Navigation Links
UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
Date:8/24/2011

ntrol and Prevention estimates that 35 percent of American adults have metabolic syndrome, and its prevalence is increasing even in children and young adults globally. It doubles a person's chances of developing cardiovascular disease -- which can lead to heart attack or stroke -- and is at least five times the risk for developing diabetes.

"This is the plague of our time," said Jialal, who is also the editor-in-chief of the peer-reviewed journal Metabolic Syndrome and Related Disorders.

In the current study, biopsies were performed to remove subcutaneous adipose tissue, which accounts for about 80 percent of body fat, from the buttocks of 70 patients: 39 newly diagnosed with metabolic syndrome and 26 who were obese. Researchers also took standard measurements, such as fasting glucose and blood pressure, waist circumference and body mass index (BMI). Glucose measurements were used to estimate insulin resistance, and both waist size and BMI were used in the statistical analysis to match test subjects with their control counterparts.

Jialal and his collaborators then measured 11 biomarkers for diabetes and cardiovascular disease, as well as counting the number of macrophages in the fat tissue. These macrophages form crown-like structures around fat cells that have outgrown their blood supply and died. The presence of macrophages -- immune system cells that engulf and destroy cellular waste -- indicates the kind of inflammatory response implicated in cardiovascular disease.

Last year, Jialal published a study on these same 65 patients showing that they have both dysfunctional and fewer endothelial progenitor cells (EPCs) than control subjects. These cells eventually form the lining of blood vessels and are used as a measure of cardiovascular health. As in the current study, this abnormality cannot be explained simply by obesity. Jialal's team now is looking at differences in monocytes between the two study groups. The new data su
'/>"/>

Contact: Charles Casey
charles.casey@ucdmc.ucdavis.edu
916-734-9048
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis chemical ecologist wins major award
2. UC Davis researchers discover a key to aggressive breast cancer
3. UC Davis researchers discover Achilles heel in pancreatic cancer
4. UC Davis researchers exploring gene therapy to fight AIDS
5. UC Davis team refines cancer treatments to reduce potential nerve damage
6. UC Davis discovery offers hope for treating kidney cancer
7. UC Davis researchers find molecule that targets brain tumors
8. UC Davis research shows that newly discovered drug reduces heart enlargement
9. UC Davis bench-to-bedside research: Promising treatment in clinical trials
10. UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
11. UC Davis launches One Health care for wild mountain gorillas and human neighbors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... people lived on the land now called California, and ... availability of plants they used for food, fuel, tools, ... maintain desired habitat and natural resources. , Frank Lake, ... Station, will lead a field trip to ... Society of America,s 99th Annual Meeting, in Sacramento, Cal. ...
(Date:7/25/2014)... 2014)The link between autism and disrupted brain development ... the disease, and is largely unknown. However, thanks ... Initiative (SFARI), George Washington University (GW) researcher Anthony-Samuel ... integrative and in-depth answers to these key questions ... LaMantia, professor of pharmacology and physiology at the ...
(Date:7/25/2014)... engineering at the University of Houston, has written ... organ development., "Introduction to Tissue Engineering: Applications and ... the field of artificial organ development. Metin Akay, ... UH, served as a series editor on the ... published books on the subject of growing artificial ...
Breaking Biology News(10 mins):Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3GW researcher receives grant to answer the how and why of autism during development 2University of Houston researcher publishes textbook on tissue engineering 2
... cells called macrophages can destroy tumor cells by producing ... the environment inside the tumor somehow halts this production ... promote tumor growth. The new study ... switch. This protein normally stimulates protective inflammation. But in ...
... ability every aging Hollywood star would envy: they can ... the May 19 issue of the Journal of ... London, UK) and collogues have pinned down a protein ... that might help researchers understand why myelin production falters ...
... Fla. (May 19, 2008) The current issue of ... by researchers seeking new ways to treat Parkinsons disease ... and slowed physical movements related to insufficient levels of ... by using primate models to examine the potential therapy ...
Cached Biology News:Neural cell transplants may help those with Parkinson's disease 2Neural cell transplants may help those with Parkinson's disease 3
(Date:7/24/2014)... 2014  ECC West Africa, LLC (ECC) signed a ... University College Hospital (UCH) Ibadan Board of Management for ... design, construct, and operate and maintain a new, state-of-the-art ... Under the first of the 4-phase project, ECC will ... applications. UCH Ibadan intends to finance and develop the ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Cell Culture Market 2014-2018" report to their offering.  ... Cell culture is the in vitro growth of plant ... cell studies, and biopharmaceutical production. Cell culture is a ... culture instruments and cell culture consumables are necessary for ...
(Date:7/24/2014)... Calif. , July 24, 2014 SRI ... contract with the National Institute of Allergy and Infectious ... to conduct preclinical development of potential therapies for HIV ... drugs to treat HIV and AIDS and the complications ... as microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... RADI Medical Systems today,announced improvements to their ... which will begin shipments immediately., (Photo: ... generation of the PressureWire(R) Certus features a ... key,advantages for physicians. The new large entry ...
... /Xinhua-PRNewswire-FirstCall/ -- China-Biotics,Inc. (OTC Bulletin Board: CHBT) ... in the manufacture, research, development,marketing and distribution ... China-Biotics, Chief Technology Officer, has been invited ... Annual Food Safety Technology Forum,2008 (the "Forum")., ...
... Milestones and Maintain ... Commitment to Strategy, ... Inc.,(TSX: MGI, OTC: MGIFF), a clinical-stage developer of drugs for ... shareholders,for the purpose of acquiring control of MIGENIX,s board of ...
Cached Biology Technology:RADI Medical Systems Launches Next Generation PressureWire(R) Certus 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 2China-Biotics, Inc. to Present at China's 3rd Annual Food Safety Technology Forum 2008 3MIGENIX Corporate Update and Requisition of Special Meeting 2MIGENIX Corporate Update and Requisition of Special Meeting 3MIGENIX Corporate Update and Requisition of Special Meeting 4MIGENIX Corporate Update and Requisition of Special Meeting 5MIGENIX Corporate Update and Requisition of Special Meeting 6MIGENIX Corporate Update and Requisition of Special Meeting 7MIGENIX Corporate Update and Requisition of Special Meeting 8
... Todays research and biologic production demands ... guesswork to confirming viable cell populations. Therefore, ... cells must be determined accurately and precisely. ... an automatic and cost effective means to ...
... SureLINK Bioconjugation Kit provides a powerful yet ... and nuceleic acids. The kit provides the ... reagents for quantifying conjugation efficiencies. It enables ... biotin and other tags with a variety ...
... the sensitivity and versatility you expect from ... counting with selected photomultipliers ensure superior sensitivity ... with up to 2 reagent injectors the ... assays as well as other luminescence applications ...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
Biology Products: