Navigation Links
UBC geneticist reveals molecular view of key epigenetic regulator
Date:12/9/2009

In a paper published this week in the journal Proceedings of the National Academy of Sciences, Dr. Michael Kobor reported the structure and function of a key player in regulating chromatin in yeast and humans.

Kobor is a UBC assistant professor of medical genetics and a scientist at The Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute.

Chromatin, a dynamic DNA-protein complex, is involved in numerous cellular processes and has profound effects on human health and disease. This study is a major advancement in elucidating the role and structure of an epigenetic regulator commonly involved in human leukemia and other human diseases.

Chromatin biology is central to epigenetics which is a framework for environmental regulation of genome function. The chromatin regulator Yaf9 contains a module called the YEATS domain, which is found in many other proteins implicated in chromatin regulation and cancer. The molecular structure and function of YEATS domain proteins has been an unresolved mystery in the field of epigenetics.

Using advanced X-ray crystallography, the team gained the first detailed picture at atomic resolution of the YEATS domain. Furthermore, the authors showed that its function is conserved from yeast to human, and revealed a requirement of the YEATS domain for two different mechanisms by which chromatin can be modified.


'/>"/>

Contact: Nicki Kahnamoui
nicki@cmmt.ubc.ca
604-771-6908
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Geneticists coordinate action to fight against traffic in human beings
2. UC Riverside geneticist receives highest honor from Botanical Society of America
3. Is love at first sight real? Geneticists offer tantalizing clues
4. Ancient African exodus mostly involved men, geneticists find
5. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
6. UC Riverside rice geneticist receives high honor from US Department of Agriculture
7. Geneticist Francis Collins named first recipient of Inamori Ethics Prize at Case Western Reserve
8. Columbia geneticists uncover new gene involved in determining hair texture and density in humans
9. Plant geneticists find veritas in vino
10. Study reveals how Arctic food webs affect mercury in polar bears
11. Research reveals exactly how coughing is triggered by environmental irritants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... ARMONK, N.Y. and ITHACA, N.Y. ... IBM ) and Cornell University, a leader in dairy ... combined with bioinformatics designed to help reduce the chances ... breaches. With the onset of this dairy project, Cornell ... the Consortium for Sequencing the Food Supply Chain, a ...
(Date:5/16/2017)... DALLAS , May 16, 2017   ... for health organizations, and MD EMR Systems ... certified development partner for GE, have established a ... Patient Portal product and the GE Centricity™ products, ... Centricity EMR. These new integrations ...
(Date:4/18/2017)...  Socionext Inc., a global expert in SoC-based imaging and computing ... M820, which features the company,s hybrid codec technology. A demonstration utilizing ... Inc., will be showcased during the upcoming Medtec Japan at Tokyo ... Las Vegas Convention Center April 24-27. ... Click here for an image ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Disappearing forests and increased emissions ... over 5.5 million people each year. Especially those living in larger cities are affected ... based in one of the most pollution-affected countries globally - decided to take action. ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO ... Diego Rotary Club. The event entitled “Stem Cells and Their Regenerative ... attendees. Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. ...
(Date:10/10/2017)... ... October 10, 2017 , ... USDM ... firm for the life sciences and healthcare industries, announces a presentation by Subbu ... , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present a ...
Breaking Biology Technology: