Navigation Links
U of T led research team uncovers evolutionary origins of prion disease gene
Date:9/28/2009

TORONTO, ON A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also known as "mad cow disease."

Diseased prion proteins are responsible for the fatal neurodegenerative Creutzfeldt-Jakob disease (CJD) in humans, and BSE, scrapie and chronic wasting disease (CWD) in livestock. Overall, this work holds promise for efforts to reveal the physiological function of members of the prion protein family and may provide insights into the origins and underlying constraints of the conformational changes associated with prion diseases. The study was published today, September 28, 2009, in the online journal PLoS ONE.

Principal investigator Gerold Schmitt-Ulms (Centre for Research in Neurodegenerative Diseases; Department of Laboratory Medicine and Pathobiology, U of T) and his graduate student Sepehr Ehsani teamed up with Holger Wille and Joel Watts (University of California, San Francisco) and David Westaway (University of Alberta) for this project. "The prion protein was discovered over twenty years ago and has been studied intensively. Nobody, however, knew its evolutionary origin and much confusion surrounds its physiological function," says Prof. Schmitt-Ulms. The team's analysis suggests that the prion gene is descended from the more ancient ZIP family of metal ion transporters. Members of the ZIP protein family are well known for their ability to transport zinc and other metals across cell membranes.

The U of T laboratory initially demonstrated the physical proximity of two metal ion transporters, ZIP6 and ZIP10, to mammalian prion proteins in living cells. As with the normal cellular prion protein, ZIP6 and ZIP10 exhibit widespread expression in biological tissues with high transcript levels in the brain. Schmitt-Ulms then made the startling discovery that prion and ZIP proteins contain extensive stretches of similar amino acid sequence. The researchers next documented that the respective segments within ZIP and prion proteins are computationally predicted to acquire a highly similar three-dimensional structure. Finally, the team uncovered multiple additional commonalities between ZIP and prion proteins which led them to conclude these molecules are evolutionarily related.

Most proteins do not act in isolation but partner with other proteins to exert their biological roles. The relationship between ZIP-family and prion proteins may thus provide a new angle from which to study the biology of the prion protein in health and disease. The level of shared characteristics between these protein families, in addition to the presence of prion protein genes in most chordate (i.e., backboned) species, place the split from the ZIP-like ancestor gene at the base of the chordate lineage.

Although no single evidence firmly established the phylogenetic relationship between ZIP and prion genes, Schmitt-Ulms is confident that the many corroborating pieces of evidence collected and, equally important, the absence of any conflicting observations, allow no other conclusion to be drawn.


'/>"/>

Contact: Jennifer Little
jennifer.little@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Related biology news :

1. UC nanotech researchers develop artificial pore
2. Researchers go underground to reveal 850 new species
3. Pitt researchers net $5 million from NIH to explore better ways to grow cells for regenerative medicine
4. Pitt researchers net $5 million from NIH to explore better ways to grow cells
5. NSF funds states first imaging system for UAB microscale research lab
6. US needs nearly $200 million more on climate-related health research
7. Malaria research wins Jake Baum a Young Tall Poppy award
8. Research needed to learn which DCIS patients may be candidates for less invasive therapy
9. Research network based at University of Toronto gets $5 million boost to speed up cancer detection
10. AFOSRs basic research may lead to revolutionary new devices
11. New research network at McMaster aims to build a better eye
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... MINNETONKA, Minn. , Jan. 18, 2017 /PRNewswire/ ... eClinical technology company that supports the entire spectrum ... 2016 has been another record-breaking year for the ... and market interest in MedNet,s eClinical products and ... to the tremendous marketplace success of ...
(Date:1/12/2017)... 2017  New research undertaken by Fit Small Business ... 1,000 participants were simply asked which office technology had they ... consider standard issue.  Insights on what will be ... from futurists and industry leaders including Penelope Trunk , ... Some of these findings included; ...
(Date:1/11/2017)... , Jan. 11, 2017  Michael Johnson, co-founder of Visikol Inc. ... Group, Inc., has been named to the elite "Forbes 30 Under ... one of 600 people in 20 fields nationwide to be recognized ... the 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers University. ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... , January 20, 2017 Stock-Callers.com ... conditions have influenced the most recent performances of select ... (NASDAQ: RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... TBPH ), and Sage Therapeutics Inc. (NASDAQ: ... by Grand View Research, global Biotech market size is expected to ...
(Date:1/20/2017)... YORK , January 20, 2017 ... Organization, cancer is one of leading causes of death ... 2012. Although the number of cancer related deaths increased ... 1990. Rising in incidence rate of various cancers continues ... to a research report by Global Market Insights, Inc. ...
(Date:1/19/2017)... Research and Markets has announced the addition of the ... Global Opportunity Analysis and Industry Forecast, 2014-2022" report to their ... Cancer ... reach $15,737 million by 2022 from $6,521 in 2015, growing at ... Omic technologies segment accounted for more than half of the revenue ...
(Date:1/19/2017)... Ky. and HOUSTON ... Inc. ("NX Prenatal") today announced the formation of ... together leading clinicians and industry veterans who enhance ... company as it accelerates development of its novel ... to provide medical, clinical and strategic guidance for ...
Breaking Biology Technology: