MINNEAPOLIS / ST. PAUL (December 1, 2010) University of Minnesota School of Public Health researcher Ellen Demerath, Ph.D., is among an international group of researchers that has identified 30 new genes responsible for determining the age of sexual maturation in women. Many of these genes are also known to influence body fatness, obesity, and energy metabolism. Prior to the multi-institutional study, only four genes had been identified as contributing to the process.
The findings, which were reported in Nature Genetics, help to explain why girls who are obese tend to have earlier puberty: some of the same genes are involved in both outcomes. Early menarche, or the first menstrual cycle, is linked to a variety of chronic adulthood diseases, including breast cancer, cardiovascular diseases, and type 2 diabetes.
As a result of these discoveries, Demerath suggests that health care providers and other professionals pay particularly close attention to girls with a high risk of obesity (those who are overweight in childhood or who have a parental history of obesity) and intervene with them, as those girls are also genetically more susceptible to early menarche.
"Early menarche is caused by both genetics and environmental factors," said Demerath. "We already knew that diet and physical exercise play a role in menarche, but now that we've identified more of the specific genes involved, this gives us clues about how to intervene on the process. By showing how hereditary and biological factors contribute to early menarche, we hope to one day allow health care providers to identify girls with increased risk of early menarche, and help them avoid the complications of early-onset puberty."
In the large-scale, NIH-funded study, researchers from 104 institutions collected data from more than 100,000 women from the United States, Europe, and Australia. This includes women from the Twin Cities area enrolled in the Atherosclerosis
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University of Minnesota