Navigation Links
UC Davis research shows that newly discovered drug reduces heart enlargement
Date:1/29/2009

DAVIS--Researchers at the University of California, Davis have discovered that a prototype drug reduces heart enlargement, one of the most common causes of heart failure.

Heart failure, which occurs when the heart can't pump enough blood throughout the body, affects 5 million people in the United States. The condition contributes to 300,000 deaths each year.

The research in the laboratories of cardiologist and cell biologist Nipavan Chiamvimonvat, Department of Cardiovascular Medicine, UC Davis School of Medicine, and entomologist Bruce Hammock, Department of Entomology, showed that the new class of drugs reduces heart swelling in rat models with heart failure.

"This holds promise to treat heart failure and other cardiovascular as well as kidney problems," said nephrology professor Robert Weiss, Department of Internal Medicine.

Similar compounds are now in clinical trials.

Ding Ai of Beijing, senior author of the paper published recently in the Proceedings of the National Academy of Sciences, worked as a Ph.D. student in the Chiamvimonvat and Hammock laboratories for a year.

"The study of rat models showed that heart failure is driven by high angiotensin associated with high blood pressure, artery disease and some kidney disease," Hammock said.

"When that occurs, a key enzyme called soluble epoxide hydrolase is increased."

The initial research on the enzyme sprang from studies on insect pest control in the Hammock lab.

"This enzyme," Chiamvimonvat said, "degrades anti-inflammatory and anti-hypertensive factors normally in the heart and blood, which may contribute to the pathological progression of heart failure."

Heart failure weakens the heart's pumping ability, she said. Blood and fluid can back up into the lungs; accumulate in the feet, ankles and legs (edema); and result in tiredness and shortness of breath. Coronary artery disease, high blood pres
'/>"/>

Contact: Kathy Keatley Garvey
kegarvey@ucdavis.edu
530-754-6894
University of California - Davis
Source:Eurekalert  

Page: 1 2

Related biology news :

1. UC Davis researchers find molecule that targets brain tumors
2. UC Davis discovery offers hope for treating kidney cancer
3. UC Davis team refines cancer treatments to reduce potential nerve damage
4. UC Davis researchers exploring gene therapy to fight AIDS
5. UC Davis researchers discover Achilles heel in pancreatic cancer
6. UC Davis researchers discover a key to aggressive breast cancer
7. UC Davis chemical ecologist wins major award
8. UC Davis researchers discover new drug target for inflammatory disease
9. UC Davis researchers define characteristics, treatment options for XXYY syndrome
10. UC Davis researcher leads climate-change discovery
11. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
UC Davis research shows that newly discovered drug reduces heart enlargement
(Date:7/31/2015)... , July 31, 2015 The 10 th ... be held by BGI from October 22-25, 2015, in ... The conference is celebrating its 10 th anniversary this ... of the world,s most influential annual meetings in the ,omics, ... enjoyable scientific gatherings. ICG-10 focuses on recent ...
(Date:7/27/2015)... 27, 2015   Zynx Health ™, the ... improvement solutions, today announced that its ZynxCarebook ... on Android smartphones and tablets. With this expansion, ... can use ZynxCarebook to securely exchange messages and ... care transitions to other care settings, and improve ...
(Date:7/21/2015)... , July 21, 2015 Today, ZTE announced ... received as well as expected revenues in 2015 that relate to ... communicated revenue guidance of approximately 2,200 MSEK for 2015. ... a leading smartphone manufacturer in China and ... 02 5 for Axon , ...
Breaking Biology News(10 mins):The 10th International Conference on Genomics (ICG-10) to Open in October 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... On April 15, 2010 , Dr. Stipkala joined a panel ... hosted by the University of South Carolina ,s NanoCenter in ... capitalists from all over the Southeast who are active in the nanotechnology ... Dr. Stipkala and ...
... Bethesda, MD The Genetics Society of America is ... selected for poster awards at the 51st Annual Drosophila ... were selected for first, second and third place awards ... undergraduate. This was the first time that undergraduate student ...
... YORK (April 25, 2010) -- Researchers at the ... Psychiatry at Weill Cornell Medical College discovered that ... behaviors. The genetically altered mice, which behaved much ... disorder (OCD), could help scientists design new therapies ...
Cached Biology News:Dr. Jeremy M. Stipkala, Patent Attorney, Speaks on USC NanoCenter Panel 2Genetics Society of America announces award recipients at 51st Annual Drosophila Conference 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 2Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 3Weill Cornell researchers find that a single gene is responsible for OCD-like behaviors in mice 4
(Date:7/31/2015)... ... , ... R-Biopharm is proud to announce the RIDASCREEN® Gliadin ... has been accepted by AOAC International as Official First Action method. The AOAC ... by R5 Competitive ELISA,” based on a specific monoclonal antibody to potentially celiac ...
(Date:7/30/2015)... AACC welcomed thousands of medical professionals ... Meeting & Clinical Lab Expo in ... showcased revolutionary advancements in clinical testing technology and ... to diagnose patients quickly and accurately and make ... As of Wednesday, July 29, more than ...
(Date:7/30/2015)... ... July 30, 2015 , ... Tronics, ... as Sales & Marketing Director. , With more than 25 years of ... for reinforcing Tronics’ business development activities worldwide. He brings to the company his ...
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... "Biosimulation Market, by Product (Software, Molecular Modeling, PB/PK, PKPD, ... (Drug Discovery & Development, Preclinical, Clinical Trial), by End ... the Biosimulation Market is expected to reach USD 2,107.99 ... at a CAGR of 15.29%. Browse ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4
... , , Akira Ichikawa and Seiji Igarashi , ... , Introduction ... the most consistently , used mutation scanning methods. It ... be widely used particularly in gene diagnostic laboratories. , ...
... Axel Reinecke-Lthge*, Barbara Mllmann*, Angela , Kellner, ... of Pathology and Department of Hematopathology, Christian- , ... , ... the cause underlying many non-neoplastic , and ...
... Glenn A. Miller, Ph.D., Molecular Profiling Laboratory, Genzyme, ... Introduction , ... study of genes that play a role in the development ... single and multiple gene disorders. A wide variety of different , ...
Cached Biology Technology:Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System 2Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System 3Detection of K-ras Point Mutations in the Pancreas by Constant Denaturing Gel Electrophoresis Using the DCode System 2Detection of K-ras Point Mutations in the Pancreas by Constant Denaturing Gel Electrophoresis Using the DCode System 3Detection of K-ras Point Mutations in the Pancreas by Constant Denaturing Gel Electrophoresis Using the DCode System 4A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 2A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 3A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 4A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 5A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 6A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 7A Multiple Mutation Model System as a Test Development and Training Tool for Denaturing Gradient Gel Electrophoresis 8
... / Mount is the standard water based ... especially for the permanent preservation of peroxidase ... is easy to use and exhibits excellent ... first aqueous mounting medium that permits the ...
... Immunogen: Synthetic peptide derived from an ... protein. Specificity: Specific for the ... WNT2B/WNT13 proteins. Recognizes both human WNT13A ... Human Rat (positive controls: mouse WNT2B/WNT13-pCMV-tag2-transfected ...
Immunogen: Heat inactivated bacterial cells of Salmonella enteriditis,paratyphi and typhimurium Storage: 4 C...
Immunogen: Secretory component isolated from human colostrum. Storage: 4 C...
Biology Products: