Navigation Links
UC Davis researchers find molecule that targets brain tumors
Date:12/29/2008

(SACRAMENTO, Calif.) UC Davis Cancer Center researchers report today the discovery of a molecule that targets glioblastoma, a highly deadly form of cancer. The finding, which is published in the January 2009 issue of the European Journal of Nuclear Medicine and Molecular Imaging, provides hope for effectively treating an incurable cancer.

Glioblastoma is the most common and aggressive type of primary brain tumor in adults. It is marked by tumors with irregular shapes and poorly defined borders that rapidly invade neighboring tissues, making them difficult to remove surgically.

"These brain tumors are currently treated with surgery to remove as much of the tumor as possible followed by radiation to kill cancer cells left behind and systemic chemotherapy to prevent spread to nearby tissues," said Kit Lam, senior author of the study and UC Davis chief of hematology and oncology. "It is unfortunate that this approach does not extend survival significantly. Most patients survive less than one year."

To find new options for treating the disease, Lam and his colleagues began searching for a molecule that could be injected into a patient's bloodstream and deliver high concentrations of medication or radionuclides directly to brain tumor cells while sparing normal tissues. Through their study, they identified a molecule called LXY1 that binds with high specificity to a particular cell-surface protein called alpha-3 integrin, which is overexpressed on cancer cells.

They also tested the molecule's ability to target brain cancer by implanting human glioblastoma cells both beneath the skin and in the brains of mice. The researchers injected the mice with a radiolabeled version of LXY1 and, using near-infrared fluorescence imaging, showed that the molecule did preferentially bind to human glioblastoma cells in both locations.

"This outcome gives us great hope that we will be able to deliver targeted therapies to treat glioblastoma," said Lam.

Lam is planning to continue this work by repeating the experiments with powerful cancer treatments linked to the LXY1 molecule. They will begin with iodine-131, a form of radionuclide currently used to treat some cancers, as well as a nanoparticle, or "smart bomb," that would carry cancer-fighting drugs to diseased cells.


'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. UC Davis discovery offers hope for treating kidney cancer
2. UC Davis team refines cancer treatments to reduce potential nerve damage
3. UC Davis researchers exploring gene therapy to fight AIDS
4. UC Davis researchers discover Achilles heel in pancreatic cancer
5. UC Davis researchers discover a key to aggressive breast cancer
6. UC Davis chemical ecologist wins major award
7. UC Davis researchers discover new drug target for inflammatory disease
8. UC Davis researchers define characteristics, treatment options for XXYY syndrome
9. UC Davis researcher leads climate-change discovery
10. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
11. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... PUNE, India , March 28, 2017 ... (Analog, IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), ... Maintenance), Vertical, and Region - Global Forecast to 2022", ... 30.37 Billion in 2016 and is projected to reach ... 15.4% between 2017 and 2022. The base year considered ...
(Date:3/24/2017)... DUBLIN , Mar 24, 2017 Research ... Vehicle Access System Market Analysis & Trends - Industry Forecast to ... ... poised to grow at a CAGR of around 15.1% over the ... This industry report analyzes the market estimates and forecasts for ...
(Date:3/22/2017)... 21, 2017   Neurotechnology , a provider ... today announced the release of the SentiVeillance ... improved facial recognition using up to 10 surveillance, ... computer. The new version uses deep neural-network-based facial ... it utilizes a Graphing Processing Unit (GPU) for ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... WonderWorks, Myrtle Beach’s ... showcase the future of deep space exploration and inspire space enthusiasts. The exhibit ... and includes a guest appearance by former Shuttle Astronaut Don Thomas. , The ...
(Date:4/26/2017)... ... April 25, 2017 , ... LABS, Inc. (LABS) announced ... added to its extensive test menu: Nucleic Acid Testing (NAT) for ZIKV; and Enzyme ... only able to offer NAT screening for blood donors under an Investigational New Drug ...
(Date:4/26/2017)... ... April 26, 2017 , ... NextSteps 2017, NetDimensions’ annual global ... this May on the following dates: , ?    London, UK from May 10-11, ... Learning and Performance Institute will be the opening keynote speaker at the ...
(Date:4/26/2017)... , April 26, 2017  Genisphere LLC, ... platform, has signed a collaborative and sponsored research ... Silvia Muro . The overall goal of ... pharmacodynamics of various 3DNA designs and formulations after ... targeting diseases of the vasculature as well as ...
Breaking Biology Technology: