Navigation Links
U of M researchers discover gene required to maintain male sex throughout life
Date:7/20/2011

MINNEAPOLIS / ST. PAUL (July 20, 2011) University of Minnesota Medical School and College of Biological Sciences researchers have made a key discovery showing that male sex must be maintained throughout life.

The research team, led by Drs. David Zarkower and Vivian Bardwell of the U of M Department of Genetics, Cell Biology and Development, found that removing an important male development gene, called Dmrt1, causes male cells in mouse testis to become female cells.

The findings are published online today in Nature.

In mammals, sex chromosomes (XX in female, XY in male) determine the future sex of the animal during embryonic development by establishing whether the gonads will become testes or ovaries.

"Scientists have long assumed that once the sex determination decision is made in the embryo, it's final," Zarkower said. "We have now discovered that when Dmrt1 is lost in mouse testes even in adults many male cells become female cells and the testes show signs of becoming more like ovaries."

Previous research has shown that removing a gene, called Foxl2, in ovaries caused female cells to become male cells and the ovaries to become more like testes. According to Zarkower, the latest U of M research determines that the gonads of both sexes must actively maintain the original sex determination decision throughout the remainder of life.

For the genetic research community this new understanding is a breakthrough. The findings provide new insight into how to turn one cell type into another, a process known as reprogramming, and also show that throughout life, cells in the testis must be actively prevented from transforming into female cells normally found in the ovary.

"This work shows that sex determination in mammals can be surprisingly prone to change, and must be actively maintained throughout an organism's lifetime," said Dr. Susan Haynes, who oversees developmental biology grants at the N
'/>"/>

Contact: Kelly O'Connor
oconn246@umn.edu
612-624-5680
University of Minnesota
Source:Eurekalert

Page: 1 2

Related biology news :

1. Caltech researchers create the first artificial neural network out of DNA
2. Western researchers receive $600,000 to study Prion diseases and Alzheimers
3. Researchers find potential key for unlocking biomass energy
4. Researchers present new trends in HIV cure research, call for proactive outreach programs to prevent HIV transmission in injecting drug users, and demand increased commitments to improving maternal and child health
5. E-health records should play bigger role in patient safety initiatives, researchers advocate
6. John Theurer Cancer Center researchers shared 14 leading edge studies at recent ASCO meeting
7. Researchers provide means of monitoring cellular interactions
8. USC researchers explore the source of empathy in the brain
9. Penn vet researchers show lymphoma drug shrinks dog tumors, could lead to human treatment
10. Wood products part of winning carbon-emissions equation, researchers say
11. IRCM researchers uncover a new piece of the puzzle in the development of our nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... EMBO today announced Sophie Martin of the University ... EMBO Gold Medal. The award acknowledges her work to ... development of the cell. , Martin has been working ... in particular the way in which the spatial organization ... In the last 11 years, she has been using ...
(Date:4/23/2014)... Like many social mammals, ravens form different types of ... partners and they also form strict dominance relations. From ... is a key ability in daily social life ("knowing ... relationships group members have with each other sets the ... The results of this study have been published in ...
(Date:4/22/2014)... There are all sorts of signaling strategies in nature. ... tails; satin bowbirds build specialized stick structures, called bowers, ... European bitterling males show off bright nuptial coloration during ... to communicate with others. , ... profound fitness implications for individuals that are either signaling ...
Breaking Biology News(10 mins):EMBO Gold Medal 2014 awarded to Sophie Martin 2Ravens understand the relations among others 2Best practices in communication for the animal world 2Best practices in communication for the animal world 3
... shows that male rats prenatally exposed to low doses of ... prostate inflammation and to go through puberty later than non-exposed ... on atrazine, an herbicide predominantly used to control weeds and ... and its byproducts are known to be relatively persistent in ...
... desire to understand how breast cancer starts has seen ... today win one of three 2010 L,Oreal Australia For ... postdoctoral fellow in the institute,s Stem Cells and Cancer ... profile for her studies of how breast stem cells ...
... FL Nova Southeastern University (NSU) is using part of a ... the Gulf Oil Spill,s impact on the marine ecosystem, officials ... of several educational institutions in Florida selected to work on ... the Gulf,s ecosystem and marine life. The projects were selected ...
Cached Biology News:Atrazine causes prostate inflammation in male rats and delays puberty 2L'Oreal Fellowship winner seeks to understand breast cancer 2NSU scientists receive BP money to research oil spill's impact 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... Ontario , Jan. 14, 2014   Kinaxis ®, provider ... SCM ) and sales and operations planning ( S&OP ) ... Biomanufacturing Summit , which will be held at the ... the conference, join Kinaxis customer Elisabeth Kaszas , Director ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... ,, PORTLAND, Ore. , June 15 ... the use of genomic data in clinical decision making—will be addressing ... in personalized treatments for cancer patients. , ... "If you were diagnosed with non ...
... and WALTHAM, Mass. , June 15, 2010 ... LLY ) and Alkermes, Inc. (Nasdaq: ALKS ) today announced results ... superiority of BYDUREON™ (exenatide extended-release for injectable suspension), an investigational type 2 diabetes ... , , ...
... ... have entered into a research collaboration with the goal of bringing more relevant and ... ... -- Cellular Dynamics International (CDI) and Promega have entered into a research collaboration with ...
Cached Biology Technology:Personalized Treatments for Cancer Are Revolutionizing Patient Care 2Personalized Treatments for Cancer Are Revolutionizing Patient Care 3DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 2DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 3DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 4DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 5DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 6DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 7DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 8DURATION-4 Study Results: BYDUREON Efficacy and Tolerability Profile Extended to Monotherapy Treatment 9Promega and Cellular Dynamics Partner to Validate Stem Cell-Based In Vitro Assays for Predicting Drug-Induced Cardiotoxicity 2Promega and Cellular Dynamics Partner to Validate Stem Cell-Based In Vitro Assays for Predicting Drug-Induced Cardiotoxicity 3
... RNase ONE Ribonuclease is a 27kDa periplasmic ... degradation of RNA to cyclic nucleotide monophosphate ... degradation of these intermediates to 3-NMPs (1). ... few known RNases that can cleave a ...
The Holten Safe 2010 Class II Biological Safety Cabinets provide the most ergonomical working condition of comfort while incorporating the latest technology for safety, efficiency and performance....
... HM-4000 Multidizer is designed with a variety ... rotating - all in one unit. Shake, ... independently operating compartments allow for hybridization and ... motion , The upper chamber uses ...
... is designed for paramagnetic bead precipitation from ... PCR plates with no additional accessories. The ... a standard SBS 96-well microplate footprint. The ... guarantees easy and fast (as little as ...
Biology Products: