Navigation Links
U of M researchers identify 2 FDA approved drugs that may fight HIV
Date:8/20/2010

Researchers at the University of Minnesota Academic Health Center have identified two drugs that, when combined, may serve as an effective treatment for HIV.

The two drugs, decitabine and gemcitabine both FDA approved and currently used in pre-cancer and cancer therapy were found to eliminate HIV infection in the mouse model by causing the virus to mutate itself to death an outcome researchers dubbed "lethal mutagenesis."

This is a landmark finding in HIV research because it is the first time this novel approach has been used to attack the deadly virus without causing toxic side effects. Because decitabine and gemcitabine are already FDA approved, researchers believe that if their research is effective in large animal models, it will be much easier to expedite the development of the drugs for human use.

The study is a collaboration between molecular virologists Louis Mansky, Ph.D., and Christine Clouser, Ph.D., of the Institute for Molecular Virology and School of Dentistry, as well as medicinal chemist Steven Patterson, Ph.D., from the Center for Drug Design. The findings were recently published online in the Journal of Virology.

"The findings provide hope that such an approach will someday help the 33 million people worldwide who currently live with HIV," Mansky said.

Lethal mutagenesis

HIV mutates and evolves quickly. Rather than inhibiting virus growth and replication like current HIV drugs, this new drug combination forces the virus to do just the opposite evolve beyond control, to the point of extinction.

"HIV's ability to mutate makes it difficult to target and treat," Mansky said. "We wanted to take advantage of this behavior by stimulating HIV's mutation rate, essentially using the virus as a weapon against itself."

Drug repositioning

One way to decrease cost and expedite the development of novel drugs is by the use of drug repositioning, the process of taki
'/>"/>

Contact: Sarah Hamman
hamma041@umn.edu
612-624-7403
University of Minnesota
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers advance understanding of enzyme that regulates DNA
2. Juelich researchers take a look inside molecules
3. Researchers: Cures to diseases may live in our guts
4. Researchers discover how the storehouses of plant cells are formed
5. Mount Sinai researchers discover new mechanism behind cellular energy conversion
6. ISU researchers discover cause of immune system avoidance of certain pathogens
7. Researchers develop MRSA-killing paint
8. Researchers discover genetic link between immune system, Parkinsons disease
9. Ben-Gurion U. researchers receive US-AID MERC grant for water project with the Palestinian authority
10. Illinois researchers use pyrosequencing to study canine intestinal bacteria
11. Researchers find that one type of stem cell creates a niche for another type in bone marrow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... transplantation of mesenchymal stem cells can stimulate neurogenesis in ... Alzheimer,s disease (AD) and improve tissue and function injury ... reported on the therapeutic effect of adipose-derived stem cells ... effect on oxidative injury and neurogenesis in the brain ... School of Life Sciences, Tsinghua University, China transplanted ADSCs ...
(Date:7/11/2014)... hippocampus, the marginal division of the striatum is ... the impact degree of substance P in the ... Yan Yu and his team, College of Biophotonics, ... staining, that substance P receptor, neurokinin 1 was ... division of normal rats. Unilateral or bilateral injection ...
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
Breaking Biology News(10 mins):
... 2011 With millions of people warding off winter,s ... raising red flags about the potential health effects of ... in the American Chemical Society,s (ACS,) journal, Chemical ... inhaled into the lungs from wood smoke may have ...
... Darwin, the "tree of life" has been the preeminent metaphor ... changing of individual species. The discovery that a large ... species of fungus to another, however, significantly strengthens the argument ... more appropriate. "The fungi are telling us something important ...
... reports that family mealtimes that contain three ingredients in the ... who have chronic asthma. "Family mealtimes, when they,re done ... reduced risk of substance abuse, eating disorders, and obesity. In ... we can see minute by minute which factors deliver these ...
Cached Biology News:Discovery of jumping gene cluster tangles tree of life 2Discovery of jumping gene cluster tangles tree of life 3Recipe for family mealtimes calls for 3 ingredients in the right amounts 2
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... "International Transfection Technology Market - Global Industry Analysis, ... report to their offering. ... to introduce nucleic acids (either DNA or RNA) into ... therapy, mutation of cancer cells and protein metabolism by ...
(Date:7/11/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its new ... GLOBAL MARKETS , the global market for digital polymerase ... 2013. This is estimated to grow to $490 billion ... (CAGR) of 28.6%. , New digital PCR technology has ... the broader PCR field. The opportunities presented by this ...
(Date:7/11/2014)... EPFL and the University of  Geneva  (UNIGE) ... P. Donoghue . The American neuroscientist is to head ... The new Wyss Center for Bio- and Neuro-Engineering, ... , has named as its director one of the ... founder of Brown University,s Institute for Brain Science, has ...
(Date:7/11/2014)... - Sunovion Pharmaceuticals Canada Inc. (Sunovion) today announced that ... use as a once-daily adjunctive therapy for the treatment ... not satisfactorily controlled with conventional therapy.  APTIOM TM ... years of age. Epilepsy is one ... Epilepsy Canada, it affects 0.6% of the population and ...
Breaking Biology Technology:International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 2Global Market for Digital Polymerase Chain Reaction Technology to Reach $490 Billion by 2018; Equipment Sector Accounts for the Fastest Growing Segment With 33% CAGR 3John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 2Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 3Sunovion Pharmaceuticals Canada Inc. Announces Health Canada Approval of APTIOM(TM) (eslicarbazepine acetate) as a Once-Daily Adjunctive Treatment for Partial-Onset Seizures in Patients with Epilepsy 4
... Radio frequency identification technology is often touted as a way ... world, the technology is bringing other, perhaps more important benefits: ... supply chain now, and there are tremendous applications in health ... the marketplace," said Reik Read, an analyst with Robert ...
... Madison, Wis. Wisconsin's research and development funding has exceeded expectations, reaching ... had set a target of $3.3 billion by 2005. , ... R&D spending per capita, and 13 th in academic R&D ... match the growth rate in R&D the last few years," said ...
... - TEKLYNX International a developer of ... (AIDC) marketplace, has announced LABELVIEW 8 label design and ... code label printing. , ,The updates enhance label ... greatly extend Pocket LABELVIEW printer support to over 1,000 ...
Cached Biology Technology:RFID can be a matter of life and death in the medical world 2RFID can be a matter of life and death in the medical world 3RFID can be a matter of life and death in the medical world 4RFID can be a matter of life and death in the medical world 5New report says Wisconsin R&D spending exceeding expectations 2
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Immunogen: Tissue / cell preparation. (Murine EHS laminin preparation) Storage: -20 C, Avoid Freeze/Thaw Cycles...
p-Raf-1 (Ser 338/Tyr 341)-R...
Rabbit polyclonal to Syntrophin alpha 1 ( Abpromise for all tested applications). entrezGeneID: 6640 SwissProtID: Q13424...
Biology Products: