Navigation Links
U researchers look to dogs to better understand intricacies of bone cancer
Date:7/28/2011

A new University of Minnesota discovery may help bone cancer patients fight their disease more effectively, according to new research published in the September issue of Bone.

Bone cancer typically affects children; the course and aggressiveness of the disease can vary from patient to patient and is very difficult to predict. Some patients respond remarkably well to conventional therapies. Their disease shows less aggressive behavior and they can survive for decades without recurrence. Others respond poorly to treatment or their disease comes back rapidly. Often, these patients survive less than five years.

Recently, a team led by Dr. Jaime Modiano, a College of Veterinary Medicine and Masonic Cancer center expert in comparative medicine, discovered a gene pattern that distinguishes the more severe form of bone cancer from a less aggressive form in dogs. Dogs are the only other species besides humans that develops this disease spontaneously with any frequency.

In fact, dogs are much more likely to develop bone cancer than humans, but according to Modiano who specializes in the relationship between animal and human disease human and canine forms of bone cancer are very similar and the gene pattern is an exact match. The discovery of this key differentiating signature may be beneficial in the treatment planning of human bone cancer patients.

"Our findings pave the way to develop laboratory tests that can predict the behavior of this tumor in dogs and children at the time of diagnosis," said Modiano. "This allows us to tailor individualized therapy to meet the patient's needs."

The downstream impact of the findings

University of Minnesota researchers hope to use their findings to develop practical and useful lab tests for humans and for companion animals that will help clinical care providers determine the type of cancer a patient faces, and how aggressive that cancer may be.

Then, depending on which type of cancer a patient has, clinicians could adjust interventions and treatment plans accordingly.

"Patients with less aggressive disease could be treated conservatively, reducing the side effects and the risks associated with treatment, while patients with more aggressive disease could be treated with more intense therapy," said Modiano.


'/>"/>

Contact: Kelly O'Connor
oconn246@umn.edu
612-624-5680
University of Minnesota
Source:Eurekalert

Related biology news :

1. NC State researchers get to root of parasite genome
2. Researchers find animal with ability to survive climate change
3. Researchers find an essential gene for forming ears of corn
4. Researchers note differences between people and animals on calorie restriction
5. Researchers study acoustic communication in deep-sea fish
6. Researchers discover that growing up too fast may mean dying young in honey bees
7. Researchers study how pistachios may improve heart health
8. UI researchers find potentially toxic substance present in Chicago air
9. Researchers develop new self-training gene prediction program for fungi
10. Case Western Reserve University researchers track Chernobyl fallout
11. Childrens National researchers develop novel anti-tumor vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... Inc. (NASDAQ: AWRE ), a leading supplier of ... quarter and year ended December 31, 2016. ... compared to $6.9 million in the same quarter last year. ... million compared to $2.6 million in the fourth quarter of ... $0.5 million, or $0.02 per diluted share, which compares to ...
(Date:2/8/2017)... -- Report Highlights The global biosurgery market ... in 2016 at a compound annual growth rate (CAGR) ... - An overview of the global market for biosurgery. ... 2015 and 2016, and projections of compound annual growth ... on the basis of product type, source, application, and ...
(Date:2/7/2017)... 2017 Ipsidy Inc. ( www.ipsidy.com ... IDGS], ("Ipsidy" or the "Company") a provider of secure, ... is pleased to announce the following changes as part ... January 31, 2017, Philip D. Beck was ... President.  An experienced payment industry professional and public company ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... ... 21, 2017 , ... Cancer diagnostics workflow solution provider Inspirata, ... team to lead the development and commercialization of its Cancer Information Data Trust ... and treatment of cancer. The CIDT addresses the need for curated and structured ...
(Date:2/21/2017)... ... February 21, 2017 , ... VetStem ... at its headquarters laboratory in Poway, California. Based upon 12 years of ... in-house personnel and consultants, VetStem constructed and validated a state-of-the-art GMP stem cell ...
(Date:2/21/2017)... returning partner of the Amgen Tour of California , has ... the men,s and women,s events for the next five editions of ... California will mark the start of a ... teams in the world racing from Northern to Southern ... Heart Disease TM Women,s Race empowered with SRAM will ...
(Date:2/21/2017)... --  Invitae Corporation (NYSE: NVTA), one of the ... of the company,s management team will present at the ... Monday, March 6, 2017 at approximately 4:00 p.m. Eastern ... . The live, listen-only webcast ... investors section of the company,s website at ir.invitae.com ...
Breaking Biology Technology: