Navigation Links
UAB study reveals bone coupling factor key to skeletal health
Date:7/8/2009

BIRMINGHAM, Ala. Researchers at the University of Alabama at Birmingham (UAB) have discovered a molecular coupling factor that helps bones grow and remodel themselves to stay strong, a finding that could lead to better bone-building therapies and new osteoporosis drugs, the researchers said

The coupling factor is a human protein called transforming growth factor beta-1, or TGF beta-1. Previously, scientists had searched for but missed the biological link between bone growth and bone remodeling a natural give-and-take system that is crucial to skeletal health. The discovery is reported online in the journal Nature Medicine.

"For the first time, we've identified TGF beta-1 is a coupling mechanism for bone resorption and bone formation," said Xu Cao, Ph.D., a professor in the UAB Department of Pathology and the study's senior author. "Osteoporosis, Paget's bone disease, Camurati-Engelmann disease, and many more, all involve a bone coupling disorder to some degree."

Previous research has hinted at but failed to explain the coupling role of TGF beta-1 in skeletal health. Bone remodeling occurs through resorption, the body's way of removing old and brittle bone to avoid breaks and skeletal disorders. Bone formation happens as skeletons grow and as the body works to counter bone resorption by laying down new bone.

Cao and his fellow researchers studied mice with Camurati-Engelmann disease, a genetic disorder that causes haphazard bone formation and poor skeletal health. They found the presence of TGF beta-1 in the mice could balance bone resorption and bone formation and prevent fractures and worsening bone disease.

"The current treatment for many bone diseases does two things: it stimulates osteoblasts, which help form bone, and it inhibits osteoclasts, which trigger bone resorption. That's a coupling problem, and it can lead to minimal benefit for patients," Cao said. "There is no drug designed to balance bone resorption with formation, and hopefully we can help change that."

Discovered many years ago, TGF beta-1 is one of the most abundant cytokines in bone. It has been identified in lung, liver, kidney and other organs that undergo remodeling as a natural part of the growth and aging process. Understanding the TGF beta-1 role in bone may shed light on many other diseases that have roots in biological imbalance, Cao said.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Army study improves ability to predict drinking water needs
2. Plant protein doorkeepers block invading microbes, study finds
3. Study finds role for parasites in evolution of sex
4. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
5. MS study offers theory for why repair of brains wiring fails
6. Oscar Pistorius: Previously confidential study results released on amputee sprinter
7. NSF provides $3.4 million to study climatically important Agulhas Current
8. Plant protein doorkeepers block invading microbes, study finds
9. ESHRE launches international study of polar body screening
10. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
11. Study finds DNA barcoding requires caution without closer examination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2017)... 23, 2017  Hunova, the first robotic gym for the rehabilitation and ... launched in Genoa, Italy . The first 30 robots ... the USA . The technology was developed and patented ... the IIT spin-off Movendo Technology thanks to a 10 million euro investment ... please click: ...
(Date:4/19/2017)... , April 19, 2017 ... its vendor landscape is marked by the presence of ... is however held by five major players - 3M ... these companies accounted for nearly 61% of the global ... leading companies in the global military biometrics market boast ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th year. ... San Francisco, CA. The Summit brings together current and former FDA office bearers, regulators, ... government officials from around the world to address key issues in device compliance, quality ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study ... in frozen and fresh in vitro fertilization (IVF) transfer cycles. The ... IVF success. , After comparing the results from the fresh and frozen transfer ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/9/2017)... Oct. 9, 2017  BioTech Holdings announced today ... which its ProCell stem cell therapy prevents limb ... The Company, demonstrated that treatment with ProCell resulted ... saved as compared to standard bone marrow stem ... resulted in reduction of therapeutic effect.  ...
Breaking Biology Technology: