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UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants
Date:5/13/2009

nding them, known as the extracellular matrix, may be providing improper instructions to the cells. "If we can deliver a different matrix one that promotes the growth of healthy tissue our hope is that we can eliminate secondary surgeries," he said.

With $300,000 in funding from The Hartwell Foundation, Leach intends to engineer a porous, biodegradable material with the mechanical properties of bone that can be placed along the sutures as a substitute for the fragmented skull bones. His goal for the three-year term of the grant is to demonstrate the feasibility of this approach in laboratory rats.

"What we want to do is make a scaffold a material that the bone-forming cells can enter that supplies them with the proper directions for how much bone they should be forming and how fast they should be doing it," he said.

Leach will be collaborating with two colleagues at the UC Davis School of Medicine: Alice Tarantal, a professor of cell biology and human anatomy who has extensive experience in stem cell research, and Simeon Boyd, an associate professor of pediatrics, who is an internationally recognized expert on congenital anomalies of the head and face.


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Contact: Liese Greensfelder
lgreensfelder@ucdavis.edu
530-752-6101
University of California - Davis
Source:Eurekalert  

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UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants
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