Navigation Links
U of I study: Lose body weight before gaining baby weight
Date:4/12/2012

URBANA A new University of Illinois study contains a warning for obese women who are planning pregnancies. Even if they eat a healthy diet when they are pregnant, their babies will develop in an unhealthy environment that places the infants at risk for future health problems.

"We can see fat sequestered in the placentas of obese mothers when it should be going to the baby to support its growth. The nutrient supply region in the placenta of an obese mother is half the size of that of a normal-weight mother, even when both are eating the same healthy diet," said Yuan-Xiang Pan, a U of I professor of nutrition.

Pan blames what he calls the obesogenic environment of the mother, which includes increased triglycerides, high levels of the hormone leptin, and elevated amounts of non-esterified fatty acids (NEFAs) circulating in the obese expectant mother's body. Triglyceride and NEFA levels are nearly twice as high in obese mothers, even when they consume healthy diets during pregnancy, he said.

"My advice is, lose weight well before you become pregnant," Pan said.

In the study, the scientist compared the placentas of obese rats fed a healthy diet throughout their pregnancies with the placentas of obesity-resistant rats fed the same diet.

"Although the obese females didn't gain much weight on the healthy diet, the obesogenic environment remained, and it affected nutrient transport regulation in the placenta," he said.

As a result, obese mothers gave birth to babies that were up to 17 percent smaller than they should have been. The consequences for those infants may be lifelong, making them more susceptible to disease, he noted.

Pan, an epigeneticist, was able to demonstrate for the first time that the DKK1 gene regulates certain aspects of lipid metabolism in the placenta through the WNT signaling pathway.

"Understanding this process should help us identify some biomarkers that would allow a potential mother's doctor to say yes, you've lost weight, the chemical conditions that were created by your excess weight are gone, and this is a good time for you to become pregnant," he said.

Biomarkers could also be useful in testing new babies. If doctors can see that the mother's pre-pregnancy and pregnancy diets were deficient, there might be ways to compensate for that poor prenatal environment, he said.

"The point I'd like to get across to women of child-bearing age is that they must pay attention to their weight well before they become pregnant if they want to have a healthy baby. Obesity creates unhealthful conditions in the mother's body that take time to correct. A healthy mother will give birth to a baby that is more resistant to disease," he said.


'/>"/>
Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related biology news :

1. Study: urban black bears live fast, die young
2. Study: Bird diversity lessens human exposure to West Nile Virus
3. Study: Tropical wetlands hold more carbon than temperate marshes
4. Study: Wildlife need more complex travel plans
5. Study: Elderly Women can increase strength but still risk falls
6. UNC study: Text messaging may help children fight off obesity
7. Study: Did early climate impact divert a new glacial age?
8. Study: Excessive use of antiviral drugs could aid deadly flu
9. UNC study: Tinkering with the circadian clock can suppress cancer growth
10. Study: Fluid buildup in lungs is part of the damage done by the flu
11. Study: Health undervalued in reproductive rights debate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/12/2016)... -- Researchers at Trinity College, Dublin, are opening up ... material with Silly Putty. The mixture (known as "G-putty") ... sense pulse, blood pressure, respiration, and even the ... The research team,s findings were published Thursday in ... Due ...
(Date:12/7/2016)... December 7, 2016 BioCatch , the global ... its patent portfolio, which grew to over 40 granted and pending patents. ... , , ... patent entitled " System, Device, and Method Estimating Force Applied ... device makers to forego costly hardware components needed to estimate the force ...
(Date:12/6/2016)... Valencell , the leading innovator in performance biometric ... consecutive year of triple digit growth for its PerformTek ... 360 percent increase in companies who have acquired Valencell ... sales of its wrist and ear Benchmark™ sensor systems, ... hearables for fitness and healthcare applications. ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... , Jan. 18, 2017  HUYA Bioscience International, (HUYA), ... China,s pharmaceutical innovations, announced today a ... Innovation and Investment Company (referred to as CAS Innovation). ... innovations discovered by leading scientists at CAS to meet ... HUYA is the first company to have recognized ...
(Date:1/18/2017)... Research Future published a half-cooked research report on Global Cancer Diagnostics ... CAGR of 12% during the period 2016 to 2022. ... ... without any control. These abnormal cells have the ability to invade ... spread to other parts of the body through the blood and ...
(Date:1/17/2017)... The Global Implantable Biomaterials Market is ... 7.5% over the next decade to reach approximately ... trends that the market is witnessing include increasing ... transplant surgeries and medical implants and technological advancements. ... into immunomodulatory biomaterials, natural, polymers, hydrogels and ceramics. ...
(Date:1/17/2017)...  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... and earnings conference call will be broadcast live over ... a.m. Eastern Time.  A news release detailing the quarterly ... a.m. Eastern Time the morning of the conference call. ... via Zimmer Biomet,s Investor Relations website at http://investor.zimmerbiomet.com ...
Breaking Biology Technology: