Navigation Links
U of M researchers identify new functions for autoimmune disease 'risk' gene
Date:7/19/2013

MINNEAPOLIS/ST. PAUL (July 19, 2013) Researchers at the University of Minnesota have identified infection-fighting and inflammation-suppressing functions for a gene associated with human autoimmune disease.

The discovery, centered on a gene known as PTPN22, could set into motion new treatment approaches for autoimmune diseases like lupus, rheumatoid arthritis and type 1 diabetes. The key to these advances may lie with a better understanding of how a variant of PTPN22, known as a "risk variant," impacts autoimmune disease development and the behavior of myeloid cells that act as the body's "first responders."

The study appears in the journal Immunity.

In launching their latest research project, University of Minnesota Center for Immunology researchers set out to determine how PTPN22 could regulate immune system function in health and disease.

"Almost a decade ago, researchers at the University of Minnesota and other institutions discovered that people carrying a variant form of the PTPN22 gene bear an increased risk of becoming sick with certain autoimmune diseases. However, we have lacked a deep understanding how the variant creates that increased risk," said Erik J. Peterson, M.D., one of the study's lead authors and a University of Minnesota Medical School associate professor in the Division of Rheumatic and Autoimmune Diseases. "We wanted to understand the molecular basis for PTPN22 association with disease."

Much of the work carried out in the latest study took place in Peterson's laboratory, which utilizes genetic, biochemical, and primary human sample-based approaches to investigate how "risk" genes predispose to development of autoimmune disease.

According to the study's authors, previous research showed that PTPN22 works in immune cells, but few studies had specifically examined PTPN22's function in infection-fighting cells called myeloid cells.

"Myeloid cells are among the body
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Solving DNA puzzles is overwhelming computer systems, researchers warn
2. Antiviral enzyme contributes to several forms of cancer, University of Minnesota researchers say
3. Carnegie Mellon researchers develop artificial cells to study molecular crowding and gene expression
4. Researchers perform DNA computation in living cells
5. Memorial Sloan-Kettering researchers develop new method for tracking cell signaling
6. Researchers create method to rapidly identify specific strains of illness
7. Stanford researchers say peak oil concerns should ease
8. MU researchers find condition in dogs that may help further research into human disease
9. OU researchers receive OCAST awards for health research projects
10. UCLA researchers find new clue to cause of human narcolepsy
11. Researchers discover new way to block inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
(Date:7/2/2015)... DUBLIN , June 25, 2015 ... the addition of the "Next Generation Biometrics Market ... to 2020" report to their offering. ... $24.4 Billion by 2020, at a CAGR of 17.9% ... is the leading application for the market. Safran ...
(Date:7/2/2015)... -- Fingerprint Cards has received an order for ... the distributor World Peace Industrial Group (WPI), part of WPG ... Asia . Deliveries are planned to take place during ... smartphone manufacturers in Asia . The order ... guidance of approximately 2,200 MSEK for 2015. Jörgen ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2
... traits persist in a population because predators detect common forms ... journal BMC Ecology found that birds will target ... behavior in response to alterations in the ratio of a ... Tennessee, worked with Kim Shook and Reuben Izally to study ...
... NetAnchor Secures Valuable Assets and Systems in Critical ... and TransportationIRVINE, Calif., May 11 ... solutions, today announced the availability of NetAnchor(TM), a ... systems and information particularly in industries designated as ...
... combined with the latest sequencing methods, researchers have uncovered ... millepora ). Their study, described in the open access ... database of genes and genetic markers currently available for ... the University of Texas at Austin and Indiana University, ...
Cached Biology News:Uniloc Unveils Industry-First Authentication Technology for Comprehensive Protection of Critical Infrastructure 2New genomic technique uncovers coral transcriptome 2
(Date:7/2/2015)... GLEN ELLYN, Ill. , July 2, 2015 /PRNewswire-USNewswire/ ... and Colton Eakins are gaining invaluable real-world ... Institute of Technology this summer. The students ... Dr. Jeff Wereszczynski,s research group at IIT. ... Professors Dr. Tom Carter , Physics; Dr. ...
(Date:7/2/2015)... Md. , July 2, 2015  Spherix Incorporated ... to the fostering and monetization of intellectual property, today ... of Spherix Incorporated v. Verizon Services Corp. et ... District Court for the Eastern District of ... on July 1, 2015 interpreting certain key claims in ...
(Date:7/2/2015)... GLASGOW, Scotland , July 2, 2015 ...   Bio-tech procurement company Amici Procurement has ... IOM) to help it move to Office 365. ... Procurement provides small to medium-sized companies in the ... with all aspects of the purchasing cycle to help ...
(Date:7/2/2015)... ... July 02, 2015 , ... Sleepless nights will become obsolete as ... sleep, launched its Indiegogo campaign on June 23. Sound sleepers and the sleep deprived ... it effortless to use, while the integration of the Bluetooth speaker, alarm clock and ...
Breaking Biology Technology:COD Students Participate in Prestigious Summer Internships 2Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3Biotech Procurement Company Moves to Office 365 with iomart 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3
... announces the publication of their membrane protein structure market ... & Techniques Used in the Study of Membrane Protein ... structural biology product suppliers with critical insights as to ... for rapid growth. Recent technological advancements and the introduction ...
... SeraCare Life Sciences, Inc. (Nasdaq: SRLS ), ... services to facilitate the discovery, development and production of ... entered into a loan agreement that provides senior secured ... with Middlesex Savings Bank and Commerce Bank and Trust ...
... Orexigen ® Therapeutics, Inc. (Nasdaq: ... treatment of obesity, today announced that the Company ... Conference. The details are as follows: JP Morgan ...  Westin St. Francis Hotel, San Francisco, CaliforniaSpeaker:  Mike ...
Cached Biology Technology:BioInformatics, LLC New Market Report - Membrane Protein Structure 2SeraCare Life Sciences Secures $20 Million Credit Facilities 2SeraCare Life Sciences Secures $20 Million Credit Facilities 3
... iEMS Incubator/Shaker HT is designed ... iEMS Incubator/Shaker HT is ideal ... hybridization and primer extension assays. ... available as a one-cabinet model, ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
... A modified nucleotide structure called ... 5?-end of most naturally-occurring eukaryotic mRNAs ... Cap Analog for a portion of ... vitro transcription reaction results in the ...
Biology Products: