Navigation Links
UC Davis researchers find molecule that targets brain tumors
Date:12/29/2008

(SACRAMENTO, Calif.) UC Davis Cancer Center researchers report today the discovery of a molecule that targets glioblastoma, a highly deadly form of cancer. The finding, which is published in the January 2009 issue of the European Journal of Nuclear Medicine and Molecular Imaging, provides hope for effectively treating an incurable cancer.

Glioblastoma is the most common and aggressive type of primary brain tumor in adults. It is marked by tumors with irregular shapes and poorly defined borders that rapidly invade neighboring tissues, making them difficult to remove surgically.

"These brain tumors are currently treated with surgery to remove as much of the tumor as possible followed by radiation to kill cancer cells left behind and systemic chemotherapy to prevent spread to nearby tissues," said Kit Lam, senior author of the study and UC Davis chief of hematology and oncology. "It is unfortunate that this approach does not extend survival significantly. Most patients survive less than one year."

To find new options for treating the disease, Lam and his colleagues began searching for a molecule that could be injected into a patient's bloodstream and deliver high concentrations of medication or radionuclides directly to brain tumor cells while sparing normal tissues. Through their study, they identified a molecule called LXY1 that binds with high specificity to a particular cell-surface protein called alpha-3 integrin, which is overexpressed on cancer cells.

They also tested the molecule's ability to target brain cancer by implanting human glioblastoma cells both beneath the skin and in the brains of mice. The researchers injected the mice with a radiolabeled version of LXY1 and, using near-infrared fluorescence imaging, showed that the molecule did preferentially bind to human glioblastoma cells in both locations.

"This outcome gives us great hope that we will be able to deliver targeted therapies to treat glioblastoma," said Lam.

Lam is planning to continue this work by repeating the experiments with powerful cancer treatments linked to the LXY1 molecule. They will begin with iodine-131, a form of radionuclide currently used to treat some cancers, as well as a nanoparticle, or "smart bomb," that would carry cancer-fighting drugs to diseased cells.


'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. UC Davis discovery offers hope for treating kidney cancer
2. UC Davis team refines cancer treatments to reduce potential nerve damage
3. UC Davis researchers exploring gene therapy to fight AIDS
4. UC Davis researchers discover Achilles heel in pancreatic cancer
5. UC Davis researchers discover a key to aggressive breast cancer
6. UC Davis chemical ecologist wins major award
7. UC Davis researchers discover new drug target for inflammatory disease
8. UC Davis researchers define characteristics, treatment options for XXYY syndrome
9. UC Davis researcher leads climate-change discovery
10. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
11. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:8/14/2017)... ... August 14, 2017 , ... Every year, ... researchers in the antibody community have recently come together to address this antibody ... the laboratory. , The team at Thermo Fisher Scientific ...
(Date:8/11/2017)... ... August 11, 2017 , ... A staple in the community for ... will incorporate important key elements including a new digital marketing strategy and updated logo. ... them, Bill Miller has partnered with the South Texas Blood & Tissue Center for ...
(Date:8/10/2017)... ... August 09, 2017 , ... ... next week-- as students. From August 14th through the 16th, the University City ... debuted in the summer of 2016, provides Philadelphia-based middle school educators an opportunity ...
(Date:8/10/2017)... (PRWEB) , ... August 09, 2017 , ... ... with four international biomedical optics laboratories — the Wellman Center for Photomedicine, the ... Laser Center Lübeck and the Beckman Laser Institute at University of California, Irvine ...
Breaking Biology Technology: