Navigation Links
UC Davis study deflates notion that pear-shaped bodies more healthy than apples
Date:1/10/2013

(SACRAMENTO, Calif.) People who are "apple-shaped" with fat more concentrated around the abdomen have long been considered more at risk for conditions such as heart disease and diabetes than those who are "pear-shaped" and carry weight more in the buttocks, hips and thighs.

But new research conducted at UC Davis Health System published in The Journal of Clinical Endocrinology and Metabolism provides further evidence that the protective benefits of having a pear-body shape may be more myth than reality. The journal article posted online January 10 and will appear in the March 2013 print edition.

The UC Davis study found that fat stored in the buttock area also known as gluteal adipose tissue secretes abnormal levels of chemerin and omentin-1, proteins that can lead to inflammation and a prediabetic condition know as insulin resistance in individuals with early metabolic syndrome.

Metabolic syndrome refers to a group of risk factors that occur together, doubling the risk for heart disease and increasing the risk for diabetes at least five-fold. Risk factors include having a large waistline, low levels of high-density lipoproteins (HDL), or "good" cholesterol, high blood pressure as well as high fasting blood sugar ( insulin resistance) and high triglyceride levels. According to the Centers for Disease Control and Prevention, metabolic syndrome affects 35 percent of American adults over age 20.

"Fat in the abdomen has long been considered the most detrimental to health, and gluteal fat was thought to protect against diabetes, heart disease and metabolic syndrome," said Ishwarlal Jialal, lead author of the study and a professor of pathology and laboratory medicine and of internal medicine at UC Davis. "But our research helps to dispel the myth that gluteal fat is 'innocent.' It also suggests that abnormal protein levels may be an early indicator to identify those at risk for developing metabolic syndrome."

The UC Davis team found that in individuals with early metabolic syndrome, gluteal fat secreted elevated levels of chemerin and low levels of omentin-1 proteins that correlate with other factors known to increase the risk for heart disease and diabetes. High chemerin levels, for example, correlated with high blood pressure, elevated levels of C-reactive protein (a sign of inflammation) and triglycerides, insulin resistance, and low levels of HDL cholesterol. Low omentin-1 levels correlated with high levels of triglycerides and blood glucose levels and low levels of HDL cholesterol.

"High chemerin levels correlated with four of the five characteristics of metabolic syndrome and may be a promising biomarker for metabolic syndrome," said Jialal. "As it's also an indicator of inflammation and insulin resistance, it could also emerge as part of a biomarker panel to define high-risk obesity states. The good news is that with weight loss, you can reduce chemerin levels along with the risk for metabolic syndrome."

To conduct the study, Jialal and colleagues recruited 45 patients with early metabolic syndrome defined as having at least three risk factors for metabolic syndrome including central obesity, hypertension, mild increases in glucose levels not yet in the diabetic range (<126 mg/dl), hyperlipidemia without cardiovascular disease or diabetes. A control group of 30 subjects had less than two risk factors for metabolic syndrome, with normal glucose and triglyceride levels. Both groups were matched for gender and age.

Complete blood counts, lipid profiles and blood glucose, blood pressure and C-reactive protein levels were measured in all participants. Levels of four proteins secreted by adipose tissue chemerin, resistin, visfatin and omentin-1 were also measured in plasma and in subcutaneous fat samples from gluteal tissue.

The researchers found that chemerin levels were increased and omentin-1 levels were decreased in both plasma and gluteal fat of subjects with metabolic syndrome compared to those in the control group. The abnormal levels of these two proteins were also independent of age, body mass index and waist circumference.

"Future large epidemiological studies should focus on evaluating the role of chemerin as a biomarker for the development of diabetes and cardiovascular disease in metabolic syndrome," Jialal said.


'/>"/>

Contact: Carole Gan
carole.gan@ucdmc.ucdavis.edu
916-734-9047
University of California - Davis Health System
Source:Eurekalert

Related biology news :

1. UC Davis researchers aid effort to sequence the complex wheat genome
2. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
3. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
4. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
5. Rhythms in the brain help give a sense of location, study shows
6. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
7. New study identifies significance of co-infection in disease control
8. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
9. Major cuts to surging CO2 emissions are needed now, not down the road, study finds
10. International study suggests human genes influence gut microbial composition
11. New study defines the long-sought structure of a protein necessary for cell-cell interaction
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2017)... March 27, 2017  Catholic Health Services (CHS) ... Systems Society (HIMSS) Analytics for achieving Stage 6 ... sm . In addition, CHS previously earned a ... using an electronic medical record (EMR). ... level of EMR usage in an outpatient setting.  ...
(Date:3/23/2017)... PUNE, India , March 23, 2017 The report ... Equipment, Touchless Biometric), Industry, and Geography - Global Forecast to 2022", published by ... growing at a CAGR of 29.63% between 2017 and 2022. ... ... Logo ...
(Date:3/22/2017)... 2017 Optimove , provider of ... such as 1-800-Flowers and AdoreMe, today announced two ... Replenishment. Using Optimove,s machine learning algorithms, these features ... replenishment recommendations to their customers based not just ... customer intent drawn from a complex web of ...
Breaking Biology News(10 mins):
(Date:9/19/2017)... , ... September 19, 2017 , ... ... largest group of funded early-stage tech companies. “Grit” author Angela Duckworth and her ... joining the ic@3401 community is Cooley, an international law firm with decades of ...
(Date:9/19/2017)... ... 2017 , ... The new and improved Oakton® pocket testers, from Cole-Parmer, stand ... with a new cap design that is versatile, functional and leakproof. They are ideal ... test water quality. , The Oakton pocket testers have many user-friendly and functional features. ...
(Date:9/19/2017)... , Sept. 19, 2017 ValGenesis Inc., ... (VLMS) is pleased to announce the strategic partnership with ... provide clients with validation services using the latest technology ... VTI will provide clients with efficient and cost-effective validation ... marketing partner for the ValGenesis VLMS system. ...
(Date:9/19/2017)... ... 2017 , ... Molecular Devices, LLC, a leader in protein ... the CloneSelect™ Single-Cell Printer™ in North America. This novel system utilizes sophisticated ... documentation of monoclonality for use in cell line development. , Clonal cell ...
Breaking Biology Technology: