Navigation Links
UAB study reveals bone coupling factor key to skeletal health
Date:7/8/2009

BIRMINGHAM, Ala. Researchers at the University of Alabama at Birmingham (UAB) have discovered a molecular coupling factor that helps bones grow and remodel themselves to stay strong, a finding that could lead to better bone-building therapies and new osteoporosis drugs, the researchers said

The coupling factor is a human protein called transforming growth factor beta-1, or TGF beta-1. Previously, scientists had searched for but missed the biological link between bone growth and bone remodeling a natural give-and-take system that is crucial to skeletal health. The discovery is reported online in the journal Nature Medicine.

"For the first time, we've identified TGF beta-1 is a coupling mechanism for bone resorption and bone formation," said Xu Cao, Ph.D., a professor in the UAB Department of Pathology and the study's senior author. "Osteoporosis, Paget's bone disease, Camurati-Engelmann disease, and many more, all involve a bone coupling disorder to some degree."

Previous research has hinted at but failed to explain the coupling role of TGF beta-1 in skeletal health. Bone remodeling occurs through resorption, the body's way of removing old and brittle bone to avoid breaks and skeletal disorders. Bone formation happens as skeletons grow and as the body works to counter bone resorption by laying down new bone.

Cao and his fellow researchers studied mice with Camurati-Engelmann disease, a genetic disorder that causes haphazard bone formation and poor skeletal health. They found the presence of TGF beta-1 in the mice could balance bone resorption and bone formation and prevent fractures and worsening bone disease.

"The current treatment for many bone diseases does two things: it stimulates osteoblasts, which help form bone, and it inhibits osteoclasts, which trigger bone resorption. That's a coupling problem, and it can lead to minimal benefit for patients," Cao said. "There is no drug designed to balance bone resorption with formation, and hopefully we can help change that."

Discovered many years ago, TGF beta-1 is one of the most abundant cytokines in bone. It has been identified in lung, liver, kidney and other organs that undergo remodeling as a natural part of the growth and aging process. Understanding the TGF beta-1 role in bone may shed light on many other diseases that have roots in biological imbalance, Cao said.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Army study improves ability to predict drinking water needs
2. Plant protein doorkeepers block invading microbes, study finds
3. Study finds role for parasites in evolution of sex
4. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
5. MS study offers theory for why repair of brains wiring fails
6. Oscar Pistorius: Previously confidential study results released on amputee sprinter
7. NSF provides $3.4 million to study climatically important Agulhas Current
8. Plant protein doorkeepers block invading microbes, study finds
9. ESHRE launches international study of polar body screening
10. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
11. Study finds DNA barcoding requires caution without closer examination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... , Apr. 11, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global eye tracking market to grow at a CAGR ... Global Eye Tracking Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... As the call ... healthcare industry stakeholders, the discussion surrounding the topic will continue at WEDI 2017- ... in Los Angeles, Calif. Hosted by the Workgroup for Electronic Data Interchange (WEDI), ...
(Date:4/25/2017)... April 25, 2017 Providence ... licensed its novel immune-modulating technology to an undisclosed global ... allergy. Tregitopes, pronounced TĀ·rejĀ·itopes, are a ... by EpiVax CEO Annie De Groot ... immunoglobulin G, an autoimmune disease therapy, Tregitopes are ...
(Date:4/24/2017)... , April 24, 2017  Dante Labs announced today ... only EUR 850 (ca. $900). While American individuals have been ... first time Europeans can access WGS below EUR 1,000. ... crucial to leveraging genetic information to make informed decisions about ... ...
(Date:4/21/2017)... ... ... The AMA is happy to announce that $48,000 in scholarships will be ... are created through funds donated by model aviation organizations and individuals, AMA members, and ... Scholarship Committee, which is made up of model aviation pilots and enthusiasts. The committee ...
Breaking Biology Technology: