Navigation Links
UBC researcher invents 'lab on a chip' device to study malaria
Date:2/28/2012

University of British Columbia researcher Hongshen Ma has developed a simple and accurate device to study malaria, a disease that currently affects 500 million people per year worldwide and claims a million lives.

Spread by mosquitoes, malaria is caused by a tiny parasite that infects human red blood cells. Ma and his team designed a "lab on a chip" device to better understand the changes in red blood cells caused by Plasmodium falciparum, the most common species of malaria parasites.

Ma explains the device will help those conducting laboratory research or clinical trials evaluate the efficacy of different compounds in treating malaria a disease that is increasingly resistant to drugs.

"Our results show that it's possible to precisely measure the stiffening of red blood cells caused by the parasite at various stages of infection," says Ma, assistant professor in the UBC departments of mechanical engineering and urologic sciences, and senior research scientist at the Vancouver Prostate Center.

Normal human red blood cells must squeeze through capillaries many times smaller than their own diameter in order to deliver oxygen to all tissues in the body. Red blood cells infected with malaria gradually lose this capability, which disrupts blood flow, causing failure of vital organs and eventually death.

Measuring 2" x 1" (50 cm x 25 cm), Ma's microfluidic device deforms single red blood cells through a series of funnel-shaped constrictions. The pressure required to push the cell through each constriction is measured and then used to calculate the cell's deformability.

By measuring the deformability of an infected red blood cell, researchers can obtain vital information about the status of the disease and response to treatment, explains Ma, whose findings appear in the current issue of the journal Lab on a Chip.

Ma notes that although there has been considerable research on the biomechanic
'/>"/>

Contact: Lorraine Chan
lorraine.chan@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. Researchers find animal with ability to survive climate change
4. Researchers find an essential gene for forming ears of corn
5. Researchers note differences between people and animals on calorie restriction
6. Researcher working on destruction of chemical weapons
7. Researchers study acoustic communication in deep-sea fish
8. Researchers discover that growing up too fast may mean dying young in honey bees
9. Researchers study how pistachios may improve heart health
10. UI researchers find potentially toxic substance present in Chicago air
11. Researchers develop new self-training gene prediction program for fungi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/10/2015)... NEW YORK , March 10, 2015  Continuing ... and the Unexpected, Hammacher Schlemmer introduces The Eye ... user,s identity before granting access to secure websites or ... trusted to verify travelers at international borders, the device ... 240 distinctive pattern points of the iris, converting them ...
(Date:3/4/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/48tj8z/global_biometrics ) ... Biometrics Market Forecast and Opportunities, 2020" report ... biometric authentication systems is projected to grow at ... The driving forces for this highly competitive ... and constant development in technology. In 2014, government ...
(Date:2/25/2015)... LITTLE ROCK, Ark. , Feb. 25, 2015 ... of software and billing in the Health and ... software as well as to MYiCLUBonline.  The latest ... MYiCLUBonline and the inclusion of cardless check-in via ... demonstrated for the first time through interactive displays ...
Breaking Biology News(10 mins):Hammacher Schlemmer Introduces The Eye Scanning Password Authenticator 2Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3
... used, for example, to functionally characterize ,orphan, receptors those ... and thus qualify them as potential targets for drug ... libraries in order to identify and refine potential new drugs ... and are responsible for sensing the presence of hormones and ...
... COLUMBIA, Mo. If finding the cure for a ... subject of a detective show, University of Missouri Chemistry Professor ... using high-tech equipment to make a model that could eventually ... College of Arts and Science, has joined forces with Pablo ...
... CINCINNATI - A newly identified regulatory process affecting the ... new approaches to explore the causes of autoimmunity and ... of publication in Proceedings of the National Academy ... Children,s Hospital Medical Center report a novel process of ...
Cached Biology News:OGI invests in drug discovery at InDanio Bioscience 2X-ray diffraction may play key role in stopping 'kissing bug,' fungus 2Novel regulatory process for T cells may help explain immune system diseases 2
(Date:3/26/2015)... Ale Gicqueau, Founder and President of Clinovo, will ... Align Technology, on “ Conducting Postmarket Registries - Rationale ... Conference and Exhibition on April 25th through April 28th ... poster presentation, Ale Gicqueau and Victor Chen will discuss ... the requirements and resources to conduct the registry, as ...
(Date:3/25/2015)... Optimal Research, LLC has been nominated as ... "Best Clinical Site or Trial Network". This ... selected as a nominee in this ViE award category ... distinction in 2014. The ViE awards were created to ... positive contributions of companies and individuals in the vaccine ...
(Date:3/25/2015)... CAMBRIDGE, Mass. and REYKJAVIK, Iceland ... comprehensive capabilities for using the genome to create better medicine, ... of the largest studies of whole-genome data yet undertaken. ... Nature Genetics – are built around the ... by a team of deCODE scientists led by Kari ...
(Date:3/25/2015)... Researchers at Ancon Medical Inc. have ... enable broader and less invasive screening for cancer, ... breath screen. The Minnesota-based medical device maker will ... Administration (FDA) approval process and is targeting a ... Tagging device. , Ancon Medicals nanoparticle breakthrough comes ...
Breaking Biology Technology:Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2Landmark deCODE Studies Demonstrate the Power of Truly Big Genomics for Improving Medicine Worldwide 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 2Ancon Medical Researchers Make Nanotechnology Breakthrough for Disease Screening Technology 3
... Inc. (Nasdaq: OREX ), a biopharmaceutical company ... Jay Hagan has joined the organization as Senior Vice ... over 15 years of biotechnology operating and business development ... a significant number of important transactions. We are ...
... LYNBROOK, N.Y., May 11 BioSpecifics Technologies Corp. ... developing first in class collagenase-based products, today announced ... March 31, 2009. "The FDA,s recent acceptance of ... Priority Review for Dupuytren,s disease represents the culmination ...
... Barnard, has been awarded the International Union of Pure ... Computational Physics. , The award acknowledges Dr Barnard as ... the structures, shapes and crystal structures of materials at ... Melbourne Institute of Technology (RMIT) University in 2001 ...
Cached Biology Technology:Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 2Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 3Orexigen(R) Therapeutics Announces Jay Hagan as Senior Vice President, Corporate Development and Strategy 4BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 2BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 3BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 4BioSpecifics Technologies Corp. Reports First Quarter 2009 Financial Results 5Big prize for 'small science' physicist 2
Request Info...
Request Info...
Detect and measure levels of mouse IgG2b antibody isotypes quickly and easily....
Detect and measure levels of mouse IgG3 antibody isotypes quickly and easily....
Biology Products: