Navigation Links
U of M researchers: Newly discovered genetic markers could signal colon cancer development
Date:8/24/2012

MINNEAPOLIS/ST. PAUL (August 23, 2012) University of Minnesota Medical School and Masonic Cancer Center researchers have partnered with geneticists from Genentech, Inc., to discover how some proteins may cause the development of some forms of colon cancers.

The proteins part of R-spondin family normally help activate cell proliferation during embryonic development. Now, University of Minnesota researchers have discovered that when two types of R-spondins RSPO2 and RSPO 3 are reactivated in adults through certain gene mutations, they can signal cells to restart the cell proliferation process, which can lead to tumor growth in the colon.

The discovery, which involved multiple researchers from the University's Masonic Cancer Center, could lead the way to more personalized colon cancer therapy designed around the genetics of a patient's specific cancer. The results are available online now, in the journal Nature.

"These results suggest there is a potential for personalized therapies based on knowing a tumor's specific genetics," said David Largaespada, Ph.D., associate director of Basic Sciences and professor in the Department of Genetics, Cell Biology and Development. "And because these R-spondins are related to embryonic growth, and seem to not have major roles in the adult, targeting them would likely be low in side effects."

To arrive at the results, researchers analyzed more than 70 pairs of human colon tumors and a mouse model engineered using the Sleeping Beauty transposon by Largaespada. Through a series of investigations, researchers identified 36 rearrangements that result in gene fusions, including two recurrent ones involving R-spondin family members RSPO2 and RSPO3.

While the results could generate more personalized approaches to the treatment of colon cancer, researchers stress more research is needed before these results can be applied to actual patient care.

Caitlin Conboy, an M.D./Ph.D. student studying at
'/>"/>

Contact: Caroline Marin
crmarin@umn.edu
612-624-5680
University of Minnesota Academic Health Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. UCSD researchers: Where international climate policy has failed, grassroots efforts can succeed
2. Newly released FDA draft guidelines for biosimilar drugs to be discussed at conference
3. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
4. Newly discovered foot points to a new kid on the hominin block
5. Newly found protein helps cells build tissues
6. Scientists advance field of research with publication of newly validated method for analyzing flavanols in cocoa
7. Key proteins newly discovered form and function may provide novel cancer treatment target
8. Newly discovered breast milk antibodies help neutralize HIV
9. Newly discovered dinosaur implies greater prevalence of feathers
10. Unexpected crustacean diversity discovered in northern freshwater ecosystems
11. University of Alberta led research may have discovered how memories are encoded in our brains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 2015 The announcement comes as ... Records Management (GRM), Ireland,s foremost records ... Having built up an impressive track record of clients within ... within the records management sector in Dubai ... GCC staffbase and employ a further eight staff members at ...
(Date:4/13/2015)... April 13, 2015 According ... "Global Biometrics Market Forecast & Opportunities, 2020", the global ... of around 14% till 2020. The biometrics market ... scale implementation and review of biometric management systems. ... new products with greater efficiency, are resulting in ...
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
Breaking Biology News(10 mins):Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... mankind and the environment, there is a growing ... and education that new, more integrative approaches to ... multidisciplinary approaches to solving problems at the frontiers ... institutional level. , Integrated Science − New Approaches ...
... Actor and pancreatic cancer patient Patrick Swayze,s recent hospitalization ... system underscores the sensitivity of the lungs: many patients ... the disease itself. Lungs are delicate and exposed ... the body has developed an elaborate immuno-defense system to ...
... over the last few decades in old-growth forests of the ... worrisome trend is regional warming, according to a U.S. Geological ... 23. The study found that the increase in dying ... a wide variety of forest types, at all elevations, in ...
Cached Biology News:Research elucidates way lungs fight bacteria and prevent infection 2Tree deaths have doubled across the western US 2
(Date:5/20/2015)... 20, 2015 The global genotyping market ... during the forecast period of 2015 to 2020 to ... used in drug discovery and development process and to ... In addition to this,heavy investments by key manufacturers to ... also propelling market growth. Browse 113 market data tables ...
(Date:5/20/2015)... 2015  Marc Tessier-Lavigne, president of The Rockefeller ... million from The Marie-Josée and Henry R. Kravis ... that will be the centerpiece of the University,s ... R. Kravis Research Building, two stories high, will ... three city blocks following the shoreline of the ...
(Date:5/20/2015)...  Resolution Bioscience announced today the successful results from ... , a blood-based liquid biopsy for an ALK-gene fusion driver ... most common form of this cancer. Researchers or clinicians ... personalized therapies and direct them into clinical trials with ... Health, the CLIA authority in Washington State ...
(Date:5/20/2015)... MA (PRWEB) May 20, 2015 ... transporter assay services for Drug-Drug Interactions (DDI), Metabolism ... Pharma, a world leader in assessing impact of ... Systems Pharmacology supported by biosimulation, announced today that ... agreement allows both companies to expand their product ...
Breaking Biology Technology:Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 2The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 3The Marie-Josee and Henry R. Kravis Foundation Provides Landmark Gift of $100 Million to The Rockefeller University 4Resolution Bioscience Receives CLIA Certification for its Diagnostic Laboratory and Launches CLIA-Certified Liquid Biopsy for Lung Cancer 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 2Optivia Biotechnology Inc. and Rhenovia Pharma Sign Partnership Agreement 3
... Toronto Stock Exchange Symbol: MS, EDMONTON, Nov. ... leading developer in the treatment of multiple sclerosis ... been enrolled in its MAESTRO-03,U.S. pivotal phase III ... progressive multiple sclerosis (SPMS). An interim safety and,efficacy ...
... Alma Lasers Ltd., a global,leader in the development ... systems, today announced that it has,been named Israel,s ... 50 program. The program is presented by Deloitte ... growth over five years from,2002-2006. Howard Kelly, ...
... Associated with Chronic Pain Conditions in Patients Who ... ... FRAZER, Pa., Nov. 12 Cephalon, Inc. (Nasdaq:,CEPH) today announced ... Food and Drug Administration (FDA) seeking approval to,market FENTORA(R) (fentanyl buccal ...
Cached Biology Technology:BioMS Medical achieves enrollment milestone in U.S. phase III multiple sclerosis trial 2BioMS Medical achieves enrollment milestone in U.S. phase III multiple sclerosis trial 3Alma Lasers Ranked 9th in Deloitte Technology Fast 50 Award 2Cephalon Submits Supplemental New Drug Application for FENTORA 2Cephalon Submits Supplemental New Drug Application for FENTORA 3Cephalon Submits Supplemental New Drug Application for FENTORA 4Cephalon Submits Supplemental New Drug Application for FENTORA 5Cephalon Submits Supplemental New Drug Application for FENTORA 6Cephalon Submits Supplemental New Drug Application for FENTORA 7
Dako Target Retrieval Solution, Citrate pH 6 (x 10) For more information, please visit Dako' web-site. EU regulatory status: CE US regulatory status: IVD...
... data acquisition interface. All the functionality of ... processor, increased memory and more available channels ... also inlcudes an option for programmable front-end ... 16 to 48 waveform inputs and from ...
... to off-white solid. Increases the expression of glutathione ... in H 2 O. Unstable in aqueous ... EK7713840, CAS 3211-76-5, M.W. 196.1. References: ... and Junod, A.F. 1995. Biochem. J. ...
... designed to provide a thin film-like barrier when a ... This barrier creates the proper surface tension to ... the slide. PAP Pen contains a special formulation ... can be removed, if desired, by xylene after the ...
Biology Products: