Navigation Links
U of M researchers identify gene linked to common ailment in labrador retrievers

Researchers at the University of Minnesota College of Veterinary Medicine have identified a gene in Labrador retriever dogs highly associated with the syndrome of exercise-induced collapse (EIC). After intense hunting or retrieving exercise, activities these dogs are trained to perform, affected Labradors start to lose control of their hind limbs. In most cases, their legs get wobbly and the limbs give out, and in rare cases the dogs may die. Labradors are the most common dog breed in the world and an estimated 3-5 percent of Labradors have this condition. The research is published in the journal Nature Genetics.

The research team identified a mutant form of the dynamin 1 gene as highly associated with EIC. The dynamin 1 protein normally functions to maintain proper chemical communication between adjacent nerves, also known as synaptic transmission. However, the mutated form of the dynamin protein appears to have diminished function, interrupting synaptic transmission during intense exercise, and causing the muscle-controlling nerves to not fire when directed to do so.

"This is very exciting because it is the first naturally occurring mutation of this gene identified in any mammal," said James Mickelson, Ph.D, professor of veterinary sciences at the University of Minnesota and co-principal investigator on the study. "Its discovery could offer insight into normal as well as abnormal neurobiology in both animals and humans."

Researchers also determined that up to 30 percent of Labrador retrievers are carriers of the mutation, and they developed a genetic test to indicate whether dogs have the normal or mutated forms of the gene.

"The test can not only help confirm the diagnosis, but it can also help dog breeders ensure that no dogs inherit two copies of the mutated gene," said Edward "Ned" Patterson, D.V.M, Ph.D., assistant professor of veterinary medicine at the University of Minnesota and co-principal investigator of the study.

Owners can have their dogs tested through their veterinarian by submitting a blood sample to the University of Minnesota Veterinary Diagnostic Laboratory. Breeds such as Chesapeake Bay and curly-coated retrievers, which are closely related to Labradors, have also been found to have the dynamin 1 mutation. The research team is now determining what other breeds might be involved and more precisely defining the specific alteration in dynamin function.


Contact: Molly Portz
University of Minnesota

Related biology news :

1. Friendly bacteria protect against type 1 diabetes, Yale researchers find
2. Using novel tool, UD researchers dig through cell trash and find treasure
3. More than skin deep: Theres no such thing as a safe suntan, researchers warn
4. Flatworm helps researchers study stem cells and cancer
5. Giant grass offers clues to growing corn in cooler climes, researchers report
6. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
7. 1-hit event provides new opportunity for colon cancer prevention, say Fox Chase researchers
8. Researchers identify cancer-causing gene in many colon cancers
9. Curbing coal emissions alone might avert climate danger, say researchers
10. Researchers develop nano-sized cargo ships to target and destroy tumors
11. Gap junction protein vital to successful pregnancy, researchers find
Post Your Comments:
(Date:10/27/2015)... , Oct. 27, 2015 Synaptics Inc. (NASDAQ: ... today announced that Google has adopted the Synaptics ® ... controller solutions to power its newest flagship smartphones, the ... Huawei. --> --> ... Google to provide strategic collaboration in the joint development ...
(Date:10/26/2015)... , Oct. 26, 2015  Delta ID Inc., a ... to mobile and PC devices, announced its ActiveIRIS® technology ... arrows NX F-02H launched by NTT DOCOMO, INC in ... is the second smartphone to include iris recognition technology, ... ARROWS NX F-04G in May 2015, world,s first smartphone ...
(Date:10/22/2015)... (NASDAQ: AWRE ), a leading supplier of biometrics software and ... 30, 2015.  --> --> ... decrease of 33% compared to $6.0 million in the same quarter ... $2.2 million, or $0.10 per diluted share, which compared to $2.6 ... year ago.  --> --> ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... ... The Academy of Model Aeronautics (AMA), led by its Executive Council, has ... Prix, to represent the First–Person View (FPV) racing community. , FPV racing has exploded ... of racing and several new model aviation pilots have joined the community because of ...
(Date:11/24/2015)... Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced that ... 2015 at 11:00 a.m. Israel time, at the ... Yigal Allon Street, 36 th Floor, Tel Aviv, Israel ... Paneth and Izhak Tamir to the Board of Directors; ... external directors; , approval of an amendment to certain terms of ...
(Date:11/24/2015)... Switzerland (PRWEB) , ... November 24, 2015 , ... ... plant and the environment are paramount. Insertion points for in-line sensors can represent ... has developed the InTrac 781/784 series of retractable sensor housings , which ...
(Date:11/24/2015)... LAVAL, QC , Nov. 24, 2015 /CNW Telbec/ - ... the "Corporation") announced today that Mr. Pierre Laurin , ... a corporate presentation at the upcoming Piper Jaffray 27 th ... York Palace Hotel, on December 1-2, 2015. ... be available for one-on-one meetings throughout the day. The presentation ...
Breaking Biology Technology: