Navigation Links
U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
Date:3/5/2013

MINNEAPOLIS/ST. PAUL (March 5, 2013) Researchers at the University of Minnesota's Lillehei Heart Institute have combined genetic repair with cellular reprogramming to generate stem cells capable of muscle regeneration in a mouse model for Duchenne Muscular Dystrophy (DMD).

The research, which provides proof-of-principle for the feasibility of combining induced pluripotent stem cell technology and genetic correction to treat muscular dystrophy, could present a major step forward in autologous cell-based therapies for DMD and similar conditions and should pave the way for testing the approach in reprogrammed human pluripotent cells from muscular dystrophy patients.

The research is published in Nature Communications.

To achieve a meaningful, effective muscular dystrophy therapy in the mouse model, University of Minnesota researchers combined three groundbreaking technologies.

First, researchers reprogrammed skin cells into "pluripotent" cells cells capable of differentiation into any of the mature cell types within an organism. The researchers generated pluripotent cells from the skin of mice that carry mutations in the dystrophin and utrophin genes, causing the mice to develop a severe case of muscular dystrophy, much like the type seen in human DMD patients. This provided a platform that would mimic what would theoretically occur in human models.

The second technology employed is a genetic correction tool developed at the University of Minnesota: the Sleeping Beauty Transposon, a piece of DNA that can jump into the human genome, carrying useful genes with it. Lillehei Heart Institute researchers used Sleeping Beauty to deliver a gene called "micro-utrophin" to the pluripotent cells they were attempting to differentiate.

Much like dystrophin, human micro-utrophin can support muscle fiber strength and prevent muscle fiber injury throughout the body. But one key difference between the two is in
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
2. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
3. U of M researchers identify genetic variation behind acute myeloid leukemia treatment success
4. 3 Johns Hopkins researchers recognized for medical inventions
5. University of Alberta researchers bake a better loaf of bread
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Brown University researchers build robotic bat wing
8. Researchers say sunlight yields more efficient carbon dioxide to methanol model
9. Researchers decipher modus operandi of potential Alzheimers drug
10. Stanford researchers develop tool for reading the minds of mice
11. Researchers in Manchester find genetic key to preventing spine tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... and TELTOW, Germany , ... 2015 Siggraph Conference, SensoMotoric Instruments (SMI) shows ... reality , based on Epson,s Moverio BT-200 ... tracking platform. With this new solution, unprecedented quality and ... hands-free interaction with context-sensitive displays. For the first time, ...
(Date:8/5/2015)... ALBANY, New York , August 5, 2015 /PRNewswire/ ... new market report titled "Facial Recognition Market - Global ... - 2022", the global market for facial recognition is ... market is driven by increased demand for surveillance systems ... to the rising number of crimes and terrorist activities ...
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 2Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 3Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 4Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 5Facial Recognition Market Expected to Reach US$ 2.67 Bn by 2022, at a CAGR of 9.5% From 2015 - 2022: Transparency Market Research 6AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... The National Institute of Neurological Disorders and Stroke (NINDS), a ... new sites as part of the Morris K. Udall Centers ... will provide a five-year investment totaling more than $16 million ... Medical Research in Manhasset, N.Y. NINDS Director ...
... been adjusting to strict new government standards that limit ... to the cover story of the current issue of ... impurities are "genotoxic," capable of damaging the DNA in ... internationally accepted regulations long have limited the levels of ...
... for the world,s plants, conducted by the Royal Botanic Gardens, ... International Union for the Conservation of Nature (IUCN), has revealed ... one in five of the world,s plant species threatened with ... and is the first time that the true extent of ...
Cached Biology News:NINDS awards new Udall Centers for Parkinson's Disease Research 2NINDS awards new Udall Centers for Parkinson's Disease Research 3New study shows over one-fifth of the world's plants are under threat of extinction 2New study shows over one-fifth of the world's plants are under threat of extinction 3New study shows over one-fifth of the world's plants are under threat of extinction 4
(Date:9/1/2015)... ... September 01, 2015 , ... Industry leader iLab Solutions ... In this newly-created position, Gibbs will lead iLab’s business operations in the region, ... tools. This entails not only introducing iLab to potential partners but support and ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... of California Los Angeles, Boston University School of Medicine, Frederick National Laboratory for ... One, the world’s first multidisciplinary Open Access journal. , Christopher Ryan PhD, ...
(Date:9/1/2015)... 1, 2015 Shire plc (LSE: SHP, ... Mathew to its Board of Directors as a Non-Executive ... Compliance & Risk Committee of the Shire Board. Both appointments ... Sara previously served as Chairman, President and Chief Executive Officer ... During her 12-year tenure at D&B, she helped drive the ...
(Date:8/31/2015)... , Aug. 31, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... $5.7 million. The orders are for air emission abatement projects in ... note is a large order for a municipality in the ... be replacing a competitor,s system that failed to meet the ... engineered solutions," said Derek S. Webb , President and ...
Breaking Biology Technology:iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 2Synedgen’s Director for Pharmaceutical Manufacturing Publishes New Research 3Shire Appoints Sara Mathew to Board of Directors 2
... MailFoundry , a provider of anti-spam appliances and solutions, has ... spam tactics known as botnet e-mail harvesting ... chief executive said the new RedListing anti-spam layer, produced for ... false positives and realtime detection capabilities. , ,David C. Troup, ...
... - Lance Armstrong is a unique phenomenon. He's ... is in a league by himself. Or is he? , ,As ... A recent National Center for Health Statistics report released ... cancer deaths for the second year in a row. , ,Cancer ...
... The Foundation for Taxpayer and Consumer Rights , ... licensing requirements on human embryonic stem cell patents held by ... in the right direction, but don't go far enough to ... the Public Patent Foundation , which have mounted a ...
Cached Biology Technology:Lance Armstrong and the future of cancer care 2Lance Armstrong and the future of cancer care 3Lance Armstrong and the future of cancer care 4Lance Armstrong and the future of cancer care 5WARF will ease stem cell licensing restrictions 2
Vitronectin Immunogen: Purified, full length, native human protein. Storage: -20 C, Avoid Freeze/Thaw Cycles...
... Guava has made microcapillary flow cytometry accessible ... experts alike will appreciate the latest addition ... Pluseasy to use, surprising affordable, and very ... system includes such features as absolute cell ...
...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Biology Products: