Navigation Links
UC Davis discovery offers hope for treating kidney cancer
Date:12/23/2008

Kidney cancer is typically without symptoms until it has spread to other organs, when it is also the most difficult to treat. Newer chemotherapies show great promise for extending survival during later disease stages, but they can also be highly toxic.

In one of the first discoveries of its kind, UC Davis Cancer Center researchers have identified ways to block a cancer gene's own repair mechanism and, in so doing, help make chemotherapy for kidney cancer more effective and better tolerated. The outcome is published in the current issue of Cancer Biology and Therapy.

"Cancer cells are notorious in their ability to rapidly create copies of themselves. While the latest medications slow down that process, they do not tend to be curative and have many side effects," said Robert Weiss, a UC Davis professor of nephrology and chief of nephrology at the Sacramento VA Medical Center. "We wanted to find ways to help make chemotherapeutics as effective as possible at the lowest doses possible."

Newer medications work by destabilizing cancer cells at the DNA level, which reduces their ability to replicate. Knowing that the p21 gene has an important role in restoring cancer cell DNA and potentially circumventing the benefits of those treatments, Weiss sought to identify compounds that could interrupt this pathway.

The team tested thousands of compounds and 12 were found to bind to the recombinant protein p21. Additional tests showed that three of those compounds decreased p21 expression, blocking kidney cancer cells' ability to mend and making them more responsive to DNA-damaging treatments.

"The results are very exciting, especially given how difficult kidney cancer has so far been to treat," Weiss said. "Our work offers hope that in the future these p21 inhibitors can be refined and used in concert with other conventional as well as novel cancer treatments to increase the comfort and life spans of patients with kidney cancer."

For future studies, Weiss will focus on the three candidate compounds to determine the lowest possible concentrations at which they remain effective and to further optimize their anti-cancer properties. He will then test those compounds with standard treatments in animal models and, ultimately, in human trials.

"The goal is to find new approaches to treating a cancer for which few options currently exist and make those approaches available in clinical settings as quickly as possible," he said.


'/>"/>

Contact: Karen Finney
karen.finney@ucdmc.ucdavis.edu
916-734-9064
University of California - Davis - Health System
Source:Eurekalert

Related biology news :

1. UC Davis team refines cancer treatments to reduce potential nerve damage
2. UC Davis researchers exploring gene therapy to fight AIDS
3. UC Davis researchers discover Achilles heel in pancreatic cancer
4. UC Davis researchers discover a key to aggressive breast cancer
5. UC Davis chemical ecologist wins major award
6. UC Davis researchers discover new drug target for inflammatory disease
7. UC Davis researchers define characteristics, treatment options for XXYY syndrome
8. UC Davis researcher leads climate-change discovery
9. UC Davis stem researchers demonstrate safety of gene therapy using adult stem cells
10. UC Davis researchers discover how HIV turns food-poisoning into lethal infection
11. UC Davis bird-flu expert calls for changes in early-warning system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... SOTO, Kansas , March 3, 2016 ... Oncimmune,s Early CDT®-Lung, a blood test to aid ... cancer Early CDT®-Lung test to its clients ... Early CDT®-Lung test to its clients which include ... a leader in early cancer detection, today announced a ...
(Date:3/2/2016)... 2, 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ... "Global Biometrics as a Service Market ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ... as a Service Market 2016-2020" report ... Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has ...
(Date:3/1/2016)...  (RSAC Booth #3041) – True fraud costs business ... is lost to false positives, where good customers are ... At the RSA Conference 2016, NuData Security is calling for ... by devaluing the data fraudsters have in abundance in ... --> --> Cheap and readily ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... York, NY (PRWEB) , ... May 03, 2016 ... ... and NeuroTech NYC , the sensor and data driven conferences, will take place ... UnitedHealth's Vidya Raman-Tangella on incorporating technology -- including AR/VR, ...
(Date:5/3/2016)... ... ... According to world renowned prostate cancer surgeon, Dr. David B. Samadi ... main treatment options: surgery or radiation. Based on a patient’s goals, disease state, and ... doctors to administer higher doses of radiation to prostate cancer patients with ...
(Date:5/2/2016)... ... May 02, 2016 , ... Meister Media Worldwide launches its ... and added functionality give the agricultural world a taste of Meister Media Worldwide’s ... agriculture – from precision farming via satellites and Unmanned Aerial Vehicles (UAVs) to ...
(Date:4/29/2016)... ... ... The MIT bioLogic design team has won multiple A' Design Awards ... be applied to fabric and formed into living interfaces between body and environment. They ... The team harvested Natto cells and applied them to fabric with custom 3D printers.The ...
Breaking Biology Technology: