Navigation Links
U of T-led study cracks universal RNA code, suggests a new cause for autism
Date:7/12/2013

The discovery cracks the "RNA control code," which dictates how RNA a family of molecules that mediates DNA expression moves genetic information from DNA to create proteins.

"For the first time, we understand the language of a code that is essential to gene processing," said Quaid Morris, a Professor in U of T's Donnelly Centre for Cellular and Biomolecular Research and the Banting and Best Department of Medical Research. "Many human diseases are due to defects in this code, so figuring out what it means is crucial to creating new treatments for many conditions."

The scientific journal Nature published the study results in its July 11, 2013 issue.

The researchers translated the code with a biochemical technique developed by a research scientist in Hughes' lab, Debashish Ray, and a student in Morris's lab, Hilal Kazan. The team defined the meaning of "words" in RNA, allowing identification of patterns in RNA molecules that proteins use to control RNA processing and movement, which are often altered in disease.

One protein they looked at may explain some of the symptoms in children with autism. The researchers found that RBFOX1, a protein often turned off in the brains of patients, ensures the activity of genes important for the function of nerve cells in the brain.

"This was a surprising finding, because we knew RBFOX1 controls gene expression, but had no idea it also stabilizes RNA," said Tim Hughes, a Professor in the Department of Molecular Genetics and the Donnelly Centre. "It's a good example of the predictive power of the RNA control code, which we think will really open up the field of gene regulation."

Hughes said the work also shows that the RNA control code may be easier to interpret than a similar control code in DNA. Researchers have been struggling for years to understand this DNA control code, but the new results suggest RNA control could offer a more fruitful area of inquiry, with aut
'/>"/>

Contact: Jim Oldfield
jim.oldfield@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Vanderbilt-led team to develop microbrain to improve drug testing
2. Study finds surprising benefits about diary cow inflammation
3. Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests
4. Journal highlights Arctic sea ice study by UM professor
5. Innovative MIT study estimates extent to which air pollution in China shortens human lives
6. Temperature increases causing tropical forests to blossom, according to study
7. New study reveals important role of insulin in making breast milk
8. Study reveals ancient jigsaw puzzle of past supercontinent
9. Reproductive BioMedicine Online publishes study on assisted reproduction
10. Lifesaving HIV treatment could reach millions more people following landmark study
11. Low levels of toxic proteins linked to brain diseases, study suggests
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/lc9bnl/global_gesture ) has ... Market in Automotive Sector 2014-2018" report to their ... Recognition market in Automotive Sector to grow at a ... Gesture recognition is the ability of a device to ... Gesture recognition technology can be 2D-based or 3D-based. It ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... closely associated with the African savanna -- fierce lions, ... players when it comes to shaping the ecosystem. ... be the termite, say ecologists who,ve found that these ... Kenya via a network of uniformly distributed colonies. Termite ...
... study finds heterotrophic bacteria counts, in more than 70 ... specified by the United States Pharmacopeia (USP). Researchers ... 110th General Meeting of the American Society for Microbiology ... water a large number of urban Canadians are switching ...
... animals most closely associated with the African savanna -- ... relatively minor players when it comes to shaping the ... to be the termite, say ecologists who,ve found that ... central Kenya via a network of uniformly distributed colonies. ...
Cached Biology News:The star of Africa's savanna ecosystems may be the lowly termite 2The star of Africa's savanna ecosystems may be the lowly termite 3Study finds high level of bacteria in bottled water in Canada 2Lowly termite, not the lion or elephant, may be the star of Africa's savanna 2Lowly termite, not the lion or elephant, may be the star of Africa's savanna 3
(Date:4/1/2015)... , April 1, 2015  Adaptive Biotechnologies ... The Lancet Oncology showing that ... company,s next-generation sequencing-based minimal residual disease (MRD) detection ... MRD test) accurately identifies patients with diffuse large ... relapse after initial treatment, usually several months before ...
(Date:4/1/2015)... 01, 2015 Park Systems, ... selected to receive the prestigious “Best Analytic Instrumentation ... NX10 is the premium research-grade True Non-Contact AFM, ... linearity, closed-loop detector noise, and minimized thermal drift. ... n, which allows images with a single click, ...
(Date:4/1/2015)... /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: ... announce that Biohaven Pharmaceutical Holding Company Limited (Biohaven), ... an agreement with inVentiv Health for the operational ... lead compound (BHV-0223). Biohaven is ... stage neuroscience compounds targeting the glutamatergic system. Clinical ...
(Date:4/1/2015)... FORT LAUDERDALE, Fla. , April 1, 2015 /PRNewswire/ ... nothing at all about oral cancer (68 percent) and ... at their last dental check-up, according to findings from ... Inc. ("Vigilant"), a leading innovator and developer of ... of cancer. The online survey polled 1,050 ...
Breaking Biology Technology:Adaptive Biotechnologies' clonoSEQ Minimal Residual Disease Test Predicts Relapse in Diffuse Large B-Cell Lymphoma Patients by Sensitively Detecting Circulating Tumor DNA 2Adaptive Biotechnologies' clonoSEQ Minimal Residual Disease Test Predicts Relapse in Diffuse Large B-Cell Lymphoma Patients by Sensitively Detecting Circulating Tumor DNA 3Adaptive Biotechnologies' clonoSEQ Minimal Residual Disease Test Predicts Relapse in Diffuse Large B-Cell Lymphoma Patients by Sensitively Detecting Circulating Tumor DNA 4Adaptive Biotechnologies' clonoSEQ Minimal Residual Disease Test Predicts Relapse in Diffuse Large B-Cell Lymphoma Patients by Sensitively Detecting Circulating Tumor DNA 5Park Systems Awarded the New Economy Magazine “Best Analytic Instrumentation Company 2014” 2Portage's Biohaven Announces Agreement with inVentiv Health 2Portage's Biohaven Announces Agreement with inVentiv Health 3National Oral Cancer Awareness Survey Reveals Greater Need for Education and Screening Tools for Oral Cancer Among U.S. Adults 2National Oral Cancer Awareness Survey Reveals Greater Need for Education and Screening Tools for Oral Cancer Among U.S. Adults 3National Oral Cancer Awareness Survey Reveals Greater Need for Education and Screening Tools for Oral Cancer Among U.S. Adults 4
... of our nation,s long-term clean-energy future, but the technology ... Japan,s recent Fukushima disaster. Indeed, many nations have called ... are operating safely. In the United States, ... percent of the electricity from emission-free sources, including renewable ...
... Mediabrands, IPG Media Lab and Affectiva today announced, ... results of the first annual Neuromarketing Awards. Utilizing ... record and measure viewers, tacit, non-verbal response to ... features are established and are then measured and ...
... ,   The randomised, ... efficacy and safety of,the monoclonal antibody rituximab (RTX) ... that in patients with,severe AAV a single course ... period of 18 months proved to be as ...
Cached Biology Technology:Berkeley scientists pioneer nanoscale nuclear materials testing capability 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 2The IPG Media Lab and Affectiva Announce Winners of First Annual Neuromarketing Awards 3ERA-EDTA Congress 2011: Late Breaking Clinical Trials I 2
... (Intein Mediated Purification with an Affinity Chitin-binding ... engineered protein splicing elements (termed inteins) to ... column (1-4) (Figures 1 and 2). This ... systems by its ability to separate a ...
... Analysis Note: The kit contains all ... convenient determination of NADPH-cytochrome c reductase activity ... purified microsomes [endoplastic reticulum (ER)]. It has ... tissues such as liver, kidney, brain, spleen, ...
... provides the reagents to efficiently differentiate ... myotubes. By efficiently promoting myogenic differentiation, ... in studies examining myogenesis, transcription factor ... muscle cell replacement therapy. By providing ...
... CHEMICON's Cell Transformation Detection Assay is an ... is considered the most stringent assay for ... this assay, cells (pre-treated with carcinogens or ... in soft agar medium for 21-28 days. ...
Biology Products: