie. A further update will be ...
(Date:7/11/2014)... -- EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is to ... The new Wyss Center for Bio- and ... , has named as its director one of ... , founder of Brown University,s Institute for Brain Science, ...
(Date:7/11/2014)... 11, 2014 Cayenne Medical, Inc., ... in the soft tissue reconstruction segment, announced the ... for surgeries involving the shoulder and extremities. The ... novel, inserter-controlled deployment method. The unique delivery eliminates ... anchor pull-out, or anchor displacement (also commonly know ...
Breaking Biology Technology:2014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3Shire plc - Statement re: Media Speculation 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3
... Chromatography and Mass Spectrometry Application Report , ... Shieh, Thermo Electron Corporation, San Jose, CA , ... Use of LC/MS n has experienced a dramatic ... screening to ADME/Tox studies. The Finnigan LCQ series ion trap mass spectrometers ...
... , Larry Simonson and Lynn ... Life Sciences Inc, Applications Laboratory, Hopkinton, Massachusetts, USA , ... Initially, work in 96 well microplates was commonly ... of plate processing has grown, automated liquid handling has become a ...
... Geoffrey Grove, Susan Ryan and Ed Alderman ... Technology Department, Caliper Life Sciences, Inc., Hopkinton, MA 01748 , ... The High Volume Head is one of four ... The architecture of the device includes an array of 96 pistons, which ...
Cached Biology Technology:Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 2Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 3Use of On-line Size Exclusion Chromatography (SEC) for Sample Clean-up in LC/MS Analyses 4384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 2384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 3384 Well Pipetting Precision and Accuracy Testing Using the Sciclone Advanced Liquid Handler 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 2Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 3Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 4Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 5Sciclone ALH 3000 Liquid Handler: Functional Characterization of the High Volume Head - Part 1: Plate-to-Plate Precision Testing 6
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. ID clarifier: ...
... other fluid sources for 8 vessels while ... each individual pump is controlled electronically. Both, ... maintained. ,High-precision controlled miniature pumps can ... allows flow rates between 0 and 420 ...
The Mu-End™ Protein Truncation Kit provides a convenient method for generating a library of N-terminal and C-terminal protein deletions that can be expressed in E. coli....
... The loxP-amp-loxP cassette is ... cells. The prokaryotic promoter gb2 driving ... slightly modified version of the Em7 promoter. ... generally used Tn5 promoter. A synthetic polyadenylation ...
Biology Products: