Navigation Links
UC Davis researchers discover a biological link between diabetes and heart disease
Date:9/30/2013

(SACRAMENTO, Calif.) -- UC Davis Health System researchers have identified for the first time a biological pathway that is activated when blood sugar levels are abnormally high and causes irregular heartbeats, a condition known as cardiac arrhythmia that is linked with heart failure and sudden cardiac death.

Reported online today in the journal "Nature," the discovery helps explain why diabetes is a significant independent risk factor for heart disease.

"The novel molecular understanding we have uncovered paves the way for new therapeutic strategies that protect the heart health of patients with diabetes," said Donald Bers, chair of the UC Davis Department of Pharmacology and senior author of the study.

While heart disease is common in the general population, the risk is up to four times greater for diabetics, according to the National Institutes of Health. The American Heart Association estimates that at least 65 percent of people with diabetes die from heart disease or stroke and has emphasized the need for research focused on understanding this relationship.

Through a series of experiments, Bers, his UC Davis team and their collaborators at the Johns Hopkins University School of Medicine showed that the moderate to high blood glucose levels characteristic of diabetes caused a sugar molecule (O-linked N-acetylglucosamine, or O-GlcNAc) in heart muscle cells to fuse to a specific site on a protein known as calcium/calmodulin-dependent protein kinase II, or CaMKII.

CaMKII has important roles in regulating normal calcium levels, electrical activity and pumping action of the heart, according to Bers. Its fusion with O-GlcNAc, however, led to chronic overactivation of CaMKII and pathological changes in the finely tuned calcium signaling system it controls, triggering full-blown arrhythmias in just a few minutes. The arrhythmias were prevented by inhibiting CaMKII or its union with O-GlcNAc.

"While s
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
2. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
3. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
4. UC Davis researchers aid effort to sequence the complex wheat genome
5. UC Davis study deflates notion that pear-shaped bodies more healthy than apples
6. UC Davis researchers discover molecular target for the bacterial infection brucellosis
7. UC Davis team spikes stem cells to generate myelin
8. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
9. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
10. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
11. UNH researchers find African farmers need better climate change data to improve farming practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
(Date:10/15/2014)... Rosenstiel Award for Distinguished Work in Biomedical Science by ... of genomic instability and its implications for the immune ... to win the Rosenstiel Award; the first, Rod McKinnon, ... the Charles A. Janeway Professor of Pediatrics and Professor ... at the Howard Hughes Medical Institute at Boston Children,s ...
(Date:10/14/2014)... discriminating thieves, prostate cancer tumors scavenge and hoard copper ... such avarice may be a fatal weakness. , ... kill prostate cancer cells by delivering a trove of ... diseased cells brimming with the mineral, leaving non-cancer cells ... already commercially available for other uses, could soon be ...
Breaking Biology News(10 mins):Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Prostate cancer's penchant for copper may be a fatal flaw 2
... issues, 100 percent fruit and vegetable juices do help reduce ... conclusion is the result of a European study designed to ... significant role in reducing risk for both cancer and cardiovascular ... are comparable in their ability to reduce risk compared to ...
... created from poultry feathers may add value to ... environmental problem of plastic waste. , According to ... million tons of non-biodegradable plastic waste ends up ... of biological systems engineering at Virginia Tech, is ...
... to process information more chaotically than has long been ... by scientists at the University of Bonn. The passing ... they show, occur exclusively at the synapses, i.e. the ... that the neurons release their chemical messengers along the ...
Cached Biology News:100 percent juices found as beneficial to health as fruits and vegetables 2Researcher examines polymers created with poultry feathers 2Brain works more chaotically than previously thought 2Brain works more chaotically than previously thought 3
(Date:10/17/2014)... received a $451,781 Air Force Office of Scientific Research ... and nano-scale level that will provide clues for predicting ... and Aerospace Engineering, said the new technology and process ... of an aircraft,s wing., "We,ll be able to determine ... at it on this scale," Huang said. "Certain patterns ...
(Date:10/17/2014)... SAN DIEGO and HILDEN, ...   , Translational research ... new capabilities being presented at the American Society ... Volume of 250,000-plus DNA samples linked to Ingenuity ... superior depth for genomic analysis  Ingenuity ...
(Date:10/17/2014)... October 17, 2014 Bioquell, provider ... upon by health facilities around the world to ... being treated. Among the many places the hydrogen ... Health Presbyterian Hospital Dallas and at the National ... vapor-producing robots have been utilized to decontaminate patient ...
(Date:10/17/2014)... 17, 2014 The global SWIR market ... analysis and forecast of revenue. This market is valued ... reach $97.9 million by 2019, at a CAGR of ... TOC of the global SWIR market report, to get ... provides a glimpse of the segmentation of the market, ...
Breaking Biology Technology:UT Arlington project to detect possible damages in aircraft parts early in process 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 2QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 3QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 4QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 5QIAGEN Demonstrates Expanded Bioinformatics Workflows at ASHG; Strong Market Adoption as Researchers Analyze Genomic Data on More Than a Quarter-Million Samples in Secure Private Cloud 6Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 2The global SWIR market is expected to reach $97.9 million by 2019 - New Report by MicroMarket Monitor 3
... Therapeutics Corporation today,announced that Blake M. Paterson M.D., ... in Bioscience Award from the Greater Baltimore Council.,Dr. ... nominees,submitted by businesses, bioscience advocates, higher education,institutions and ... Dr. Paterson has received this award from the ...
... March 18 Caliper Life,Sciences, Inc. (Nasdaq: ... the,Lehman Brothers Global Healthcare Conference in Miami, will ... EDT. Kevin Hrusovsky, President and CEO of,Caliper, will ... The live,webcast can be accessed at, http://cc.talkpoint.com/LEHM002/031808a_jw/default.asp?entity=Caliper . ...
... Three biotech CEOs and,the president of one ... by the Greater Baltimore Committee as winners of ... the 2008 Greater Baltimore Region Bioscience Awards are:, ... E. Askew, President & CEO, CSA,Medical, Inc. Askew,s ...
Cached Biology Technology:Blake M. Paterson MD, CEO and Co-founder of Alba Therapeutics, Wins Greater Baltimore Committee 2008 Leadership in Bioscience Award 2Three CEOs and University President Named Winners of Greater Baltimore Committee's 2008 Baltimore Region Bioscience Awards 2