Navigation Links
UC Davis researchers discover a biological link between diabetes and heart disease
Date:9/30/2013

(SACRAMENTO, Calif.) -- UC Davis Health System researchers have identified for the first time a biological pathway that is activated when blood sugar levels are abnormally high and causes irregular heartbeats, a condition known as cardiac arrhythmia that is linked with heart failure and sudden cardiac death.

Reported online today in the journal "Nature," the discovery helps explain why diabetes is a significant independent risk factor for heart disease.

"The novel molecular understanding we have uncovered paves the way for new therapeutic strategies that protect the heart health of patients with diabetes," said Donald Bers, chair of the UC Davis Department of Pharmacology and senior author of the study.

While heart disease is common in the general population, the risk is up to four times greater for diabetics, according to the National Institutes of Health. The American Heart Association estimates that at least 65 percent of people with diabetes die from heart disease or stroke and has emphasized the need for research focused on understanding this relationship.

Through a series of experiments, Bers, his UC Davis team and their collaborators at the Johns Hopkins University School of Medicine showed that the moderate to high blood glucose levels characteristic of diabetes caused a sugar molecule (O-linked N-acetylglucosamine, or O-GlcNAc) in heart muscle cells to fuse to a specific site on a protein known as calcium/calmodulin-dependent protein kinase II, or CaMKII.

CaMKII has important roles in regulating normal calcium levels, electrical activity and pumping action of the heart, according to Bers. Its fusion with O-GlcNAc, however, led to chronic overactivation of CaMKII and pathological changes in the finely tuned calcium signaling system it controls, triggering full-blown arrhythmias in just a few minutes. The arrhythmias were prevented by inhibiting CaMKII or its union with O-GlcNAc.

"While s
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
2. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
3. UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
4. UC Davis researchers aid effort to sequence the complex wheat genome
5. UC Davis study deflates notion that pear-shaped bodies more healthy than apples
6. UC Davis researchers discover molecular target for the bacterial infection brucellosis
7. UC Davis team spikes stem cells to generate myelin
8. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
9. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
10. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
11. UNH researchers find African farmers need better climate change data to improve farming practices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... ) -- Scientists at the Houston Methodist Research Institute ... single cells using a pipette -- a common laboratory ... feat and preliminary test results in a recent issue ... . , "Studying single cells and their unique functions ... nanomedicine department. faculty member Lidong Qin, Ph.D., the project,s ...
(Date:8/19/2014)... and other science courses are increasingly being asked ... they have a new textbook to help them ... this month by Princeton Press and co-authored by ... Biological Synthesis (NIMBioS), teaches readers about basic mathematical ... explore and explain biological phenomena. , Suitable for ...
(Date:8/19/2014)... Anyone who has ever had a glass of fizzy ... the air. But in a finding with wide industrial ... push some particles down into the liquid as well. ... aerosol droplets, so we were surprised, and fascinated, to ... the same process injected tiny oil droplets into the ...
Breaking Biology News(10 mins):Moving single cells around -- accurately and cheaply 2New textbook introduces undergraduates to mathematics for the life sciences 2Bubbling down: Discovery suggests surprising uses for common bubbles 2Bubbling down: Discovery suggests surprising uses for common bubbles 3
... ( Lepilemur sahamalazensis ), other than the fact it roosts ... holes, and therefore risks falling victim to predators from both ... kept in any zoo. Prior to this research virtually ... that it has been classified as Critically Endangered, the top ...
... study published today in the journal Gondwana Research ... Antarctic and Indian tectonic plates, demonstrating how they formed ... from Royal Holloway University, The Australian National University and ... how the plates evolved and where they should be ...
... years, pilots flying into combat have jammed enemy radar to ... moths can do it, too. A new study co-authored ... pulses from their genitals to respond to bats producing the ... echolocation ability of their predators. Echolocation research may ...
Cached Biology News:Solitary lemurs avoid danger with a little help from the neighbors 2UF researcher shows hawkmoths use ultrasound to combat bats 2UF researcher shows hawkmoths use ultrasound to combat bats 3
(Date:8/20/2014)... (PRWEB) August 20, 2014 Not long ... E&L studies should be performed late in the development ... known. But current regulatory trends suggest that, like many ... the rise. In recent years, multiple drug sponsors have ... or address specific questions during phase I/II. It’s not ...
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/20/2014)... WriteResult®, a leading provider of Electronic Patient ... its myPROpad™ ePRO tablet with the addition of a ... most widely used and well-respected Patient Reported Outcome (PRO) ... is used during clinical trials and in other health ... used to demonstrate Health-Related Quality of Life outcomes (HRQoL) ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2'Tickling' your ear could be good for your heart 2EQ-5D™ Assessment Now Available for iPad 2
... Call Tomorrow (Tuesday) at 8:30 am EDT to ... Discuss the Clinical ... (NASDAQ: XTLB ; LSE: XTL; TASE: XTL) today announced,the initiation ... norepinephrine reuptake inhibitor (SNRI) - for the treatment of,diabetic neuropathic pain. ...
... CeloNova BioSciences, Inc.,("CeloNova"), a leading developer of ... fully color-coded line of embolic particles,Embozene(TM) Color-Advanced ... and Interventional Radiology Society of Europe (CIRSE) ... ) Embolic microspheres are used to ...
... 7 Monogram,Biosciences, Inc. (Nasdaq: MGRM ) announced ... to present a corporate overview at the,ThinkEquity Partners, G5: ... p.m. Eastern Time (10:30 a.m. Pacific Time) at the ... the live audio broadcast or the subsequent archived,recording, log ...
Cached Biology Technology:XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 2XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 3XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 4XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 5XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 6XTL Biopharmaceuticals Initiates Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 7CeloNova BioSciences Announces World's First Line of Fully Color-Coded Embolic Particles at CIRSE: Embozene(TM) Color-Advanced Microspheres 2Monogram Biosciences to Present at the ThinkEquity Partners' Fifth Annual Growth Conference 2
... KitTM allows graphic manipulation of DNA sequences ... an award winning interface design that allows ... to providing sophisticated drawing capabilities for Mac ... "Best Plasmid Mapping Software" by the Biotechnology ...
... ISO 9001:2000 Certified USDA Research Registered OLAW ... Training AALAS Certified Technicians ... GLP Documentation Upon Request Focus ... for all your custom immunology service needs. ...
... Quality ISO 9001:2000 Certified ... All Precedures Validated, SOP's Training ... Process for All Procedures GLP Documentation Upon ... one stop shopping point for all your ...
...
Biology Products: