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UAlberta researchers examine metabolism in defective cells
Date:4/11/2014

UAlberta researchers are taking a closer look at how two metabolic pathways interact to increase the lifespan of cells with mitochondrial defects. Magnus Friis is the lead author of the study, which was published online on April 10 and will be published in the April 24 issue of Cell Reports.

Mitochondria produce energy for cells through oxidative metabolism, but the process produces toxic byproducts that can accumulate and cause defects in the cell's mitochondria. These defects, in turn, affect the cell's ability to generate energy and can potentially lead to cell death and are associated with aging and various neurological diseases.

Friis, a postdoctoral fellow in Mike Schultz's biochemistry lab, examined how dietary changes at the cell level can affect cell health. He exposed normal and defective yeast cells to two different energy sources: glucose, the preferred sugar of cells, and raffinose, a natural sugar found in vegetables and whole grains.

"[The dietary intervention] is a general shift in what we're feeding the cells to get them to do something different with their whole nutrient metabolism," Friis noted. "There are signaling pathways that allow a cell to sense its environment and co-ordinate events to allow the cell to adapt to what's going on. In this case, [cells are responding to] which nutrients are available."

Friis and Schultz examined two nutrient signaling pathways called the AMPK pathway and the retrograde response. AMPK responds to energy deficits in the cell by down-regulating energy consuming processes, which are often associated with cell growth, and up-regulating energy producing processes. The retrograde response pathway is specific to the yeast used in the study and supplies key amino acids to the cell by changing the metabolic process of the mitochondria.

When activated individually, neither the AMPK pathway nor the retrograde response provided substantial benefits to cells with da
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Contact: Amy Hewko
ahewko@ualberta.ca
780-492-0647
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

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