Navigation Links
UBC geneticist reveals molecular view of key epigenetic regulator
Date:12/9/2009

In a paper published this week in the journal Proceedings of the National Academy of Sciences, Dr. Michael Kobor reported the structure and function of a key player in regulating chromatin in yeast and humans.

Kobor is a UBC assistant professor of medical genetics and a scientist at The Centre for Molecular Medicine and Therapeutics at the Child & Family Research Institute.

Chromatin, a dynamic DNA-protein complex, is involved in numerous cellular processes and has profound effects on human health and disease. This study is a major advancement in elucidating the role and structure of an epigenetic regulator commonly involved in human leukemia and other human diseases.

Chromatin biology is central to epigenetics which is a framework for environmental regulation of genome function. The chromatin regulator Yaf9 contains a module called the YEATS domain, which is found in many other proteins implicated in chromatin regulation and cancer. The molecular structure and function of YEATS domain proteins has been an unresolved mystery in the field of epigenetics.

Using advanced X-ray crystallography, the team gained the first detailed picture at atomic resolution of the YEATS domain. Furthermore, the authors showed that its function is conserved from yeast to human, and revealed a requirement of the YEATS domain for two different mechanisms by which chromatin can be modified.


'/>"/>

Contact: Nicki Kahnamoui
nicki@cmmt.ubc.ca
604-771-6908
University of British Columbia
Source:Eurekalert

Page: 1

Related biology news :

1. Geneticists coordinate action to fight against traffic in human beings
2. UC Riverside geneticist receives highest honor from Botanical Society of America
3. Is love at first sight real? Geneticists offer tantalizing clues
4. Ancient African exodus mostly involved men, geneticists find
5. Powerful online tool for protein analysis provided pro bono by Stanford geneticist
6. UC Riverside rice geneticist receives high honor from US Department of Agriculture
7. Geneticist Francis Collins named first recipient of Inamori Ethics Prize at Case Western Reserve
8. Columbia geneticists uncover new gene involved in determining hair texture and density in humans
9. Plant geneticists find veritas in vino
10. Study reveals how Arctic food webs affect mercury in polar bears
11. Research reveals exactly how coughing is triggered by environmental irritants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... Research and Markets has announced the addition ... their offering. ... tracking market to grow at a CAGR of 30.37% during the ... 2017-2021, has been prepared based on an in-depth market analysis with ... its growth prospects over the coming years. The report also includes ...
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:3/30/2017)... The research team of The Hong Kong ... identification by adopting ground breaking 3D fingerprint minutiae recovery and matching ... and accuracy for use in identification, crime investigation, immigration control, security ... ... A research team led by ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... conjugate (ADC) therapeutics, today confirmed licensing rights that give it exclusive global ... technology developed in collaboration with Children’s Hospital Los Angeles (CHLA). Additionally, ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
(Date:10/10/2017)... CRUZ, Calif. , Oct. 10, 2017 ... grant from the NIH to develop RealSeq®-SC (Single Cell), ... kit for profiling small RNAs (including microRNAs) from single ... Analysis Program highlights the need to accelerate development of ... "New techniques for measuring ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program Committee ... honoring scientists who have made outstanding contributions to analytical chemistry and applied ... the world’s leading conference and exposition for laboratory science, which will be held ...
Breaking Biology Technology: