Navigation Links
U of T led research team uncovers evolutionary origins of prion disease gene
Date:9/28/2009

TORONTO, ON A University of Toronto-led team has uncovered the evolutionary ancestry of the prion gene, which may reveal new understandings of how the prion protein causes diseases such as bovine spongiform encephalopathy (BSE), also known as "mad cow disease."

Diseased prion proteins are responsible for the fatal neurodegenerative Creutzfeldt-Jakob disease (CJD) in humans, and BSE, scrapie and chronic wasting disease (CWD) in livestock. Overall, this work holds promise for efforts to reveal the physiological function of members of the prion protein family and may provide insights into the origins and underlying constraints of the conformational changes associated with prion diseases. The study was published today, September 28, 2009, in the online journal PLoS ONE.

Principal investigator Gerold Schmitt-Ulms (Centre for Research in Neurodegenerative Diseases; Department of Laboratory Medicine and Pathobiology, U of T) and his graduate student Sepehr Ehsani teamed up with Holger Wille and Joel Watts (University of California, San Francisco) and David Westaway (University of Alberta) for this project. "The prion protein was discovered over twenty years ago and has been studied intensively. Nobody, however, knew its evolutionary origin and much confusion surrounds its physiological function," says Prof. Schmitt-Ulms. The team's analysis suggests that the prion gene is descended from the more ancient ZIP family of metal ion transporters. Members of the ZIP protein family are well known for their ability to transport zinc and other metals across cell membranes.

The U of T laboratory initially demonstrated the physical proximity of two metal ion transporters, ZIP6 and ZIP10, to mammalian prion proteins in living cells. As with the normal cellular prion protein, ZIP6 and ZIP10 exhibit widespread expression in biological tissues with high transcript levels in the brain. Schmitt-Ulms then made the startling discovery that prion and ZIP
'/>"/>

Contact: Jennifer Little
jennifer.little@utoronto.ca
416-946-8423
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC nanotech researchers develop artificial pore
2. Researchers go underground to reveal 850 new species
3. Pitt researchers net $5 million from NIH to explore better ways to grow cells for regenerative medicine
4. Pitt researchers net $5 million from NIH to explore better ways to grow cells
5. NSF funds states first imaging system for UAB microscale research lab
6. US needs nearly $200 million more on climate-related health research
7. Malaria research wins Jake Baum a Young Tall Poppy award
8. Research needed to learn which DCIS patients may be candidates for less invasive therapy
9. Research network based at University of Toronto gets $5 million boost to speed up cancer detection
10. AFOSRs basic research may lead to revolutionary new devices
11. New research network at McMaster aims to build a better eye
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
(Date:7/11/2014)... de Janeiro, Brazil- In the brains of all ... that allows an electric or chemical signal to ... Chemical synapses, which are the most abundant type ... Synapse formation is crucial for learning, memory, perception ... inhibitory synapses critical for brain function. For ...
(Date:7/10/2014)... June 27, 2014  Pomerantz LLP has filed ... ("Provectus" or the "Company")(NYSE-MKT: PVCT) and certain of ... States District Court, Middle District of ... of a class consisting of all persons or ... between December 17, 2013 and May 22, 2014, ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3
... while engineered nanomaterials can be transferred up the ... celled organisms to higher multicelled ones, the amount ... evidence of the nanomaterials concentrating in the higher ... from the National Institute of Standards and Technology ...
... gyro . . . Airplanes, submarines and ... of inexpensive high-performance micro-mechanical gyroscopes for navigation and other ... developed by a team consisting of Panos Datskos, Slo ... is radically different than today,s gyroscopes, which are big ...
... summer where the tiger,s roar will meet birdsongs; where the voice ... advanced sonar systems; where the echoing din of the urban soundscape ... sounds -- and the scientific advances related to them -- will ... Monday June 30 through Friday July 4, 2008 at the Palais ...
Cached Biology News:Research measures movement of nanomaterials in simple model food chain 2Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 2Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2008 3
(Date:7/10/2014)... 2014 /PRNewswire-iReach/ -- Tute Genomics, the leader ... an agreement with Lineagen, Inc., to provide ... Dx PLUS.  Lineagen, focused on the ... currently offers FirstStep Dx PLUS, a ... by healthcare providers as a first-line genetic ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
(Date:7/10/2014)... research may help in the fight against terrorism with ... quantities of explosives with the use of light and ... Sensors and Actuators B: Chemical , the researchers describe ... in concentrations as low as 6.3 ppm (parts per ... few minutes. , "Traditionally explosives detection has involved looking ...
(Date:7/10/2014)... study published today in the journal PNAS (Proceedings ... that time of day and sleep deprivation have a ... crucial when looking at the best time of day ... disease, and for administering medicines effectively. , Researchers from ... Research, London, investigated the links between sleep deprivation, body ...
Breaking Biology Technology:Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9Detecting trace amounts of explosives with light 2Time of day crucial to accurately test for diseases, new research finds 2
... - Jason Smith acknowledges he's on a personal mission. The ... of the Peak Ridge Capital Group, wants to bridge the gap ... passion for investing in innovative Midwestern technology companies is one of ... in the morning and it is one of the first things ...
... Wis. - Broadlook Technologies , an Internet ... as the firm's chief operations officer. , ,Meier brings ... sectors, and he will be responsible for helping the ... programs. , ,"I believe in Greg, and he believed ...
... Madison, Wis. - A University of Wisconsin-Madison ... return in the nation, according to BusinessWeek 's latest ... class of 2006 paid $186,800 for their MBAs and started ... even in four and a half years, not counting lost ...
Cached Biology Technology:Investor links East Coast funds to Midwest tech 2Investor links East Coast funds to Midwest tech 3UW-Madison MBA program ranked among best for investment return 2
... reagent kit for determining the absolute count ... samples, mobilized peripheral blood samples, and leukapheresis ... total nucleated cell count and a total ... designed for use in the BD Procount ...
... Both compact and lightweight, the Moticam ... microscope through the eyepiece, eyetube, or trinocular ... easy to use Plug-and-Play Images 2.0ML software ... Image manipulation tools to maximize resolution for ...
... is an aqueous solution that contains a ... in a PBS buffer (phosphate buffered saline), ... does not contain a preservative. StabilCoat ... of dried protein components in immunoassays and ...
Mouse monoclonal antibody to PARK2 - Parkinson disease (autosomal recessive, juvenile) 2, parkin...
Biology Products: