Navigation Links
UC Davis researchers discover complexities of DNA repair
Date:10/23/2011

(SACRAMENTO, Calif.) An international team of scientists led by UC Davis researchers has discovered that DNA repair in cancer cells is not a one-way street as previously believed. Their findings show instead that recombination, an important DNA repair process, has a self-correcting mechanism that allows DNA to make a virtual u-turn and start over.

The study's findings, which appear in the Oct. 23 online issue of the journal Nature, not only contribute new understanding to the field of basic cancer biology, but also have important implications for potentially improving the efficacy of cancer treatments.

"What we discovered is that the DNA repair pathway called recombination is able to reverse itself," said Wolf-Dietrich Heyer, UC Davis professor of microbiology and of molecular and cellular biology and co-leader of Molecular Oncology at UC Davis Cancer Center. "That makes it a very robust process, allowing cancer cells to deal with DNA damage in many different ways. This repair mechanism may have something to do with why some cancer cells become resistant to radiation and chemotherapy treatments that work by inducing DNA damage."

Heyer likens this self-correcting ability of the DNA repair system to driving in a modern city where u-turns and two-way streets make it easy to rectify a wrong turn. "How much harder would it be to re-trace your path if you were in a medieval Italian city with only one-way streets," he said.

In the current study, Heyer and his colleagues used yeast as a model system to elucidate the mechanisms of DNA repair. They expect their findings, like most that come out of work on yeast, will be confirmed in humans. "Whether in yeast or humans, the pathways that repair DNA are the same," Heyer said.

The research team used electron microscopy to observe repair proteins in action on strands of DNA. They saw a presynaptic filament called Rad51 regulating the balance between one enzyme (Rad55-Rad
'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC Davis neurosurgeons use adult stem cells to grow neck vertebrae
2. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
3. 2 UC Davis plant biologists named as HHMI-GBMF investigators
4. NCI partners with Jackson Laboratory, UC Davis to speed cancer clinical trials
5. AAAS news briefs from UC Davis
6. UC Davis energy experts to help US Navy get greener
7. Death in the bat caves: UC Davis experts call for action against fast-moving disease
8. UC Davis study shows plants moved downhill, not up, in warming world
9. UC Davis study: Wild salmon decline was not caused by sea lice from farm salmon
10. UC Davis study links obesity with lowest earnings
11. At UC Davis, South Americans learn to help health, environment and industry back home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... A new modeling study suggests that fish consumption ... infant exposure to long-lived contaminants like persistent organic ... a team of researchers including University of Toronto ... Wania, looks at how different levels of environmental ... behavior of chemicals in the body influenced exposure ...
(Date:4/17/2014)... KAN. A Kansas State University engineer has ... and remotely detects improvised explosive devices. The same ... William Dunn, the Steven M. and Kay L. ... mechanical and nuclear engineering, and his research team ... hidden underground or in car trunks. The distance ...
(Date:4/17/2014)... Several parasites and pathogens that devastate honeybees in Europe, ... Africa, but do not appear to be impacting native ... team of researchers., The invasive pests include including ... East African honeybees appear to be resilient to these ... used to control pests in Europe, Asia and the ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... the controversial method of mining shale gas, is widespread across ... New research in the Annals of the New York ... including pollution from toxic chemicals, the building of well pads ... engendered a great deal of controversy, largely because of its ...
... in India reduce rates of syphilis, HIV and other sexually ... About two million Indians are infected with ... Maharashtra and Tamil Nadu. The study, led by Professor Prabhat ... Health and St. Michael,s Hospital,s Centre for Global Health Research ...
... use to group together and move around the body called ... by scientists at UCL. Published in Nature Cell ... when cancer cells interact with healthy cells in order to migrate ... healthy cells and use them to travel long distances, but how ...
Cached Biology News:HIV prevention among female sex workers in India reduces HIV and syphilis 2'Chase and run' cell movement mechanism explains process of metastasis 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... 14, 2014 EquitiesIQ, a leading informational ... ALQA). Alliqua is an emerging biomedical company acquiring, developing, ... care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... seasoned management team and Board, which launched the company’s ...
(Date:1/14/2014)... Mass. , Jan. 14, 2014  RXi Pharmaceuticals ... discovering, developing and commercializing innovative therapies addressing major ... that it received the Notice of Allowance from ... its unique self-delivering RNAi compounds (sd-rxRNA®), for the ...
(Date:1/14/2014)... 14, 2014 During the 1600’s through the ... “The Doctor’s Plague.” In this time period, doctors did not ... at times, to the death of vulnerable patients. In the ... that they may be unwittingly transmitting herpes viruses to their ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... Oramed Pharmaceuticals Inc. (OTCBB: ORMP.OB) ( http://www.oramed.com ... today that its work entitled "Evaluation of the Safety ... Volunteers" will be presented at the Eleventh Annual Meeting ... San Francisco, California. "The selection of Oramed ...
... 25, 2011 Reportlinker.com announces that a ... its catalogue: Global Automated ... http://www.reportlinker.com/p092467/Global-Automated-And-Rapid-Microbiological-Tests-Industry.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=In_Vitro_Diagnostic This ... and Rapid Microbiological Tests in US$ Million ...
... some patients develop a potentially deadly blood infection from ... bodies have gene mutations that allow them to stick ... infections because of a biofilm of persistent bacterial bugs ... some strains of the bacteria, Staphylococcus aureus, have just ...
Cached Biology Technology:Oramed Pharmaceuticals Chosen to Present at the Diabetes Technology Meeting (October 27-29, 2011; San Francisco, CA) 2Global Automated And Rapid Microbiological Tests Industry 2Global Automated And Rapid Microbiological Tests Industry 3Global Automated And Rapid Microbiological Tests Industry 4Global Automated And Rapid Microbiological Tests Industry 5Global Automated And Rapid Microbiological Tests Industry 6Global Automated And Rapid Microbiological Tests Industry 7Global Automated And Rapid Microbiological Tests Industry 8Global Automated And Rapid Microbiological Tests Industry 9Global Automated And Rapid Microbiological Tests Industry 10Global Automated And Rapid Microbiological Tests Industry 11Global Automated And Rapid Microbiological Tests Industry 12Global Automated And Rapid Microbiological Tests Industry 13Global Automated And Rapid Microbiological Tests Industry 14Global Automated And Rapid Microbiological Tests Industry 15Global Automated And Rapid Microbiological Tests Industry 16Global Automated And Rapid Microbiological Tests Industry 17Global Automated And Rapid Microbiological Tests Industry 18Global Automated And Rapid Microbiological Tests Industry 19Global Automated And Rapid Microbiological Tests Industry 20Global Automated And Rapid Microbiological Tests Industry 21Global Automated And Rapid Microbiological Tests Industry 22Global Automated And Rapid Microbiological Tests Industry 23Global Automated And Rapid Microbiological Tests Industry 24Global Automated And Rapid Microbiological Tests Industry 25Global Automated And Rapid Microbiological Tests Industry 26Study offers clues as to why some patients get infections from cardiac implants 2Study offers clues as to why some patients get infections from cardiac implants 3Study offers clues as to why some patients get infections from cardiac implants 4Study offers clues as to why some patients get infections from cardiac implants 5