Navigation Links
U of M researcher helps unlock 30 new genes responsible for early onset puberty
Date:12/1/2010

MINNEAPOLIS / ST. PAUL (December 1, 2010) University of Minnesota School of Public Health researcher Ellen Demerath, Ph.D., is among an international group of researchers that has identified 30 new genes responsible for determining the age of sexual maturation in women. Many of these genes are also known to influence body fatness, obesity, and energy metabolism. Prior to the multi-institutional study, only four genes had been identified as contributing to the process.

The findings, which were reported in Nature Genetics, help to explain why girls who are obese tend to have earlier puberty: some of the same genes are involved in both outcomes. Early menarche, or the first menstrual cycle, is linked to a variety of chronic adulthood diseases, including breast cancer, cardiovascular diseases, and type 2 diabetes.

As a result of these discoveries, Demerath suggests that health care providers and other professionals pay particularly close attention to girls with a high risk of obesity (those who are overweight in childhood or who have a parental history of obesity) and intervene with them, as those girls are also genetically more susceptible to early menarche.

"Early menarche is caused by both genetics and environmental factors," said Demerath. "We already knew that diet and physical exercise play a role in menarche, but now that we've identified more of the specific genes involved, this gives us clues about how to intervene on the process. By showing how hereditary and biological factors contribute to early menarche, we hope to one day allow health care providers to identify girls with increased risk of early menarche, and help them avoid the complications of early-onset puberty."

In the large-scale, NIH-funded study, researchers from 104 institutions collected data from more than 100,000 women from the United States, Europe, and Australia. This includes women from the Twin Cities area enrolled in the Atherosclerosis Risk in Communities (ARIC) study. Not only were researchers able to identify these new genes, but they also found that many of them play a role in body weight regulation or biological pathways related to fat metabolism. The study findings also suggest that menarche is a result of a complex range of biological processes.

Today, girls are menstruating earlier than ever before. In the mid-1900s, the average age of menarche was 14-15 years. The average age today is 12-13 years.

"We now know that hormone regulation, cell development, and other mechanisms are related to menarche," said Demerath.

According to Demerath, the next step for researchers is to examine whether some of these genes also influence sexual development in males, whether the genes are related to general growth in size as well as development, the points in the life cycle when the genes are most powerfully expressed, and how environmental factors such as diet and physical activity can modify their effects.


'/>"/>

Contact: Emily Jensen
jense888@umn.edu
612-624-9163
University of Minnesota
Source:Eurekalert

Related biology news :

1. Researchers find link between sugar, diabetes and aggression
2. Snakes on a rope: Researchers take a unique look at the climbing abilities of boa constrictors
3. Pitt researcher receives NIH funding for technology-enhanced weight-loss program
4. Researcher explores the evolution of largest mammals over the past 100 million years
5. University of Minnesota engineering researcher finds new way to fight antibiotic-resistant bacteria
6. Iowa State, Ames Lab researcher develops new way to study single biological molecules
7. Researchers kick-start ancient DNA
8. Gene links to anorexia found by Childrens Hospital of Philadelphia researchers
9. UGA researchers identify key enzyme that regulates the early growth of breast cancer cells
10. Researchers insert identification codes into mouse embryos
11. Researchers learn that genetics determine winter vitamin D status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... ... 16, 2017 , ... Today, 3Bar Biologics Inc ., ... in funding from an impressive group of investors, including Rev1 Ventures, Maumee Ventures, ... this investment, 3Bar is broadening availability of its groundbreaking offering that uses naturally ...
(Date:8/15/2017)... 15, 2017 After spending the past two years building ... data collection, GeneFo now offers this platform to healthcare stakeholders (hospitals, ... support, adherence, and data collection vis a vis their members, under ... successful launch of this offer. ... GeneFo ...
(Date:8/15/2017)... , ... August 15, 2017 , ... Any expert in ... has compromised these disciplines for more than half a century. Despite their essential ... It is widely known that molecular tags developed for this purpose also tag ...
(Date:8/15/2017)... ... 2017 , ... JULABO USA introduces its new website ... it easy to navigate through the site whether you’re in the office, in ... educational industry content and visit the company’s social media accounts, all on one ...
Breaking Biology Technology: