Navigation Links
UC Davis researchers discover complexities of DNA repair
Date:10/23/2011

57) that favors recombination repair and another (Srs2) that inhibits recombination repair. By controlling the balance between the two enzymes, Rad51 can initiate genetic repair - or the u-turn - as needed.

"It is a tug-of-war that has important implications for the cell because, if recombination occurs at the wrong time in the wrong place, the cell may die as a consequence." The ability of the repair system to abort ill-fated repair attempts, gives the cell a second shot, improving cellular survival after its DNA is damaged. This is exactly what is dreaded in cancer treatment.

"There are a lot of hints in the scientific literature suggesting that DNA repair contributes to resistance to treatments that are based on inducing DNA damage such as radiation or certain types of chemotherapy," Heyer said. "The ability of cancer cells to withstand DNA damage directly affects treatment outcome, and understanding the fundamental mechanisms of the DNA repair systems will enable new approaches to overcome treatment resistance."

Heyer said the team's next step is to look at the enzyme system in humans and see whether they find the same principles at work. This work has received funding and has already begun. One application of this work will be to target the self-correcting mechanism in cancer cells as a way of sensitizing them to radiation and/or chemotherapy treatments.

"If we can confirm that these types of mechanisms exist in human cells, then we will have an approach for making cancer cells more sensitive to DNA damage-inducing treatments."


'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis neurosurgeons use adult stem cells to grow neck vertebrae
2. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
3. 2 UC Davis plant biologists named as HHMI-GBMF investigators
4. NCI partners with Jackson Laboratory, UC Davis to speed cancer clinical trials
5. AAAS news briefs from UC Davis
6. UC Davis energy experts to help US Navy get greener
7. Death in the bat caves: UC Davis experts call for action against fast-moving disease
8. UC Davis study shows plants moved downhill, not up, in warming world
9. UC Davis study: Wild salmon decline was not caused by sea lice from farm salmon
10. UC Davis study links obesity with lowest earnings
11. At UC Davis, South Americans learn to help health, environment and industry back home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... 25, 2015  ABC Financial Services (ABC), the ... Health and Fitness Industry, today announced enhancements to ... The latest upgrade includes advances to the agreement ... check-in via Identity One fingerprint biometrics. The features ... interactive displays at the International Health, Racquet & ...
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris Biometrics in ... US, Canada , Japan ... , Middle East , and ... for the period 2013 through 2020. Also, a seven-year historic ... are derived from primary and secondary research. Company profiles are ...
(Date:2/24/2015)... 24, 2015 This report analyzes the worldwide markets for ... Face Biometrics, and Voice Biometrics. The report provides separate comprehensive analytics ... , Europe , Asia-Pacific ... , and Latin America . Annual estimates ... a seven-year historic analysis is provided for these markets. Market data ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16
... Institute (HBI) at the University of Calgary,s Faculty of ... food drive in rats. This new discovery, published online ... insight into why stress is thought to be one ... brain produces neurotransmitters (chemicals responsible for how cells communicate ...
... found that environmental factors have changed the distribution patterns ... species found in waters from Cape Hatteras to Newfoundland, ... mackerel migrate great distances on a seasonal basis to ... water temperature. These findings could have significant implications for ...
... Kingdom of Saudi Arabia have identified a mutation on ... amyotrophic lateral sclerosis (ALS). Study findings published today in ... American Neurological Association and the Child Neurology Society, show ... in motor neuron function and disease development. ...
Cached Biology News:Scientists highlight link between stress and appetite 2Scientists link shifting Atlantic mackerel distribution to environmental factors, changing climate 2Scientists link shifting Atlantic mackerel distribution to environmental factors, changing climate 3Scientists identify mutation in SIGMAR1 gene linked to juvenile ALS 2
(Date:2/27/2015)... Calif. , Feb. 27, 2015  Steep Hill, ... the US and internationally, intends to open a full ... Albuquerque, New Mexico , bringing advanced scientific tools ... cannabis. Steep Hill is currently the only ... to conduct potency and contaminant testing in order to ...
(Date:2/26/2015)... Feb. 26, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" ... sciences company that develops and commercializes proprietary technologies and ... and operational results for the fiscal first quarter ended ... are in Canadian dollars (CAD), unless otherwise stated. ... win new business from our existing customers and add ...
(Date:2/26/2015)... 26, 2015 The Movement for Indefinite ... support life extension technologies and awareness. The event is ... Time, on March 21st 2015, in a live Google ... Eric Schulke, Founder of MILE, says, “Our lives are ... The Movement for Indefinite Life Extension is raising awareness ...
(Date:2/26/2015)... PA (PRWEB) February 26, 2015 ... 9 -12, at the Ernest N. Morial Convention ... exhibitors (count as of February 19, 2015) displaying ... in industrial, academic, and government labs. The Exposition ... as, but not limited to, analytical chemistry; drug ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2SQI Diagnostics Reports First Quarter Financial Results 2SQI Diagnostics Reports First Quarter Financial Results 3SQI Diagnostics Reports First Quarter Financial Results 4SQI Diagnostics Reports First Quarter Financial Results 5SQI Diagnostics Reports First Quarter Financial Results 6Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3Pittcon 2015 Announces Exposition Highlights 2
... 17, 2010 ... if (typeof(lpUnit)==,undefined,) var ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s ... one. for (var r in data.results) { first_result = data.results[r]; break; } for (var key in first_result) ...
... DIEGO, Aug. 17 Imagenetix, Inc. (OTC Bulletin Board: ... 30, 2010. Net sales decreased 36% for the first quarter of ... of last year.   Net loss for the first quarter was ... or $.04 per share for the same period of the prior ...
... announced today that it has initiated a phase 2 ... the treatment of PHN. XEN402 has ... and recently concluded a 21-day cumulative dose safety tolerability ... was well tolerated and achieved good drug concentrations in ...
Cached Biology Technology:Shire plc - Statement re ProAmatine 2Shire plc - Statement re ProAmatine 3Shire plc - Statement re ProAmatine 4Shire plc - Statement re ProAmatine 5Shire plc - Statement re ProAmatine 6Imagenetix, Inc. Reports First Quarter 2011 Results 2Imagenetix, Inc. Reports First Quarter 2011 Results 3Xenon Pharmaceuticals Initiates a Phase 2 Clinical Trial in Post Herpetic Neuralgia (PHN) for Topical XEN402. 2
Mouse monoclonal antibody raised against a partial recombinant FAAH. NCBI Entrez Gene ID = FAAH...
Mouse polyclonal antibody raised against a partial recombinant CSRP3. NCBI Entrez Gene ID = 8048...
...
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
Biology Products: