Navigation Links
UC Davis researchers discover how HIV turns food-poisoning into lethal infection
Date:3/24/2008

(SACRAMENTO, Calif.) Nearly half of all HIV-positive African adults who become infected with Salmonella die from what otherwise would be a seven-day bout of diarrhea. Now, UC Davis School of Medicine scientists have discovered how salmonella becomes lethal for AIDS patients. Their findings also implicate a mechanism by which HIV evades the powerful drugs used to treat AIDS.

We have found the defect in the immune response that allows Salmonella to cross the mucosal barrier of the gut, enter the bloodstream and infect other organs, said Andreas Bumler, a UC Davis professor of medical microbiology and immunology and co-author of the study.

The results of the study, which will be published online by Nature Medicine March 23, revealed that viral infection of the intestine results in the depletion of a type of white blood cell, called Th-17, in the gut mucosa. This T helper lymphocyte produces IL-17, a cytokine or chemical messenger that plays a crucial role in the inflammatory response, recruiting other immune system cells to the site of infection.

This kind of interruption in the guts immune response could be allowing HIV to maintain reservoirs that evade drug treatments, said Satya Dandekar, professor and chair of the department of medical microbiology and immunology.

Its like putting out the fire, but leaving the embers smoldering, Dandekar said.

The rise in patients with acquired immune deficiency syndrome (AIDS) in sub-Saharan Africa has led to a dramatic increase in the frequency of non-typhoidal Salmonella serotypes (NTS), the strains of the bacteria that cause acute food-borne disease world wide. Normally, this infection is limited to the intestine, causing gastroenteritis. In AIDS patients, however, the infection spreads to the bloodstream and causes what is called NTS bacteremia.

While at a conference, Bumler was surprised to learn from epidemiologist and physician Melita Gordon of the University o
'/>"/>

Contact: David Ong
david.ong@ucdmc.ucdavis.edu
916-734-9049
University of California - Davis - Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis bird-flu expert calls for changes in early-warning system
2. Yerkes researchers identify language feature unique to human brain
3. Stanford researchers developing 3-D camera with 12,616 lenses
4. 19 researchers selected as 2008 Leopold Leadership Fellows
5. Researchers discover how stealthy HIV protein gets into cells
6. Researchers at Stockholm University awarded the Descartes prize
7. Wisconsin researchers describe how digits grow
8. Antarcticas coldest, darkest season draws Montana State University researchers
9. Researchers discover the structural alphabet of RNA
10. Carnegie Mellon researchers create invisibiity cloak
11. Researchers visualize complex pigment mixtures in living cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... hungry diner ripping open a dinner roll, a fuel ... open a hydrogen molecule. Now researchers have captured a ... halves of its hydrogen feast. The view confirms previous ... catalyst work better for alternative energy uses. , This ... where the hydrogen halves end up in the structure ...
(Date:4/23/2014)... a unique rhythmic sound, recorded for decades in the ... minke whale ( Balaenoptera bonaerensis ). First described and ... it sounded like a duck, the bio-duck sound has ... but its source has remained a mystery, until now. ... deployed acoustic tags on two Antarctic minke whales in ...
(Date:4/23/2014)... in Buenos Aires yesterday, Argentina joins the European ... state. The move strengthens the ties between the ... grants Argentinian scientists access to EMBL,s world-class facilities ... "Ever since its inception, fostering excellent life science ... the core of EMBL,s mission," says EMBL Director ...
Breaking Biology News(10 mins):Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3
... of mold and other causes of Sick Building ... with The American Phytopathological Society (APS). , Sick ... which building occupants experience health problems while inside ... with SBS range from allergy attacks and asthma ...
... and taking in nutrients, plant roots secrete a ... roots, as well as insects and microbes. But ... has not been extensively investigated—until now. Using the ... cabbage, Jorge Vivanco and co-workers at Colorado State ...
... earliest cities in northern China starting as far back ... successful rice farming combined with other crops, says University ... associate rice with Chinese agriculture, most archeologists have, until ... most important food associated with northern China. However, recent ...
Cached Biology News:What's really making you sick? Plant pathologists offer the science behind Sick Building Syndrome 2Roots Engage in Underground Chemical Warfare 2
(Date:1/15/2014)... January 15, 2014 Cynvenio, a cancer ... through the genomic analysis of tumor cells in the ... a web-based cancer decision support application powered by CollabRx, ... Cynvenio’s ClearID™ genomic test, Therapy Finder will provide breast ...
(Date:1/15/2014)... This webinar will focus on EMA and ... in biosimilars. , Regulatory frameworks are evolving many countries ... the complex nature of biopharmaceuticals makes the demonstration of ... challenging. Based on the specific aspects of biosimilar drug ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Two champions ... continued their sponsorship of an annual competition for middle ... and access to, innovative STEM study. The competition presents ... TEAMS: Tests of Engineering Aptitude, Mathematics, and Sciences ...
(Date:1/15/2014)... 15, 2014 2013 was a banner ... State Technologies®. They saw continued independent research led by ... were awarded a $1 million grant from the Susanne ... and Behavior” a peer reviewed journal, Amy Grant highlighted ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Nov. 12 AvidBiotics Corp. announced the issuance ... for generating massive diversity within precisely targeted sites ... is referred to as Diversity Generating Retroelements (DGR) ... States (#7,585,957) and in Europe (#1,173,995). UCLA ...
... Nov. 12 /PRNewswire-FirstCall/ - BioMS Medical Corp. (TSX: MS) ... and nine months ended September 30, 2009. , During ... BioMS Medical and Eli Lilly and Company (NYSE: LLY) ... commercial rights to dirucotide are returned to BioMS. , ...
... 12 Regado Biosciences, a privately held company leading ... announced that David Mazzo, PhD, CEO and President, will ... Healthcare Conference at the St. Regis Hotel in New ... 1:10pm (EST) on Tuesday, November 17 and will include ...
Cached Biology Technology:AvidBiotics Corp. Granted Key U.S. and European Patents on Unique Protein Modification Platform 2BioMS Medical Announces Third Quarter 2009 Results 2BioMS Medical Announces Third Quarter 2009 Results 3BioMS Medical Announces Third Quarter 2009 Results 4BioMS Medical Announces Third Quarter 2009 Results 5BioMS Medical Announces Third Quarter 2009 Results 6BioMS Medical Announces Third Quarter 2009 Results 7BioMS Medical Announces Third Quarter 2009 Results 8Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2
... ml Dynabeads Mouse pan B (B220), ... antibody. For the efficient positive isolation ... directly from spleen or lymph node ... on mouse B cells and lytically ...
POU domain, class 2, transcription factor 2,...
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
1, 2 or 8 PreMixes are included as part of the FailSafe™ PCR System....
Biology Products: