Navigation Links
UC Davis researchers develop new drug delivery system for bladder cancer using nanoparticles
Date:10/25/2012

(SACRAMENTO, Calif.) -- A team of UC Davis scientists has shown in experimental mouse models that a new drug delivery system allows for administration of three times the maximum tolerated dose of a standard drug therapy for advanced bladder cancer, leading to more effective cancer control without increasing toxicity.

The delivery system consists of specially designed nanoparticles that home in on tumor cells while carrying the anti-cancer drug paclitaxel. The same delivery system also was successfully used to carry a dye that lights up on imaging studies, making it potentially useful for diagnostic purposes. The findings are published today in the journal Nanomedicine.

"We have developed a novel, multifunctional nanotherapeutics platform that can selectively and efficiently deliver both diagnostic and therapeutic agents to bladder tumors," said Chong-Xian Pan, principal investigator of the study and associate professor of hematology and oncology at UC Davis. "Our results support its potential to be used for both diagnostic and therapeutic applications for advanced bladder cancer."

Cancer of the bladder usually develops in the cells of the inner lining of the bladder. Survival rates are high if the disease is caught early, but it remains difficult to treat in advanced stages ― when the tumor has grown outside of the bladder or metastasized to distant sites. It is the fourth most common cancer in men; it occurs less frequently in women.

Paclitaxel is a drug used to treat advanced bladder cancer and other cancers, but it is associated with serious safety concerns. It can be toxic to bone marrow, leading to reduced levels of red and white blood cells, putting patients at risk of infection. In addition, because the drug is not readily soluble in blood, it is typically dissolved in castor oil, which has caused severe ― and sometimes fatal ― allergic reactions.

The drug delivery system used in thi
'/>"/>

Contact: Dorsey Griffith
dorsey.griffith@ucdmc.ucdavis.edu
916-734-9118
University of California - Davis Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Davis study finds that above-normal weight alone does not increase the short-term risk of death
2. UC Davis scientists find new role for P53 genetic mutation -- initiation of prostate cancer
3. Far from random, evolution follows a predictable genetic pattern, Princeton researchers find
4. USF researchers identify gene mutation linked to old age hearing loss
5. USDA scientists collaborate with global researchers to advance the mapping of the barley genome
6. Danish researchers release ground-breaking knowledge about calcium pumps in cells
7. CU-Boulder researchers uncover new target for cancer research
8. Columbia researchers report novel approach for single molecule electronic DNA sequencing
9. Researchers develop new stamping process to pattern biomolecules at high resolution
10. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
11. RUB researchers clarify catalysis mechanism of cell growth protein Ras
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... newborn immune T cells may have the ability to ... new study led by King,s College London. Although their ... babies may still be able to mount a strong ... Nature Medicine . , Our immune system is ... including neutrophils which play an important role in the ...
(Date:9/19/2014)... unveiled today by researchers from several Harvard University ... both experienced and aspiring researchers with the intellectual ... robots made from soft, flexible materials. , With ... and other advances in manufacturing technology, soft robotics ... principles drawn from conventional rigid robot design, but ...
(Date:9/19/2014)... species which over thousands of years has adapted to the ... that makes the cold dangerous for you. , This is ... and the cold provoking substance, called nonylphenol, comes from the ... suspected of being a endocrine disruptor, but when entering the ... ability to protect the cells in its body from cold ...
Breaking Biology News(10 mins):Immune system of newborn babies is stronger than previously thought 2Soft robotics 'toolkit' features everything a robot-maker needs 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... to act cancerous, surviving, growing and reproducing out of ... characteristics to stop growing or to die. In breast ... sometimes promoting tumors and sometimes suppressing them. A ... the journal Oncogene details how tumors may ...
... of Texas at Austin researchers have demonstrated a new ... the heart and limbs a research advancement that ... disease, the leading cause of death in the Western ... of Engineering Assistant Professor Aaron Baker could allow doctors ...
... available in German . The Deutsche ... four new Research Units. This decision was taken by the ... of the research consortia is to offer researchers the opportunity ... and to establish innovative research directions. As with ...
Cached Biology News:Study details on-off switch that promotes or suppresses breast cancer 2New ability to regrow blood vessels holds promise for treatment of heart disease 2New ability to regrow blood vessels holds promise for treatment of heart disease 3DFG to establish 4 new research units 2DFG to establish 4 new research units 3
(Date:9/22/2014)... , September 22, 2014 ... on a mixed note as the Dow Jones Industrial ... Composite closed at 4,579.79, down 0.30%. The S&P 500 ... trading session, six out of ten sectors finished on ... Index ended the day at 751.48, up 0.10%, with ...
(Date:9/22/2014)... 2014  Spherix Incorporated (SPEX) -- an intellectual property development ... today announced that the United States Patent & Trademark Office ... month of September that is part of a standard essential ... USRE45,121 , Application number: US 13/728,867 , ... 27, 2012 The listed inventors of the ...
(Date:9/21/2014)... Chemical Sciences play a significant role in meeting ... safe water, healthy food, and dependable medicine from ... educators, and scientists have a great role in ... for the national development, and to foster research ... emerging Sciences, accelerating with a tremendous speed to ...
(Date:9/20/2014)... 20, 2014 MediVet America ... a groundbreaking surgery at the specialized Wolvega Horse Clinic. ... digital flexor tendon was ruptured 90% and her deep ... is a death sentence for a horse. , The ... cell treatments . This revolutionary regenerative option for ...
Breaking Biology Technology:Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 2Spherix Notified by United States Patent & Trademark Office of New Standard Essential Patent Issued to Spherix 3Chemistry for Global Development during the Open Access Week 2Chemistry for Global Development during the Open Access Week 3World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 2World’s first tendon replacement using Nanofiber and activated MediVet Stem Cell Fraction 3
... 24 Huntsman Advanced Materials, a division ... announced it was awarded the JEC Award for innovative ... Huntsman received the award for the innovative use of ... with its US-based customer GrafTech International.Andre Genton, President of ...
... S.A. and,Solvay Pharmaceuticals Marketing and Licensing AG (subsidiary ... partnership agreement for the,promotion and distribution of Stallergenes ... of Independent States (CIS). , ... and a strong demand on the,part of the ...
... than 80% of Nearly 4,000 Participants Attend InformexUSA ... Chemical IndustryPRINCETON, N.J., March 24 In a ... the United States -- InformexUSA -- visitors affiliated ... said they remain on the look-out for new ...
Cached Biology Technology:Huntsman Innovation Wins Top Award at Paris JEC Show 2Stallergenes Signs an Exclusive Partnership Agreement With Solvay Pharmaceuticals for the Promotion and Distribution of its Products in Russia and the CIS* 2Stallergenes Signs an Exclusive Partnership Agreement With Solvay Pharmaceuticals for the Promotion and Distribution of its Products in Russia and the CIS* 3Informex Survey Shows Innovation Remains a Priority for 2009 and Beyond 2Informex Survey Shows Innovation Remains a Priority for 2009 and Beyond 3
Rabbit polyclonal to Aortic Elastin ( Abpromise for all tested applications). entrezGeneID: 2006 SwissProtID: P15502...
Anti-gp120/160(SIV/mac239) Immunogen: gp120(SIV/mac239) protein (Genebank accession #M33262)...
Tropomyosin 4 [Tm4]...
...
Biology Products: