Navigation Links
U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
Date:3/5/2013

MINNEAPOLIS/ST. PAUL (March 5, 2013) Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

The research, which provides proof-of-principle for the feasibility of combining induced pluripotent stem cell technology and genetic correction to treat muscular dystrophy, could present a major step forward in autologous cell-based therapies for DMD and similar conditions and should pave the way for testing the approach in reprogrammed human pluripotent cells from muscular dystrophy patients.

The research is published in Nature Communications.

To achieve a meaningful, effective muscular dystrophy therapy in the mouse model, University of Minnesota researchers combined three groundbreaking technologies.

First, researchers reprogrammed skin cells into "pluripotent" cells cells capable of differentiation into any of the mature cell types within an organism. The researchers generated pluripotent cells from the skin of mice that carry mutations in the dystrophin and utrophin genes, causing the mice to develop a severe case of muscular dystrophy, much like the type seen in human DMD patients. This provided a platform that would mimic what would theoretically occur in human models.

The second technology employed is a genetic correction tool developed at the University of Minnesota: the Sleeping Beauty Transposon, a piece of DNA that can jump into the human genome, carrying useful genes with it. Lillehei Heart Institute researchers used Sleeping Beauty to deliver a gene called "micro-utrophin" to the pluripotent cells they were attempting to differentiate.

Much like dystrophin, human micro-utrophin can support muscle fiber strength and prevent muscle fiber injury throughout the body. But one key difference between the two is in
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
2. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
3. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
4. 3 Johns Hopkins researchers recognized for medical inventions
5. University of Alberta researchers bake a better loaf of bread
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Brown University researchers build robotic bat wing
8. Researchers say sunlight yields more efficient carbon dioxide to methanol model
9. Researchers decipher modus operandi of potential Alzheimers drug
10. Stanford researchers develop tool for reading the minds of mice
11. Researchers in Manchester find genetic key to preventing spine tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
(Date:4/27/2015)... Conn. , Apr. 27, 2015 NXT-ID, ... a biometric authentication company focused on the growing mobile ... commence shipping to pre-order customers the first week of ... through the month of May. ... a significant milestone for the company as Wocket® enters ...
(Date:4/27/2015)... 27, 2015 Profile Solutions, Inc. (OTC: PSIQ), ... systems is pleased to announce that Dr Gerry ... and member of its scientific advisory board. ... a thought leader in technology-enhanced learning models. He was ... has published studies and books focused on online student ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... , LAS VEGAS , April 27 In its third ... open to a more inclusive pool of contestants and takes place three times ... Championship) invites any company with tea inventory in North America to ... harvests of hot tea, as well as iced tea. , ...
... April 27 From international jetsetter to model to entrepreneur, ... resume as she unveils her debut collection for QVC. The Slovenian beauty is scheduled ... PM (ET) to debut the Melania™ Timepieces & Fashion Jewelry line ... , , ...
... with a volume equivalent to 40 Amazon Rivers has been ... in the Indian Ocean sector of the Southern Ocean, 4200 ... Nature Geoscience , the researchers described the current more ... important pathway in a global network of ocean currents that ...
Cached Biology News:World Tea Expo Throws Open Door to Tea Championship 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 3Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 4Massive Southern Ocean current discovered 2
(Date:5/1/2015)... , May 1, 2015  Northwest Biotherapeutics (NASDAQ: ... developing DCVax® personalized immune therapies for solid tumor cancers, ... $28.5 million second tranche of a $40 million investment ... Woodford first invested $25 million in NW Bio ... entered into an agreement with the Company for a ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 OncoTAb, ... (UNC Charlotte) spin-out company, announced that Pinku Mukherjee, Ph.D. ... the UNC Board of Governors’ highest faculty honor. Mukherjee ... humanity’s welfare , for her innovative research and development ... Gardner Award represents a crowning moment in my scientific ...
(Date:5/1/2015)... 2015 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ), ... it has priced an underwritten registered offering of 3,900,000 ... $9.00 per share, and granted the underwriters in the ... additional 585,000 shares of its common stock. The gross ... is expected to close on May 6, 2015, subject ...
(Date:5/1/2015)... 2015 Pfenex Inc. (NYSE MKT: PFNX), ... of biosimilar therapeutics including high value and difficult ... quarter 2015 financial results will be released on ... market. At 8:30 am Eastern Time, Pfenex management will ... results and provide a business update. A press release ...
Breaking Biology Technology:NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 2BioAmber Inc. Announces Pricing Of $35.1 Million Registered Offering 3Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2
... Wash.The world,s biggest Roman candle has got nothing on ... in the Earth or on a giant planet, Washington ... capable of storing vast amounts of energy. "If you ... of energy storage outside of nuclear energy," says Choong-Shik ...
... engineering school in Grenoble, France, and Virginia Tech is ... The students, work will help gene synthesis companies and ... DNA as harmful agents for bioterrorism. Synthetic biology ... production, agriculture, and other areas. For a few thousand ...
... Nanoscience has garnered billions of dollars of funding and ... Revolution. But, for such a richly anticipated field, ... us from odor-eating socks to cosmetics and medications ... with visions of nanotechnology as cornucopia or Armageddon. ...
Cached Biology Technology:iGEM team helps prevent rogue use of synthetic biology 2New resource examines questions about the role of nanoscience 2
A compact, high-speed single tube reader unit designed for benchtop 2D barcode reading. The unit can be used with all of ABgene's 2D barcoded tubes, including the 2ml CryoCode tube....
PTFE/red rubber septum silver aluminum seal ,11 mm seal diam. ...
... stops PCR carry-over contamination, which prevents ... PCR products from previous PCR amplifications ... which improves amplification ,Optimized for use ... GeneAmp instrument systems , The GeneAmp ...
... hydrolytic enzyme that catalyzes the conversion,of ... maltose, maltotriose and,dextrins. The level of ... human,body are of clinical importance,1-3 while ... for industry.4, The EnzChek Amylase Assay ...
Biology Products: