Navigation Links
UC Davis researchers exploring gene therapy to fight AIDS
Date:12/5/2008

these cells and bringing on full-blown AIDS.

What researchers discovered is that there is a natural mutation in less than 1 percent of Caucasians that results in a lack of CCR5 receptors on any of their cells.

"We also found that these people are naturally resistant to HIV," said Bauer. "So, more than 10 years ago, we began our work creating a gene that would knock down expression of CCR5 and other key receptors and interfere with other routes of HIV infection."

For IPS-based anti-HIV gene therapy to become reality, UC Davis researchers must first conduct safety and efficacy trials. Researchers have created a mouse model that replicates a normally functioning human immune system.

"We can now move forward and test the safety of the viral vectors, as well as the ability of anti-HIV genes to inhibit HIV infection," noted Anderson. "The humanized mouse model is an important step toward bringing this possible cure to patients."

Bauer and Anderson are hoping to demonstrate in their mouse model that HIV-infection cannot occur following their gene therapy treatment, providing the needed confidence in safety before embarking on clinical trials. This work and studies on the clinical use of IPS cells, Bauer predicts, will lead to a cure for AIDS.

"A real cure will come when we can replace all the hematopoietic stem cells with HIV resistant stem cells. What is so exciting is that we're clearly on the path of doing just that," said Bauer.


'/>"/>

Contact: Charles Casey
charles.casey@ucdmc.ucdavis.edu
916-734-9048
University of California - Davis - Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis bird-flu expert calls for changes in early-warning system
2. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
3. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
4. UC Davis researcher leads climate-change discovery
5. UC Davis researchers define characteristics, treatment options for XXYY syndrome
6. UC Davis researchers discover new drug target for inflammatory disease
7. UC Davis chemical ecologist wins major award
8. UC Davis researchers discover a key to aggressive breast cancer
9. UC Davis researchers discover Achilles heel in pancreatic cancer
10. Researchers identify proteins involved in new neurodegenerative syndrome
11. Texas researchers and educators head for Antarctica
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/9/2015)... SAN JOSE, Calif. , April 9, 2015 /PRNewswire/ ... of human interface solutions, announced today that it will ... 2015 on Thursday, April 23, 2015, after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
(Date:4/2/2015)... Sweden , April 2, 2015 ... for Q1 2015 attributed to somewhat higher than 125 ... in the year-end report 2014 that revenues for Q1 ... that the company reported for Q4 2014. The operating ... to be negative. The complete interim report will as ...
(Date:3/31/2015)... , March 31, 2015   Guidepoint , a ... of the Post-Surgical Pain Management TRACKER, part of the ... usage trends in the medical device and therapeutics markets. ... data including treatment volumes, market share, and adoption rates ... associated with joint surgery. The Post-Surgical Pain ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2Fingerprint Cards Revises Revenues for Q1 2015 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3
... today called for Europe to invest more funds into the ... crucial role in the function of human cells and which ... diabetes to Alzheimer,s. Common lipids such as cholesterol are ... of cells and tissues, but human cells contain thousands of ...
... got a shot of youthful vigor in a stem cell ... the path for research on new treatments for age-related degenerative ... In a new study to be published June 15 ... , researchers identified two key regulatory pathways that control how ...
... on June 13, 2008, Singapore scientists at the ... of Singapore (NUS) unveil an atlas that showing the ... factors) that are critical for maintaining the embryonic stem ... sequencing technology, the scientists discovered over 3,000 hotspots. These ...
Cached Biology News:Europe-wide investment in lipid research will help tackle disease, says new report 2Stem cell researchers give old muscle new pep 2Stem cell researchers give old muscle new pep 3Stem cell researchers give old muscle new pep 4Wealth of genomic hotspots discovered in embryonic stem cells 2
(Date:5/5/2015)... 2015 Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens,  today announced that ... America Merrill Lynch 2015 Health Care Conference on May 12 ... at the Wynn, Las Vegas NV. ... be available through the investor relations section of Roka Bioscience,s ...
(Date:5/5/2015)... Plymouth, Mich. (PRWEB) May 05, 2015 ... expanding publishing services to develop custom course materials for ... with annual enrollments as low as 200 students. ... to a broader range of higher education instructors,” said ... around the country, we can do our part to ...
(Date:5/5/2015)... 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today ... trading on OTCQB  Marketplace, the market for developmental ... for a continuous public market for trading shares ... quotes and market information on us through ... includes U.S. and international companies in venture stage, ...
(Date:5/5/2015)... 5, 2015 Reprints Desk, Inc., a Research ... access to scientific, technical and medical (STM) content, today ... Association of Southeastern Research Libraries (ASERL) . ... across 11 southeastern states. Founded in 1956, ASERL has ... to address the continually changing needs of its member ...
Breaking Biology Technology:Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2Tikcro Technologies Announces Approval to Continue Trading on OTCQB 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 2Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 3Association of Southeastern Research Libraries Partners with Reprints Desk to Improve Access for Hard-to-Find Materials 4
... April 5, 2011 Embryo Donation International ... facilities in the United States, officially opened today to ... globe desiring to build a family.     ... mission is to reduce the number of frozen ...
... YORK, April 5, 2011 Reportlinker.com announces that ... its catalogue: DNA Sequencing - ... http://www.reportlinker.com/p0203540/DNA-Sequencing---technologiesmarkets-and-companies.html This report briefly ... sequencing technologies, and their applications. Current large and ...
... PITTSBURGH, April 5, 2011 Mylan Inc. (Nasdaq: ... subsidiary Bioniche Pharma has launched Octreotide Acetate Injection ... Novartis, Sandostatin®, a treatment for a rare hormonal ... used to suppress or inhibit severe diarrhea associated ...
Cached Biology Technology:A New Company Is Born - Embryo Donation International 2Reportlinker Adds DNA Sequencing - Technologies, Markets and Companies 2Mylan Launches Generic Version of Sandostatin® 2
... Alkaline Phosphatase Conjugation ... Fluorescein Isothiocyanate Conjugation R. Phycoerythrin Conjugation ... Alexa Fluor 488 Conjugation Alexa Fluor ... Rpe-Alexa Fluor 750 Conjugation Apc-Alexa ...
Qa-1 (6A8.6F10)...
Human Cell Line Slides...
Anti-human VEGFR-1/Flt-1, clone Flt-1/EWI, Monoclonal Antibody...
Biology Products: