Navigation Links
UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
Date:4/1/2009

(SACRAMENTO, Calif.) New research from UC Davis Cancer Center shows that a protein called Muc4 may be the essential ingredient that allows breast cancer to spread to other organs and resist therapeutic treatment. The study, which appears in the April 1 issue of Cancer Research, is one of the first to characterize the role of Muc4 in the disease.

Kermit Carraway, senior author of the study, knew that Muc4 was not always expressed in primary breast cancer tumors, yet it could be present in lymph node metastases. He suspected that it may have a specialized function in the process of metastasis.

"Breast cancer deaths are caused by metastasis, not by the primary tumor," explained Carraway, an associate professor of biochemistry and molecular medicine. "It's at that point that the disease also becomes difficult to treat. We think that Muc4 may be packing a one-two punch by promoting the release of breast cancer cells from the primary tumor and then inhibiting their death."

Muc4 is member of a group of proteins called mucins, which are commonly found in fluids such as tears and mucus. They have a known role in protecting epithelial cells, from which breast cancer cells are derived. When separated from their surrounding cell matrix, epithelial cells tend to die. Metastasizing breast cancer cells, however, can survive this detachment.

"Because breast cancer cells can lose their adhesive properties and still thrive, we suspected that Muc4 may be somehow allowing them to leave their cellular framework, travel to secondary sites and withstand treatment," Carraway explained.

To test his suspicions, Carraway and his team conducted two experiments. They started by comparing breast cancer cells that express Muc4 with those for which Muc4 production is blocked. The researchers then exposed both types of cells to chemotherapy drugs. The Muc4-producing cells survived.

They repeated the experiment with breast cancer cel
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis bench-to-bedside research: Promising treatment in clinical trials
2. UC Davis research shows that newly discovered drug reduces heart enlargement
3. UC Davis researchers find molecule that targets brain tumors
4. UC Davis discovery offers hope for treating kidney cancer
5. UC Davis team refines cancer treatments to reduce potential nerve damage
6. UC Davis researchers exploring gene therapy to fight AIDS
7. UC Davis researchers discover Achilles heel in pancreatic cancer
8. UC Davis researchers discover a key to aggressive breast cancer
9. UC Davis chemical ecologist wins major award
10. UC Davis researchers discover new drug target for inflammatory disease
11. UC Davis researchers define characteristics, treatment options for XXYY syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... potential effects of climate change on the world,s ... wrong factors, according to a new paper by ... University of Queensland, and other organizations. The authors ... missing the point when it comes to climate ... change scientists focus on the "direct" threats of ...
(Date:7/30/2014)... Society of America (ESA) has elected ten new Fellows ... Fellow acknowledges outstanding contributions to entomology in one or ... The following Fellows will be recognized during Entomology 2014 ... held November 16-19, 2014 in Portland, Oregon. , ... the Department of Plant, Soil and Entomological Sciences at ...
(Date:7/30/2014)... joint venture between The University of Texas at San ... Center at San Antonio, has selected the winners of ... from UTSA and Lei Huang from the Health Science ... engineered ferritins for tracking and protecting neural stem cells ... focused on finding a treatment for stroke through stem ...
Breaking Biology News(10 mins):Conservation scientists asking wrong questions on climate change impacts on wildlife 2Entomological Society of America recognizes 2014 fellows 2Entomological Society of America recognizes 2014 fellows 3Entomological Society of America recognizes 2014 fellows 4Entomological Society of America recognizes 2014 fellows 5Entomological Society of America recognizes 2014 fellows 6Entomological Society of America recognizes 2014 fellows 7Entomological Society of America recognizes 2014 fellows 8Entomological Society of America recognizes 2014 fellows 9Entomological Society of America recognizes 2014 fellows 10Entomological Society of America recognizes 2014 fellows 11Entomological Society of America recognizes 2014 fellows 12Entomological Society of America recognizes 2014 fellows 13Entomological Society of America recognizes 2014 fellows 14Entomological Society of America recognizes 2014 fellows 15Entomological Society of America recognizes 2014 fellows 16Entomological Society of America recognizes 2014 fellows 17
... March 1 issue of G&D, Dr. Christopher Fasano (Memorial ... into the effective generation of neural stem cells outside ... demonstrates that the polycomb group protein, Bmi-1, maintains forebrain ... and embryonic forebrain neural progenitor cells increases stem cell ...
... since insects developed a taste for vegetation, plants have ... their neighbors for light to grow, or, invest directly ... of scientists at the Salk Institute for Biological Studies ... a la Agronoma (IFEVA) has discovered how plants weigh ...
... immunodeficiency virus (HIV) adapts so well to the body,s ... pace with the ever-changing immunological profile of the virus, ... Birmingham (UAB) and the University of Oxford in England. ... adapt by spelling out at least 14 different "escape ...
Cached Biology News:Understanding natural crop defenses 2Understanding natural crop defenses 3HIV adapts to 'escape' immune response 2
(Date:7/30/2014)... (PRWEB) July 30, 2014 While ... in health services research for a relatively long ... in interest regarding the use of these ‘big ... conditions. , By combining today’s powerful computer technology ... digital era, ‘big data’ holds significant promise for ...
(Date:7/30/2014)... With the accelerated aging of ... expenditure as well as the improved medical care ... reagent industry has been developing quickly, especially in ... Chinese in vitro diagnostics market size reached RMB22.98 ... vitro diagnostic reagents. , Read complete report ...
(Date:7/30/2014)... AZ (PRWEB) July 30, 2014 ... State-of-the-art facility and complementary therapies brings comprehensive cancer ... foot, state-of-the-art Yuma Regional Cancer Center has officially ... 2012, the program includes services such as open, ... massage therapy, American Cancer Society Resource Center, hematology, ...
(Date:7/30/2014)...   Epic Sciences, Inc. ("Epic"), a private ... personalize and advance the treatment and management of cancer, ... as chairman of Epic,s board of directors. Mr. ... (formerly Invitrogen). Mr. Lucier joins Epic,s board of directors ... cell analysis platform with special focus on the development ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
... the University of Helsinki, Finland, has succeeded in producing ... is reduced to a nano-scale (one nanometre being one ... undergo substantial changes. Unlike in bulk materials, in nanoparticles ... the number of atoms inside the material, which, among ...
... Corporation (Amex: ETC ) ("ETC" or ... will be exhibiting at the upcoming APWCA 2009 ... (APWCA) 2009 National Conference will be held April ... Philadelphia, Center City. The APWCA provides cutting-edge education ...
... Portfolio LAKE FOREST, Ill., March 16 ... equity firm focused exclusively on the healthcare ... CorePharma LLC ("CorePharma") has completed the acquisition ... Leucovorin Calcium tablets are the generic equivalent ...
Cached Biology Technology:Paper electrified by copper particles 2Environmental Tectonics Corporation Announces Participation at APWCA National Conference 2Environmental Tectonics Corporation Announces Participation at APWCA National Conference 3RoundTable Healthcare Partners Facilitates Product Acquisition for CorePharma 2
Request Info...
Form: Ready to use Applications: ELISA...
... supports that retain stiffness in liquids, protect ... segments on each strip have chemically bonded ... charts provide clear comparison. Full-range strips (0 ... packs of 100; each strip is approximately ...
... Bench-Top Open System Chemistry Analyzer for General Chemistries, Specialty Chemistries, QC, Reagent Development, Pharmaceutical ... grating, diode spectrophotometer over 30 user-selectable wavelengths. ... ... ...
Biology Products: