Navigation Links
U of M researchers identify 2 FDA approved drugs that may fight HIV
Date:8/20/2010

Researchers at the University of Minnesota Academic Health Center have identified two drugs that, when combined, may serve as an effective treatment for HIV.

The two drugs, decitabine and gemcitabine both FDA approved and currently used in pre-cancer and cancer therapy were found to eliminate HIV infection in the mouse model by causing the virus to mutate itself to death an outcome researchers dubbed "lethal mutagenesis."

This is a landmark finding in HIV research because it is the first time this novel approach has been used to attack the deadly virus without causing toxic side effects. Because decitabine and gemcitabine are already FDA approved, researchers believe that if their research is effective in large animal models, it will be much easier to expedite the development of the drugs for human use.

The study is a collaboration between molecular virologists Louis Mansky, Ph.D., and Christine Clouser, Ph.D., of the Institute for Molecular Virology and School of Dentistry, as well as medicinal chemist Steven Patterson, Ph.D., from the Center for Drug Design. The findings were recently published online in the Journal of Virology.

"The findings provide hope that such an approach will someday help the 33 million people worldwide who currently live with HIV," Mansky said.

Lethal mutagenesis

HIV mutates and evolves quickly. Rather than inhibiting virus growth and replication like current HIV drugs, this new drug combination forces the virus to do just the opposite evolve beyond control, to the point of extinction.

"HIV's ability to mutate makes it difficult to target and treat," Mansky said. "We wanted to take advantage of this behavior by stimulating HIV's mutation rate, essentially using the virus as a weapon against itself."

Drug repositioning

One way to decrease cost and expedite the development of novel drugs is by the use of drug repositioning, the process of taki
'/>"/>

Contact: Sarah Hamman
hamma041@umn.edu
612-624-7403
University of Minnesota
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers advance understanding of enzyme that regulates DNA
2. Juelich researchers take a look inside molecules
3. Researchers: Cures to diseases may live in our guts
4. Researchers discover how the storehouses of plant cells are formed
5. Mount Sinai researchers discover new mechanism behind cellular energy conversion
6. ISU researchers discover cause of immune system avoidance of certain pathogens
7. Researchers develop MRSA-killing paint
8. Researchers discover genetic link between immune system, Parkinsons disease
9. Ben-Gurion U. researchers receive US-AID MERC grant for water project with the Palestinian authority
10. Illinois researchers use pyrosequencing to study canine intestinal bacteria
11. Researchers find that one type of stem cell creates a niche for another type in bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... of Medicine have pinpointed a mechanism in part of the ... blood, linking it to both type 1 and type 2 ... of Proceedings of the National Academies of Sciences . ... located in a part of the hypothalamus known as the ... that control glucose levels in the blood," said lead author ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
(Date:7/28/2014)... has identified areas of the Earth that are high ... , Europe is particularly vulnerable, as it has the ... cent, of any continent in ,refugia, areas of ... conditions remain relatively constant during times of great environmental ... mostly in Scandinavia and Scotland. , The biggest ...
Breaking Biology News(10 mins):Glucose 'control switch' in the brain key to both types of diabetes 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3Study finds Europe's habitat and wildlife is vulnerable to climate change 2
... TORONTO, ON A team of University of Toronto chemists ... quantum biology, observing quantum mechanics at work in photosynthesis in ... speculation that nature may be using quantum mechanical practices," says ... published this week in Nature . "Our latest ...
... that glaciers in the Himalayan mountains are thinning is ... examine and quantify the causes. Lawrence Berkeley National Laboratory ... of the most commonly blamed culpritgreenhouse gases, such as ... be causing the melting. Menon and her collaborators found ...
... For Immediate Release A team of scientists at ... on novel binding sites for an enzyme used by the ... discovery lays the foundation for the development of a new ... strains of the disease, and slow the evolution of drug ...
Cached Biology News:Scientists find quantum mechanics at work in photosynthesis 2Black carbon a significant factor in melting of Himalayan glaciers 2Black carbon a significant factor in melting of Himalayan glaciers 3Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug 2Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug 3Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug 4Scripps Research scientists find two compounds that lay the foundation for a new class of AIDS drug 5
(Date:7/29/2014)... The first product launch from start-up ... to robotics. What sets Droidles completely apart from other ... allows them to communicate, share code with each other ... , “The invention is the system,” said Hurley Research ... life of their own, both physically and on the ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 The prestigious ... of Congress was recently awarded to Juliana Hillis and ... MA, for their project, “From an Egg, Everything: America’s ... 3,000 final entries for the National History Day program ... 300 historians and educators in Washington, D.C. , The ...
(Date:7/29/2014)... July 29, 2014 White papers ... and cloud based eClinical technologies, have been published by ... These follow a long line of white papers by ... including Life Science Leader, Pharmaceutical Online, and OpenHealthNews. , ... a paper by CTO Marc Desgrousilliers, 'The Five ...
(Date:7/29/2014)... July 29, 2014 ... (LBS) zur Erfassung biologischer Daten in Verbindung ... und patentiert. Das LBS nimmt gleichzeitig mehrere ... des Patienten und sucht erhöhte biologische Aktivitäten ... Potenzial, die Entdeckung und Entwicklung neuer Medikamente ...
Breaking Biology Technology:Droidles, the Social Network of Robots and Open Source Platform for the Internet of Things, Launches for Crowd Funding on IndieGoGo.com 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 2In Vitro Fertilization (IVF) was the Subject of This Year’s Winning Entry for the Prestigious Library of Congress “Discovery or Exploration in History Award” 3Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 2Clinovo White Papers Published in Summer 2014 Editions of Leading Medical Device & Pharmaceutical Publications 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 2PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 3PlaqueTec sichert sich CE-Kennzeichnung für Liquid Biopsy System - bahnbrechende Innovation zur Erfassung neuer biologischer Informationen aus erkranktem Herzkranzgefäß 4
... only Web-based solution for managing compliance and regulated content throughout ... , SAN DIEGO, June 22 Drug ... Virtify, Inc. , the market leader in enterprise ... upcoming release of its Virtx integrated software suite, an end-to-end, ...
... alternative to Singulair and Zicam - The ALCAT Test , ... FDA knocked the wind out of asthmatics by requesting the ... drug, to upgrade their warning against psychotic side effects. Further ... also last week announced warnings that the drug may cause ...
... , , SINGAPORE, June 22 Globally, the largest ... achieve a reduction in CO2 emissions by 8.0 percent between 2008 ... 5.75 percent bio-fuels of all transportation fuel by December 2010 and ... market, it is witnessing rapid growth in terms of both new ...
Cached Biology Technology:Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies 2Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies 3Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies 4Virtify, Inc. Delivers Industry's First Enterprise Content Compliance Software Suite for Life Sciences Companies 5Knocking the Wind Out of Asthmatics: Help from Hippocrates 2Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 2Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 3Government Mandates Create Guaranteed Market for Bio-Fuel, Says Frost & Sullivan 4
Sheep polyclonal to Streptomycin ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule: Streptomycin conjugated to BSA....
Rabbit polyclonal to MAL ( Abpromise for all tested applications). entrezGeneID: 4118 SwissProtID: P21145...
Glutamate Receptor 5/1a...
Mouse monoclonal [3G8] to MDMA ( Abpromise for all tested applications)....
Biology Products: