Navigation Links
UC Davis researchers discover Achilles' heel in pancreatic cancer
Date:11/6/2008

reatic cell lines that represent the varying levels of argininosuccinate synthetase observed in human tumor specimens. Focusing on the lines with lowest levels, the researchers depleted arginine levels in cultures of pancreatic cell lines using arginine deiminase, an enzyme isolated from a Mycoplasma bacteria.

The enzyme was modified by adding polyethylene glycol chains to increase size and circulatory time.

The researchers found that exposing the pancreatic cancer cell lines to the modified arginine deiminase enzyme inhibited cancer-cell proliferation by 50 percent. They then treated mice bearing pancreatic tumors with the same compound and found an identical outcome: a 50 percent reduction in tumor growth. According to Bold, the current study represents a unique approach to cancer treatment in that it is one of the first to identify a metabolic pathway that can be leveraged to interrupt cancer growth.

"Instead of killing cells as with typical chemotherapy, we instead removed one of the key building blocks that cancer cells need to function," Bold said.

Metabolic interruptions like this one are also being studied for their potential in treating cancers of the blood, such as leukemia and lymphoma. In those cases, depleting the amino acid asparagine may be used in slowing cancer-cell growth.

Bold and his colleagues are continuing their laboratory work on the effects of arginine deprivation on pancreatic cancer. They will next be looking for ways to increase pancreatic cell sensitivity to arginine deprivation.

The researchers have also begun designing human clinical trials in cooperation with the manufacturer of arginine deiminase, Polaris Pharmaceuticals.

"We're looking at whether we can combine this treatment with certain kinds of chemotherapy," Bold said. "This additional research is needed to inform the clinical work and move it forward more quickly. The better we understand this process, the more we c
'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis researchers discover a key to aggressive breast cancer
2. UC Davis chemical ecologist wins major award
3. UC Davis researchers discover new drug target for inflammatory disease
4. UC Davis researchers define characteristics, treatment options for XXYY syndrome
5. UC Davis researcher leads climate-change discovery
6. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
7. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
8. UC Davis bird-flu expert calls for changes in early-warning system
9. Repairing DNA damage: Researchers discover critical process in cancer treatment
10. Corn researchers discover novel gene shut-off mechanisms
11. Researchers at UH explore patient preferences for personalized medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31 de julho de 2015 A 10 ... ) será realizada pela BGI de 22-25 de outubro de ... A conferência está celebrando seu 10 o. ... ICG se tornou uma das reuniões mais influentes do ... científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... Conn. , Jul. 31, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... that it has filed provisional patent 62/198989 for ... This invention highlights a method to advance crypto-currencies such ... by introducing a common, uniform way to manage all ...
(Date:7/27/2015)... LOS ANGELES , July 27, 2015 /PRNewswire/ ... providing evidence- and experience-based clinical improvement solutions, today ... coordination solution is now available on Android smartphones ... at inpatient and post-care organizations can use ZynxCarebook ... the same patient,s condition, streamline care transitions to ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3
... simpler technique for testing public drinking water samples for ... reduce the amount of time required to conduct the ... Protection Agency (EPA) has approved use of the new ... Kahn, director of the Georgia Tech Research Institutes (GTRI) ...
... PITTSBURGH, Aug. 28 Gamma globulin, a type of ... routinely given to health care workers and international travelers ... effective treatment for pinkeye with little apparent toxicity, according ... Pittsburgh School of Medicine. The results of the study, ...
... September 2007 issue of the Journal of Lipid ... Renal transplant recipients genetic makeup does ... anti-inflammatory compound discovered Thematic Review: Understanding how obese fat ... recipients genetic makeup does not negatively impact fluvastatin use ...
Cached Biology News:Safe water: simpler method for analyzing radium in water samples cuts testing time 2Safe water: simpler method for analyzing radium in water samples cuts testing time 3Gamma globulin effective in treating eye infections caused by adenoviruses 2Story ideas from the Journal of Lipid Research 2Story ideas from the Journal of Lipid Research 3Story ideas from the Journal of Lipid Research 4Story ideas from the Journal of Lipid Research 5
(Date:7/30/2015)... Denmark , July 30, 2015 ... biotechnology company that applies its innovative TransCon technology ... positive top-line results from a six-month Phase 2 ... once-weekly TransCon Growth Hormone in 53 treatment-naïve, pre-pubertal ... "We are extremely pleased with the top-line ...
(Date:7/30/2015)... NH (PRWEB) , ... July 30, 2015 , ... ... homogenizer for advanced fluid applications and designed for continuous operation up to 1500 ... and sterilization-in-place, ensuring safety, efficiency, and preventing toxic contamination. , The Pony™ NS2006L ...
(Date:7/29/2015)... July 29, 2015 US-Australian drug discovery company, ... confirmed it is committed to progressing its ground-breaking technology ... practicable and to ensure the Company delivers the best ... Iain Ross , said the Company currently had ... pre-clinical programs, discovery programs and academic partnerships and initiatives, ...
(Date:7/29/2015)... 29, 2015  AsureQuality and Ubiquitome have agreed ... applications in food and primary production sectors. The ... PCR device, the Freedom4. AsureQuality provides ... the supermarket shelf for producers, processors and Competent ... animal disease control and pest management and surveillance ...
Breaking Biology Technology:Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7GEA Announces the Pony™ NS2006L… a Self-contained, High Pressure Lab Homogenizer for Product Development Ensuring Maximum Efficiency and Safety 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 2Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 3Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 4Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 5Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 6Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 7Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 8Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 9Newly Appointed Acting CEO Outlines Immediate Plans for Novogen 10AsureQuality and Ubiquitome Partner on Applications for Mobile Molecular Food Safety Testing 2
... JERUSALEM, Sept. 21 Chiasma, Inc., a privately ... CEO, will present an overview of the Company at the ... York, New York, on Wednesday, September 22, 2010 at 11:00 ... clinical trial of the investigational new drug Octreolin™, an oral ...
... Spain, Sept. 20 Talecris Biotherapeutics GmbH announced ... Laurell,s Training Awards (eALTA). The annual awards, sponsored ... to young investigators whose research aims to enhance ... deficiency). AAT deficiency is a rare, genetic condition ...
... KERX ) today announced that Ron Bentsur, the ... UBS Global Life Sciences Conference, being held at the Grand ... scheduled to take place on Wednesday, September 22, 2010, at ... Bentsur,s presentation will be accessible from the Investor Information page ...
Cached Biology Technology:Chiasma to Present at the UBS Global Life Sciences Conference 2Chiasma to Present at the UBS Global Life Sciences Conference 3Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 2Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 3Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 4Talecris Biotherapeutics GmbH Awards Winners of the 7th Annual European ALTA Research Fellowship at 2010 ERS Meeting 5Keryx Biopharmaceuticals to Present at the UBS 2010 Global Life Sciences Conference 2
TUNEL Apoptosis Detection Kit...
homeo box D3, mRNA...
SNARE associated protein snapin, clone MGC:2717...
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Biology Products: