Navigation Links
U of M scientist gets 5-year, $10 million grant to direct innovative HIV research program
Date:4/18/2011

Reuben Harris, professor in the University of Minnesota's College of Biological Sciences, has been awarded a five-year, $10 million grant from the National Institutes of Health to direct a large-scale research effort to study a human antiviral protein with potential for treating HIV and other viral diseases.

The goal of the study will be to produce atomic resolution images of the protein (APOBEC3G) to better understand how it interacts with other proteins in human cells and with HIV to prevent the virus from attaching to and entering cells. This fundamental knowledge could lead to novel methods to alter this protein to make it more effective.

"You have to understand the nuts and bolts of the system before you can make alterations to interfere with the process," says Harris, an associate professor of biochemistry, molecular biology and biophysics. "I'm very optimistic that this will research will enable us to use this novel protein against HIV and other diseases."

The approach represents a paradigm shift in treating viral diseases. While most other strategies focus on the virus itself, this is among the first to focus on the host.

"Conventional methods focusing on HIV are susceptible to the inevitable emergence of drug resistant virus isolates, whereas drugs that target stable cellular proteins may be much less prone to this problem" says Harris.

Human cells produce a family of antiviral proteins (called APOBECs) that have the ability to destroy HIV. But HIV has evolved a way to overcome them using an accessory protein called Vif (virion infectivity factor) to degrade the APOBEC proteins and allow the virus to spread. In a previous study, researchers in Harris's lab showed how HIV binds to and destroys one of the APOBEC proteins. This suggests that a simple change in the chemical structure of the APOBEC proteins could convert the human proteins to more effective antiviral agents. A better understanding of the interact
'/>"/>

Contact: Jeff Falk
jfalk@umn.edu
612-626-1720
University of Minnesota
Source:Eurekalert

Page: 1 2

Related biology news :

1. NIH scientists identify gene that could hold the key to muscle repair
2. Gladstone scientists identify genes involved in embryonic heart development
3. Scripps Research scientists identify mechanism of long-term memory
4. Sackler Prize awarded to pioneering neuroscientist
5. Scientists identify a surprising new source of cancer stem cells
6. Scripps Research scientists uncover new DNA role in modifying gene function
7. Outsmarting cancer cells: SLU scientists learn how they spread
8. Scripps Research scientists find dual switch regulates fat formation
9. Scientists make bamboo tools to test theory explaining East Asias Stone Age tool scarcity
10. Young scientist at Virginia Commonwealth University wins Avanti prize
11. Scientists exploit ash tree pests chemical communication
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Chemical Society (ACS) Weekly PressPac from the Office of ... journals and Chemical & Engineering News ., Please ... as the source for this information.` PressPac Archive: ... New tests: Marijuana damages DNA and may ...
... New Zealand researchers have accelerated research into Multiple Sclerosis ... help to unravel the causes of MS and other ... published today in the prestigious journal Nature Genetics ... remained a mystery. This discovery reveals important new insights ...
... Supply Chain Council -- Global Organization -- Begins in Houston ... and academic member, University of Houston ... College of Technology , ... first permanent Regional Center of Excellence for the U.S. Gulf Region. ...
Cached Biology News:American Chemical Society weekly presspac -- June 10, 2009 2American Chemical Society weekly presspac -- June 10, 2009 3American Chemical Society weekly presspac -- June 10, 2009 4American Chemical Society weekly presspac -- June 10, 2009 5American Chemical Society weekly presspac -- June 10, 2009 6American Chemical Society weekly presspac -- June 10, 2009 7Aussie and Kiwi researchers make double MS genetic discovery 2University of Houston Site of Regional Center of Excellence 2
(Date:4/25/2015)... Join us for a webinar at 12 ... Times using the Transcreener® ADP Assay , Register ... increasingly being incorporated into lead development efforts because longer ... increased therapeutic window and reduced side effects. Though ... such surface plasmon resonance, conjugation of drugs can affect ...
(Date:4/24/2015)... Top student social innovators from the ... universities, including UCSD and SDSU, will pitch their impact ... national and nonprofit companies for an opportunity to win ... Social Innovation Challenge 2015 . , The 2015 Social ... addressing a diverse range of issues including poverty, education, ...
(Date:4/24/2015)... AZ (PRWEB) April 24, 2015 The ... State University (ASU) have entered into an agreement to ... A memorandum of agreement signed by the universities will ... student success and other services particularly, though not exclusively, ... “We have complementary strengths and a similar set of ...
(Date:4/24/2015)... 2015 Leading Regenerative Veterinary Medicine ... allogeneic stem-cell product development program and changes its’ ... corporate strategic direction. , “I am extremely pleased ... cell development program has been kicked into high ... facility and hiring of our new Director of ...
Breaking Biology Technology:BellBrook Labs Webinar: Analyzing Kinase Inhibitor Residence Times using the Transcreener® ADP Assay 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 25th Annual Social Innovation Challenge at University of San Diego - Students Pitch to Live Judging Panel to Take Home $75K 3South Dakota Mines, Arizona State University Pave Way for Cooperative Research 2Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2
... DIEGO , May 11 Biomatrica, ... a solution-centric partnership program established with industry and ... storage and management of nucleic acids.  The Biomatrica ... for the development, testing, validation and use of ...
... May 11 Trans World Alloys (TWA) , one of the ... of their state-of-the-art, 40,000 square foot service center at 249 East Gardena Blvd., ... , (Photo: ... For the past ...
... Rice University researchers report using ultracentrifugation (UCF) to create ... team, led by Rice Professor Junichiro Kono and graduate ... small but significant step toward the dream of an ... quantum nanowire. The other, led by Rice Professor ...
Cached Biology Technology:Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 2Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 3Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 4Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 5Biomatrica Launches New Partnership Program - Biomatrica Connect(TM) 6Titanium and Aluminum Distributor, Trans World Alloys Relocates to Its Newly Built, State-of-the-Art Headquarters in Gardena, California 2Nano parfait a treat for scientists 2Nano parfait a treat for scientists 3
Mouse monoclonal antibody raised against a full length recombinant LDB3. NCBI Entrez Gene ID = LDB3...
...
Mouse monoclonal antibody raised against a partial recombinant WDR5. NCBI Entrez Gene ID = WDR5...
... Polyclonal Antibody against Nonmuscle Myosin ... Purified Antibody (Stored in TBS + ... against the peptide SDVNETQPPQSE corresponding to ... chain isoform B (MHC-B) This antibody ...
Biology Products: