Navigation Links
UC Davis researchers discover Achilles' heel in pancreatic cancer
Date:11/6/2008

reatic cell lines that represent the varying levels of argininosuccinate synthetase observed in human tumor specimens. Focusing on the lines with lowest levels, the researchers depleted arginine levels in cultures of pancreatic cell lines using arginine deiminase, an enzyme isolated from a Mycoplasma bacteria.

The enzyme was modified by adding polyethylene glycol chains to increase size and circulatory time.

The researchers found that exposing the pancreatic cancer cell lines to the modified arginine deiminase enzyme inhibited cancer-cell proliferation by 50 percent. They then treated mice bearing pancreatic tumors with the same compound and found an identical outcome: a 50 percent reduction in tumor growth. According to Bold, the current study represents a unique approach to cancer treatment in that it is one of the first to identify a metabolic pathway that can be leveraged to interrupt cancer growth.

"Instead of killing cells as with typical chemotherapy, we instead removed one of the key building blocks that cancer cells need to function," Bold said.

Metabolic interruptions like this one are also being studied for their potential in treating cancers of the blood, such as leukemia and lymphoma. In those cases, depleting the amino acid asparagine may be used in slowing cancer-cell growth.

Bold and his colleagues are continuing their laboratory work on the effects of arginine deprivation on pancreatic cancer. They will next be looking for ways to increase pancreatic cell sensitivity to arginine deprivation.

The researchers have also begun designing human clinical trials in cooperation with the manufacturer of arginine deiminase, Polaris Pharmaceuticals.

"We're looking at whether we can combine this treatment with certain kinds of chemotherapy," Bold said. "This additional research is needed to inform the clinical work and move it forward more quickly. The better we understand this process, the more we c
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis researchers discover a key to aggressive breast cancer
2. UC Davis chemical ecologist wins major award
3. UC Davis researchers discover new drug target for inflammatory disease
4. UC Davis researchers define characteristics, treatment options for XXYY syndrome
5. UC Davis researcher leads climate-change discovery
6. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
7. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
8. UC Davis bird-flu expert calls for changes in early-warning system
9. Repairing DNA damage: Researchers discover critical process in cancer treatment
10. Corn researchers discover novel gene shut-off mechanisms
11. Researchers at UH explore patient preferences for personalized medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... molecular testing panel developed at UPMC greatly increases ... for patients with thyroid nodules and cancer, report ... (UPCI), partner with UPMC CancerCenter., The test, available ... diagnostic testing agencies, improved the chances of patients ... according to the study published this month in ...
(Date:7/24/2014)... 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced ... control Phase 3 study of Zerenex (ferric citrate), the ... treatment of hyperphosphatemia in patients with end-stage renal disease ... iRon delivery with FErric CiTrate in EsrD) was published ... Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... disturbance has different effects on different species of ... Universities of Bristol and Exeter which tested fish ... to a flying seagull predator model when exposed ... in European minnows. , Lead author Dr ... said: "Noise levels in many aquatic environments have ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex™ (ferric citrate) long-term Phase 3 study results published in JASN 4
... conditions based on results from the previous day,s sample. Scientists ... lab to culture them for analysis a process that ... engineers from the UCLA Henry Samueli School of Engineering and ... concentrations to under one hour, through the development of a ...
... A new University of Illinois study touts the ... for starterssaying that it reduces the inflammation associated with ... fiber changes the personality of immune cellsthey go from ... help us recover faster from infection," said Gregory Freund, ...
... CAMBRIDGE, Mass., March 2, 2010 Fictional candy maker ... chocolate eggs from bad, an eggucator. Likewise, by determining ... discard, scientists are aiming to find their own golden ... Toward that end, Harvard researchers and a team ...
Cached Biology News:UCLA engineers develop faster method to detect bacterial contamination in coastal waters 2UCLA engineers develop faster method to detect bacterial contamination in coastal waters 3An apple a day? Study shows soluble fiber boosts immune system 2An apple a day? Study shows soluble fiber boosts immune system 3Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket 2Sorting device for analyzing biological reactions puts the power of a lab in a researcher’s pocket 3
(Date:7/24/2014)... -- ECC West Africa, LLC (ECC) signed a contract in ... Hospital (UCH) Ibadan Board of Management for the first ... and operate and maintain a new, state-of-the-art Cancer Institute ... first of the 4-phase project, ECC will conduct feasibility ... Ibadan intends to finance and develop the Cancer Institute ...
(Date:7/24/2014)... have yet to materialise. Yet, scientists are making ... computers faster. One such approach relies on quantum ... applying an electric field. A new study demonstrates ... quantum dots (TQDs) with electrical impulses can help ... should TQDs be used as quantum information units, ...
(Date:7/24/2014)... Research and Markets has announced the addition ... report to their offering.  http://photos.prnewswire.com/prnh/20130307/600769 ... vitro growth of plant or animal cells for several ... Cell culture is a crucial step in tissue engineering ... consumables are necessary for the in vitro production of ...
(Date:7/24/2014)... , July 24, 2014 SRI International ... with the National Institute of Allergy and Infectious Diseases ... conduct preclinical development of potential therapies for HIV infection ... to treat HIV and AIDS and the complications and ... microbicides for preventing sexual transmission of HIV. ...
Breaking Biology Technology:ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... , , , LEXINGTON, Mass. ... holding gmbh announced today the launch of the first human cancer ... targeted Next-Generation Sequencing (NGS). The new catalog cancer biochip features 115 ... of cancer by the Wellcome Trust Sanger Institute. , ...
... , , RARITAN, N.J., July 13 ... can accurately predict the prognosis and survival in patients ... published report in the July 10 issue of the ... retrospective study compared how well CTCs and a more ...
... , SAN MARINO, Calif., July 13 ... compounds for HIV/AIDS, autoimmune diseases, and cancer, has retired the majority ... other debt and recently issued new shares. , ... financing through the issuance of shares. This transaction originally was disclosed ...
Cached Biology Technology:First Catalog Cancer Biochip for Sequence Capture Now Available from febit 2Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 2Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 3Monitoring Circulating Tumor Cells With the CellSearch(R) System Can Predict Prognosis in Metastatic Breast Cancer 4Viral Genetics Retires Nearly $3.5 Million Convertible Debt and Provides Updates on Capital Structure and Stock Issuances 2Viral Genetics Retires Nearly $3.5 Million Convertible Debt and Provides Updates on Capital Structure and Stock Issuances 3
... number is a new product number, created ... showing no availability yet, please order under ... customer service for assistance. ID ... D H 100 20 mm ...
BD BioCoat Gelatin 100 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of gelatin....
Mouse monoclonal antibody raised against a full length recombinant ATF3. NCBI Entrez Gene ID = ATF3...
... Delivers 4,600 to Over 3 Million Genotypes ... is capable of performing 4,600 to over ... the GenomeLab family of products*, this automated, ... 48 SNPs in each well of an ...
Biology Products: