Navigation Links
UBC researcher invents 'lab on a chip' device to study malaria
Date:2/28/2012

University of British Columbia researcher Hongshen Ma has developed a simple and accurate device to study malaria, a disease that currently affects 500 million people per year worldwide and claims a million lives.

Spread by mosquitoes, malaria is caused by a tiny parasite that infects human red blood cells. Ma and his team designed a "lab on a chip" device to better understand the changes in red blood cells caused by Plasmodium falciparum, the most common species of malaria parasites.

Ma explains the device will help those conducting laboratory research or clinical trials evaluate the efficacy of different compounds in treating malaria a disease that is increasingly resistant to drugs.

"Our results show that it's possible to precisely measure the stiffening of red blood cells caused by the parasite at various stages of infection," says Ma, assistant professor in the UBC departments of mechanical engineering and urologic sciences, and senior research scientist at the Vancouver Prostate Center.

Normal human red blood cells must squeeze through capillaries many times smaller than their own diameter in order to deliver oxygen to all tissues in the body. Red blood cells infected with malaria gradually lose this capability, which disrupts blood flow, causing failure of vital organs and eventually death.

Measuring 2" x 1" (50 cm x 25 cm), Ma's microfluidic device deforms single red blood cells through a series of funnel-shaped constrictions. The pressure required to push the cell through each constriction is measured and then used to calculate the cell's deformability.

By measuring the deformability of an infected red blood cell, researchers can obtain vital information about the status of the disease and response to treatment, explains Ma, whose findings appear in the current issue of the journal Lab on a Chip.

Ma notes that although there has been considerable research on the biomechanic
'/>"/>

Contact: Lorraine Chan
lorraine.chan@ubc.ca
604-822-2644
University of British Columbia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. Researchers find animal with ability to survive climate change
4. Researchers find an essential gene for forming ears of corn
5. Researchers note differences between people and animals on calorie restriction
6. Researcher working on destruction of chemical weapons
7. Researchers study acoustic communication in deep-sea fish
8. Researchers discover that growing up too fast may mean dying young in honey bees
9. Researchers study how pistachios may improve heart health
10. UI researchers find potentially toxic substance present in Chicago air
11. Researchers develop new self-training gene prediction program for fungi
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... puberty is influenced by ,imprinted genes,a subset of genes whose ... This is the first evidence that imprinted genes can control ... study were published today in the journal Nature . ... a marker for the timing of puberty in females. ... girls, is an inherited trait, and is linked to breast ...
(Date:7/25/2014)... a molecular testing panel developed at UPMC greatly ... surgery for patients with thyroid nodules and cancer, ... Institute (UPCI), partner with UPMC CancerCenter., The test, ... other diagnostic testing agencies, improved the chances of ... percent, according to the study published this month ...
(Date:7/25/2014)... July 25, 2014 Biometrics industry ... turning to digital technology for online & commerce payments ... Inc. (NASDAQ: GOOG ), LifeLock Inc. (NYSE: ... V ), Apple Inc. (NASDAQ: AAPL ) ... (OTCQB: NXTD) a biometric authentication company focused on the ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6
... the AAAS Symposium, "Emerging Threats and Research Challenges ... 10:30. William Laurance, senior staff scientist ... moderator, recently co-organized a major event, "Debating the ... Natural History in Washington, which was featured in ...
... used in biomedicine and engineering likely won,t cause unexpected ... presented today. The result should allay fears that cells ... finest silica nanomaterials in industrial or commercial applications. ... size doesn,t matter, by using total surface area as ...
... simple, chemical materials model may lead to a better ... according to a Penn State researcher. "Cells are interesting ... the cytoplasm, and while it is thought to be ... how this organization is achieved," said Christine Keating, associate ...
Cached Biology News:AAAS Symposium: Emerging threats to tropical, temperate and ocean ecosystems 2Nanoparticle toxicity doesn't get wacky at the smallest sizes 2Nanoparticle toxicity doesn't get wacky at the smallest sizes 3Artificial cells, simple model for complex structure 2Artificial cells, simple model for complex structure 3
(Date:7/25/2014)... 25, 2014 WABC Radio show out of ... with Lorry Young will be hosting California-based Vet-Stem, Inc.’s Founder ... cell therapy in pets. Dr. Harman first visited the ... cell therapy for pets suffering from osteoarthritis and other degenerative ... Medicine industry forward. , Young has invited Dr. Harman back ...
(Date:7/25/2014)... 2014 /PRNewswire-iReach/ -- Xybion Corporation, the leading provider ... operating in highly regulated industries, announced today that ... User Group Conference, Xybion International Exchange, on October ... at the Sheraton Society Hill Hotel.  ... This year,s conference theme is Compliance ...
(Date:7/24/2014)... -- A novel combination of microscopy and data processing ... Ridge National Laboratory an unprecedented look at the surface ... electrochemical properties. , The research team led by ... of a perovskite manganite, a complex material that exhibits ... understand surface behavior could benefit researchers who are interested ...
(Date:7/24/2014)... July 24, 2014  ECC West Africa, LLC (ECC) ... with University College Hospital (UCH) Ibadan Board of ... to finance, design, construct, and operate and maintain a ... . Under the first of the 4-phase project, ... and funding applications. UCH Ibadan intends to finance and ...
Breaking Biology Technology:Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3ORNL study reveals new characteristics of complex oxide surfaces 2ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... ARIUS Research Inc., (TSX:,ARI), a biotechnology company ... therapeutics, today announced its financial and operational,results ... ended May 31st, 2008., "Throughout the ... moving,ARIUS, anti-cancer antibodies towards human clinical trial. ...
... , The white blood cells in our body combat ... leukemia, the formation of white blood cells is disturbed: ... multiply out of control without fully maturing. This process ... more susceptible to infections. T-ALL, a particular form of ...
... electronic device is an important step toward helping astronomers ... universe. This invisible light makes up 98% of the ... insights into the earliest stages of star and galaxy ... new circuit, developed by physicsts at Rutgers University, NASA,s ...
Cached Biology Technology:ARIUS announces second quarter fiscal 2008 financial results 2ARIUS announces second quarter fiscal 2008 financial results 3ARIUS announces second quarter fiscal 2008 financial results 4ARIUS announces second quarter fiscal 2008 financial results 5ARIUS announces second quarter fiscal 2008 financial results 6ARIUS announces second quarter fiscal 2008 financial results 7ARIUS announces second quarter fiscal 2008 financial results 8ARIUS announces second quarter fiscal 2008 financial results 9ARIUS announces second quarter fiscal 2008 financial results 10ARIUS announces second quarter fiscal 2008 financial results 11ARIUS announces second quarter fiscal 2008 financial results 12ARIUS announces second quarter fiscal 2008 financial results 13ARIUS announces second quarter fiscal 2008 financial results 14ARIUS announces second quarter fiscal 2008 financial results 15Not the protein, but its location in the cell, determines the onset of leukemia 2Nano-sized electronic circuit promises bright view of early universe 2Nano-sized electronic circuit promises bright view of early universe 3
RAB32, member RAS oncogene family, mRNA (cDNA clone MGC:13500 IMAGE:4280407), complete cds...
EDTA, 0.5 M solution, 100 ml. Ethylene diaminetetraacetic acid.Sterile, nuclease-free. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Human VEGF-D Biotinylated MAb (Clone 78923)...
One-step, microplate or cuvet, colorimetric, linear detection range 0.2 mg/dL to 20 mg/dL. Procedure: 20 min....
Biology Products: