Navigation Links
UAB study reveals bone coupling factor key to skeletal health
Date:7/8/2009

BIRMINGHAM, Ala. Researchers at the University of Alabama at Birmingham (UAB) have discovered a molecular coupling factor that helps bones grow and remodel themselves to stay strong, a finding that could lead to better bone-building therapies and new osteoporosis drugs, the researchers said

The coupling factor is a human protein called transforming growth factor beta-1, or TGF beta-1. Previously, scientists had searched for but missed the biological link between bone growth and bone remodeling a natural give-and-take system that is crucial to skeletal health. The discovery is reported online in the journal Nature Medicine.

"For the first time, we've identified TGF beta-1 is a coupling mechanism for bone resorption and bone formation," said Xu Cao, Ph.D., a professor in the UAB Department of Pathology and the study's senior author. "Osteoporosis, Paget's bone disease, Camurati-Engelmann disease, and many more, all involve a bone coupling disorder to some degree."

Previous research has hinted at but failed to explain the coupling role of TGF beta-1 in skeletal health. Bone remodeling occurs through resorption, the body's way of removing old and brittle bone to avoid breaks and skeletal disorders. Bone formation happens as skeletons grow and as the body works to counter bone resorption by laying down new bone.

Cao and his fellow researchers studied mice with Camurati-Engelmann disease, a genetic disorder that causes haphazard bone formation and poor skeletal health. They found the presence of TGF beta-1 in the mice could balance bone resorption and bone formation and prevent fractures and worsening bone disease.

"The current treatment for many bone diseases does two things: it stimulates osteoblasts, which help form bone, and it inhibits osteoclasts, which trigger bone resorption. That's a coupling problem, and it can lead to minimal benefit for patients," Cao said. "There is no drug designed to balance bone resorption with formation, and hopefully we can help change that."

Discovered many years ago, TGF beta-1 is one of the most abundant cytokines in bone. It has been identified in lung, liver, kidney and other organs that undergo remodeling as a natural part of the growth and aging process. Understanding the TGF beta-1 role in bone may shed light on many other diseases that have roots in biological imbalance, Cao said.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Army study improves ability to predict drinking water needs
2. Plant protein doorkeepers block invading microbes, study finds
3. Study finds role for parasites in evolution of sex
4. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
5. MS study offers theory for why repair of brains wiring fails
6. Oscar Pistorius: Previously confidential study results released on amputee sprinter
7. NSF provides $3.4 million to study climatically important Agulhas Current
8. Plant protein doorkeepers block invading microbes, study finds
9. ESHRE launches international study of polar body screening
10. Environmental cues control reproductive timing and longevity, University of Minnesota study shows
11. Study finds DNA barcoding requires caution without closer examination
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... Colo. , Jan. 5, 2017  SomaLogic ... the "Digital Life Alliance" established by iCarbonX, the ... 2015 to build a "Global Digital Health Ecosystem ... on a combination of individual,s biological, behavioral and ... the agreement between the companies, SomaLogic will provide ...
(Date:1/4/2017)... 4, 2017  CES 2017 – Valencell , ... today announced the launch of two new versions ... highly-accurate biometric sensor modules that incorporate the best ... and expertise. The two new designs include Benchmark ... hearables, and Benchmark BW2.0, a 2-LED version of ...
(Date:12/22/2016)... NEW YORK , December 22, 2016 ... global provider of secure solutions for the e-Government, Public Safety, HealthCare, ... a subsidiary of SuperCom, has been selected to implement and deploy ... county in Northern California , further expanding its ... ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... Calif. , Jan. 19, 2017  ArmaGen, ... Mathias Schmidt , Ph.D., as chief executive officer, ... of directors. Dr. Schmidt brings to ArmaGen more than ... the research and development of biotherapeutics and pharmaceuticals. ... executive with the diverse experience and skillset necessary ...
(Date:1/19/2017)... ... 2017 , ... FireflySci Inc. is a go-getter type of company that continues ... to two main factors. The first is the amazing customer service that the ... products all around the world. , 2016 was a tremendous sales year for FFS ...
(Date:1/19/2017)... PLAINVIEW, N.Y. , Jan. 18, 2017 ... pathology services, announces the formation of an Executive Committee ... 2017 and beyond. John Cucci , ... been promoted from Director of Business Development to ... in 2015, Mr. Cucci served in senior sales leadership ...
(Date:1/18/2017)... Jan. 18, 2017   Boston Biomedical , an ... to target cancer stemness pathways, will feature data from ... at the 2017 ASCO Gastrointestinal Cancers Symposium, held from ... Napabucasin is an orally-administered investigational agent ... i Cancer stem cells (CSCs) possess the property ...
Breaking Biology Technology: