Navigation Links
U of M researchers develop model for better testing, targeting of MPNST
Date:5/20/2013

MINNEAPOLIS/ST. PAUL (MAY 20, 2013) University of Minnesota Medical School researchers from the Masonic Cancer Center, University of Minnesota, in partnership with the University's Brain Tumor Program, have developed a new mouse model of malignant peripheral nerve sheath tumors (MPNST) that allow them to discover new genes and gene pathways driving this type of cancer.

The research was published this week in the journal Nature Genetics.

Utilizing the Sleeping Beauty transposon method, researchers in the lab of David Largaespada, Ph.D., professor in the Medical School and College of Biological Sciences, were able to use an unbiased approach to generate mouse models of MPNST development that lead to the identification of genes related to this tumor's development.

MPNST is a genetically diverse, aggressive form of sarcoma impacting connective tissue surrounding nerves that occurs sporadically or in association with Neurofibromatosis Type 1 (NF1) syndrome. The exact cause of MPNST is not known, but symptoms include swelling in the arms and legs, soreness and stiffness at the site of the tumor. MPNSTs are the most common malignancy in adults with NF1 syndrome and leading cause of NF1-related mortality.

Due to the invasive nature and high incidence of metastasis of MPNSTs, surgical resection, radiotherapy and chemotherapeutic treatments have proven to be ineffective for long-term treatment, resulting in 5-year survival rates of less than 25 percent with metastatic disease.

One of the most surprising findings in this research showed the gene FOXR2 is intrinsically linked to the growth of MPNSTs. This gene has not been heavily studied as researchers had not identified a clear function of this gene.

"By using an unbiased approach, it helped us identify FOXR2 as an important gene in MPNST development and develop experiments to pinpoint the role FOXR2 plays in maintaining the aggressive nature of these tumo
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
3. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
4. UNH researchers find African farmers need better climate change data to improve farming practices
5. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
6. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
7. Researchers print live cells with a standard inkjet printer
8. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
9. Researchers reveal how a single gene mutation leads to uncontrolled obesity
10. Researchers discover novel therapy for Crohns disease
11. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... ("Company") (BM&FBOVESPA: VLID3 ON), is pleased to inform its shareholders ... Washington,s Department of Licensing, in the United States, awarded ... for driver,s licenses and identification cards to its subsidiary, Valid ... start in January 2015, with enrollment and card production starting ...
(Date:1/22/2015)... MELBOURNE, Fla. , Jan. 13, 2015  Today, ... wearable technology, launched its crowdfunding campaign on Fundable, ... accelerate the build of production capacity to meet ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... MADISON, Wis. , Jan. 15, 2015  BellBrook ... for drug discovery, announced the launch of a ... of the company,s Transcreener UDP Assay, a high ... enzymes. The new assay will allow for sensitive ...
Breaking Biology News(10 mins):Valid USA Signs Contract For Washington Driver's License Issuance 2FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2
... National Osteoporosis Foundation, osteoporosis affects more than 2 million ... more have osteopeniaclinically significant low bone density that is ... the University of Missouri-Columbia has found that men engaging ... incidence of osteopeniaa condition resulting in two times the ...
... at the University of Illinois published a discovery that challenged ... which was based on an analysis of ribosomal RNA, ... opened up a new field of study, and established ... To mark the anniversary of this discovery, the university is ...
... of human bones is vastly different than previously believed ... debilitating bone disorders are treated. Researchers from the ... and the BAM Federal Institute of Materials Research and ... stiffness of bone is predominantly due to the presence ...
Cached Biology News:Study shows some athletic men may risk low bone density 2Symposium marks 30th anniversary of discovery of third domain of life 2Symposium marks 30th anniversary of discovery of third domain of life 3Symposium marks 30th anniversary of discovery of third domain of life 4New research on structure of bones raises questions for treatment of osteoporosis 2
(Date:2/26/2015)... S&P Capital IQ (MHFI) announced today that ... MabVax Therapeutics Holdings Inc . MabVax ... company focused on the development of vaccine and antibody-based ... of cancer. MabVax has discovered a pipeline of human ... generated by patients who have been immunized against targeted ...
(Date:2/26/2015)... --  Synageva BioPharma Corp. (NASDAQ: ... for rare disorders, today reported 2014 full year ... objectives, and financial guidance.  Synageva,s management team will ... EST to review the financial results and provide ... call by telephone, please dial (877) 445-4603 for ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 The Movement ... demonstration to support life extension technologies and awareness. The ... Universal Coordinated Time, on March 21st 2015, in a ... , Eric Schulke, Founder of MILE, says, “Our ... with urgency. The Movement for Indefinite Life Extension is ...
(Date:2/26/2015)... 2015 BioEnterprise today announced that ... than $2 billion in growth funding during the past ... strategic sources, state – including the Ohio Third Frontier ... billion has been raised in the past five years. ... of the BioEnterprise Midwest Healthcare Growth Capital  Report. ...
Breaking Biology Technology:S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 5Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9Indefinite Life Extension Activists Organize Online Demonstration 2Indefinite Life Extension Activists Organize Online Demonstration 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 2More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 3More Than $2 Billion Invested in Northeast Ohio Bioscience Start-Up Companies Since 2002 4
... Nanotechnology will significantly change virtually every facet of ... opportunity to shape these changes and to ensure that ... and controlled. A new report by former EPA official ... for the next presidential administration and describes the immediate ...
... Calif., July 23 Sangamo,BioSciences, Inc. (Nasdaq: SGMO ... For the second quarter ended June 30, 2008, ... $0.18 per share, compared to a,net loss of $5.2 ... in 2007.,As of June 30, 2008, the company had ...
... to Present Plans for Regaining Compliance - - NASDAQ ... ... Meets All Other NASDAQ Capital Market Initial Listing ... Rule -, TUSTIN, Calif., July 23 Peregrine,Pharmaceuticals, Inc. (Nasdaq: ...
Cached Biology Technology:Nanotech: A regulatory blueprint for the next administration 2Sangamo BioSciences Reports Second Quarter 2008 Financial Results 2Sangamo BioSciences Reports Second Quarter 2008 Financial Results 3Sangamo BioSciences Reports Second Quarter 2008 Financial Results 4Sangamo BioSciences Reports Second Quarter 2008 Financial Results 5Sangamo BioSciences Reports Second Quarter 2008 Financial Results 6Sangamo BioSciences Reports Second Quarter 2008 Financial Results 7Sangamo BioSciences Reports Second Quarter 2008 Financial Results 8Peregrine Pharmaceuticals Receives Letter from NASDAQ Citing Failure to Regain Compliance with Minimum Bid Price Rule 2Peregrine Pharmaceuticals Receives Letter from NASDAQ Citing Failure to Regain Compliance with Minimum Bid Price Rule 3Peregrine Pharmaceuticals Receives Letter from NASDAQ Citing Failure to Regain Compliance with Minimum Bid Price Rule 4