Navigation Links
U of M study finds titan cells protect Cryptococcus

MINNEAPOLIS/ST. PAUL (MAY 28, 2012) Giant cells called "titan cells" protect the fungus Cryptococcus neoformans during infection, according to two University of Minnesota researchers. Kirsten Nielsen, Ph.D., an assistant professor in the department of microbiology, and recent Ph.D. recipient Laura Okagaki believe their discovery could help develop new ways to fight infections caused by Cryptococcus.

The findings will be published in the June issue of the journal Eukaryotic Cell. The study was funded by the National Institutes of Health and the University of Minnesota's Medical School.

Cryptococcus, a fungus frequently found in dust and dirt, is responsible for the deaths of more than 650,000 AIDS patients worldwide each year. It is also a potentially deadly concern among chemotherapy and organ transplant patients. Currently, Cryptococcus causes more annual deaths in sub-Saharan Africa than tuberculosis.

"While most healthy individuals are resistant to Cryptococcus infections, the fungus can cause deadly disease for those with already weak immune systems," said Dr. Nielsen.

When inhaled, Cryptococcus can cause an infection in the lungs. This infection can spread to the brain and result in meningitis, an often-deadly inflammation of the brain and spine.

Nielsen and Okagaki found that titan cells, or Cryptococcus cells ten to twenty times the size of a normal cell, are too large to be destroyed by the body's immune system.

Researchers also found the presence of titan cells can protect all Cryptococcus cells in the area, even the normal sized Cryptococcus cells.

"This tells us that titan cell formation is an important aspect of the interaction between the human/host and the organism that allows Cryptococcus to cause disease," said Nielsen. "This information will help us find new ways to treat Cryptococcus infections that are very difficult to treat with currently available drugs."


Contact: Miranda Taylor
University of Minnesota Academic Health Center

Related biology news :

1. Variations of a single gene can lead to too much or too little growth, study shows
2. Yale study concludes public apathy over climate change unrelated to science literacy
3. T cells hunt parasites like animal predators seek prey, a Penn Vet-Penn Physics study reveals
4. Study finds voter genetics may predict election outcomes
5. Army study: DNA vaccine and duck eggs protect against hantavirus disease
6. New HealthFocus® International Study Reveals Five Very Different Weight Management Consumers
7. New study shows how nanotechnology can help detect disease earlier
8. University of Leicester study finds low agreeableness linked to a preference for aggressive dogs
9. Squid ink from Jurassic period identical to modern squid ink, U.Va. study shows
10. Richer parasite diversity leads to healthier frogs, says University of Colorado study
11. Mercury in dolphins: Study compares toxin levels in captive and wild sea mammals
Post Your Comments:
(Date:10/29/2015)... , October 29, 2015 ... biometric authentication company focused on the growing mobile ... wallet announces that StackCommerce, a leading marketplace to ... featuring the Wocket® smart wallet on StackSocial for ... ) ("NXT-ID" or the "Company"), a biometric authentication ...
(Date:10/27/2015)... JOSE, Calif. , Oct. 27, 2015 Synaptics ... interface solutions, today announced that Google has adopted the ... of touch controller solutions to power its newest flagship ... 6P by Huawei. --> ... partners like Google to provide strategic collaboration in the ...
(Date:10/23/2015)... Research and Markets ( ) has ... Biometrics Market 2015-2019" report to their offering. ... global voice recognition biometrics market to grow at a ... --> --> The report, Global Voice ... an in-depth market analysis with inputs from industry experts. ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... DIEGO , Nov. 25, 2015 Orexigen® ... management will participate in a fireside chat discussion at ... New York . The discussion is scheduled ... .  A replay will be ... Media Contact:McDavid Stilwell  , Julie NormartVP, Corporate Communications ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
(Date:11/24/2015)... Halozyme Therapeutics, Inc. (NASDAQ: HALO ) will be ... York on Wednesday, December 2 at 9:30 a.m. ET/6:30 ... CEO, will provide a corporate overview. th Annual ... 1:00 p.m. ET/10:00 a.m. PT . Jim Mazzola , ... corporate overview. --> th Annual Oppenheimer Healthcare Conference ...
(Date:11/24/2015)... ... November 24, 2015 , ... International ... and one of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. ... 2015, where ISPE hosted the largest number of attendees in more than a ...
Breaking Biology Technology: