Navigation Links
U of T-led study cracks universal RNA code, suggests a new cause for autism
Date:7/12/2013

The discovery cracks the "RNA control code," which dictates how RNA a family of molecules that mediates DNA expression moves genetic information from DNA to create proteins.

"For the first time, we understand the language of a code that is essential to gene processing," said Quaid Morris, a Professor in U of T's Donnelly Centre for Cellular and Biomolecular Research and the Banting and Best Department of Medical Research. "Many human diseases are due to defects in this code, so figuring out what it means is crucial to creating new treatments for many conditions."

The scientific journal Nature published the study results in its July 11, 2013 issue.

The researchers translated the code with a biochemical technique developed by a research scientist in Hughes' lab, Debashish Ray, and a student in Morris's lab, Hilal Kazan. The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing and movement, which are often altered in disease.

One protein they looked at may explain some of the symptoms in children with autism. The researchers found that RBFOX1, a protein often turned off in the brains of patients, ensures the activity of genes important for the function of nerve cells in the brain.

"This was a surprising finding, because we knew RBFOX1 controls gene expression, but had no idea it also stabilizes RNA," said Tim Hughes, a Professor in the Department of Molecular Genetics and the Donnelly Centre. "It's a good example of the predictive power of the RNA control code, which we think will really open up the field of gene regulation."

Hughes said the work also shows that the RNA control code may be easier to interpret than a similar control code in DNA. Researchers have been struggling for years to understand this DNA control code, but the new results suggest RNA control could offer a more fruitful area of inquiry, with aut
'/>"/>

Contact: Jim Oldfield
jim.oldfield@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Study finds surprising benefits about diary cow inflammation
3. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
4. Journal highlights Arctic sea ice study by UM professor
5. Innovative MIT study estimates extent to which air pollution in China shortens human lives
6. Temperature increases causing tropical forests to blossom, according to study
7. New study reveals important role of insulin in making breast milk
8. Study reveals ancient jigsaw puzzle of past supercontinent
9. Reproductive BioMedicine Online publishes study on assisted reproduction
10. Lifesaving HIV treatment could reach millions more people following landmark study
11. Low levels of toxic proteins linked to brain diseases, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... , August 12, 2015 As ... mobile payment innovation and advanced biometrics technology is accelerating ... way consumers rely on using their credit cards, the ... the future for payment services led by companies in ... ), :  Google, Inc. (NASDAQ: GOOG ), Apple ...
(Date:8/11/2015)... GOTHENBURG, Sweden , August 11, 2015 ... sensor FPC1155. Already received as well as expected revenues in 2015 ... included in FPC,s communicated revenue guidance of approximately 2,200 MSEK for ... is a prominent smartphone manufacturer ... ZUK selected FPC1 155 ...
(Date:8/6/2015)... Aug. 6, 2015  Today, U.S. Congressman ... Crossmatch ™ to learn firsthand how Silicon Valley ... Crossmatch is a world leader in multi-factor identity ... are helping federal agencies and commercial organizations achieve ... "The vast majority of network breaches ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Rep. Honda to Visit Crossmatch in Redwood City 2
... for Addiction and Mental Health (CAMH) has discovered ... retardation (MR) along with the eye defect retinitis ... gene that causes this disorder, CC2D2A. This ... biological processes involved in brain development, and may ...
... international team of researchers led by MIT has explained ... to slip past traditional safety screens and kill dozens ... The team, led by Professor Ram Sasisekharan of ... as oversulfated chondroitin sulfate (OSCS). The researchers present their ...
... deposits of volcanic glass in the western United States ... its present elevation 12 million years ago, roughly 8 ... The finding has implications not only for understanding the ... ancient global climates. "All the global climate models ...
Cached Biology News:New gene discovered for new form of intellectual disability 2MIT-led teams unravel heparin death mystery 2MIT-led teams unravel heparin death mystery 3Sierra Nevada rose to current height earlier than thought, say Stanford geologists 2Sierra Nevada rose to current height earlier than thought, say Stanford geologists 3Sierra Nevada rose to current height earlier than thought, say Stanford geologists 4
(Date:8/27/2015)... 2015 HUYA Bioscience International (HUYA) today announced the ... Society of HTLV-1, held this week at the University ... the Society is to promote research on HTLV-1 and ... technology and research related to these fields to advance ... is proud to support this prestigious conference," said ...
(Date:8/27/2015)... , Aug. 27, 2015 In response ... FedEx, UPS and The US Postal Service to ... classified as ,select agents, by the CDC, Marken ... handling these sensitive shipments. Marken uses ... regulations, trained and certified personnel to ensure the ...
(Date:8/26/2015)... 2015  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... solutions for the detection of foodborne pathogens, today announced ... Sidoti & Company Emerging Growth Conference on September 2 ... the New York Marriott Marquis. A ... the investor relations section of Roka Bioscience,s website at ...
(Date:8/26/2015)... 2015 Intrexon Corporation (NYSE: XON ), ... of its previously announced public offering of common stock, ... their option to purchase an additional 731,707 shares of ... per share.  The exercise of the underwriters, option brought ... by Intrexon to 5,609,756 shares and increased the total ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4
... 21 eTrinsic, a division of Simbionix USA,Corporation ... and,technology for training medical salespeople and professionals, today,announced ... Sales Executive for the,Midwest and Eastern Region. Glen ... in,Grayslake, Illinois. , Glen ...
... genetics (Nasdaq: DCGN ) announced today that it ... institution, pursuant to which NBI has purchased deCODE,s auction rate ... the agreement, deCODE has the call option to require NBI ... time prior to December 31, 2009. NBI has the put ...
... and Podcast for Healthcare ProfessionalsVOORHEES, N.J., Jan. 20 ... is critical for several reasons. The epidemiology of CDI ... and more severe disease. In addition, the epidemic ... of states across the United States and worldwide. ...
Cached Biology Technology:Glen C. Williams Joins eLearning Sales Team for Simbionix, Heading up Chicago Office 2deCODE Sells Auction Rate Securities 2deCODE Sells Auction Rate Securities 3Clostridium difficile Infection: Current Challenges and Controversies 2
... ExonHit can design custom microarrays to detect ... list. Proprietary algorithms are used to ... from high quality, spliced cDNAs aligned to ... in a custom SpliceArray is profiled with ...
... Splicing plays an important role in the ... and cell death. Splice variants have been ... inhibition of defined apoptotic pathways. With Apoptosis ... perform a classical expression profiling and at ...
... and signaling of the members of the ... by alternative splicing--which has important implications for ... perform a classical expression profiling and at ... spliced forms of the gene that are ...
... SPE Workstation is a modular, highly scalable, ... Utilizing 1ml or 3ml industry standard SPE ... 100 samples in less than two hours ... 10 cartridges, and up to 10 modules ...
Biology Products: