Navigation Links
U of I study: Lose body weight before gaining baby weight
Date:4/12/2012

URBANA A new University of Illinois study contains a warning for obese women who are planning pregnancies. Even if they eat a healthy diet when they are pregnant, their babies will develop in an unhealthy environment that places the infants at risk for future health problems.

"We can see fat sequestered in the placentas of obese mothers when it should be going to the baby to support its growth. The nutrient supply region in the placenta of an obese mother is half the size of that of a normal-weight mother, even when both are eating the same healthy diet," said Yuan-Xiang Pan, a U of I professor of nutrition.

Pan blames what he calls the obesogenic environment of the mother, which includes increased triglycerides, high levels of the hormone leptin, and elevated amounts of non-esterified fatty acids (NEFAs) circulating in the obese expectant mother's body. Triglyceride and NEFA levels are nearly twice as high in obese mothers, even when they consume healthy diets during pregnancy, he said.

"My advice is, lose weight well before you become pregnant," Pan said.

In the study, the scientist compared the placentas of obese rats fed a healthy diet throughout their pregnancies with the placentas of obesity-resistant rats fed the same diet.

"Although the obese females didn't gain much weight on the healthy diet, the obesogenic environment remained, and it affected nutrient transport regulation in the placenta," he said.

As a result, obese mothers gave birth to babies that were up to 17 percent smaller than they should have been. The consequences for those infants may be lifelong, making them more susceptible to disease, he noted.

Pan, an epigeneticist, was able to demonstrate for the first time that the DKK1 gene regulates certain aspects of lipid metabolism in the placenta through the WNT signaling pathway.

"Understanding this process should help us identify some biomarkers that would allow a potential mother's doctor to say yes, you've lost weight, the chemical conditions that were created by your excess weight are gone, and this is a good time for you to become pregnant," he said.

Biomarkers could also be useful in testing new babies. If doctors can see that the mother's pre-pregnancy and pregnancy diets were deficient, there might be ways to compensate for that poor prenatal environment, he said.

"The point I'd like to get across to women of child-bearing age is that they must pay attention to their weight well before they become pregnant if they want to have a healthy baby. Obesity creates unhealthful conditions in the mother's body that take time to correct. A healthy mother will give birth to a baby that is more resistant to disease," he said.


'/>"/>
Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related biology news :

1. Study: urban black bears live fast, die young
2. Study: Bird diversity lessens human exposure to West Nile Virus
3. Study: Tropical wetlands hold more carbon than temperate marshes
4. Study: Wildlife need more complex travel plans
5. Study: Elderly Women can increase strength but still risk falls
6. UNC study: Text messaging may help children fight off obesity
7. Study: Did early climate impact divert a new glacial age?
8. Study: Excessive use of antiviral drugs could aid deadly flu
9. UNC study: Tinkering with the circadian clock can suppress cancer growth
10. Study: Fluid buildup in lungs is part of the damage done by the flu
11. Study: Health undervalued in reproductive rights debate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2016)... Israel , April 14, 2016 ... Authentication and Malware Detection, today announced the appointment of ... assumed the new role. Goldwerger,s leadership appointment ... on the heels of the deployment of its platform ... BioCatch,s behavioral biometric technology, which discerns unique cognitive and ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
(Date:3/29/2016)... , March 29, 2016 LegacyXChange, ... LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to announce ... used in a variety of writing instruments, ensuring athletes ... originally created collectibles from athletes on LegacyXChange will be ... of the DNA. Bill Bollander , ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... April 29, 2016 , ... ... used in spinal surgical procedures, today announced the completion of a significant transaction ... for current and future customers and partners. Kohlberg & Company, L.L.C. (“Kohlberg”), ...
(Date:4/29/2016)... , April 29, 2016 ... by Transparency Market Research "Separation Systems for Commercial ... Growth, Trends, and Forecast 2015 - 2023", the ... at US$ 10,665.5 Mn in 2014 and is ... from 2015 to 2023 to reach US$ 19,227.8 ...
(Date:4/29/2016)... ... 29, 2016 , ... During a two day program for ... company, CereScan’s CEO, John Kelley, joined other Denver business leaders in providing business ... the Denver area business community, shared his top fundamental learnings in building an ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... Summit ... (NSCF) to support the development of a patient-specific stem cell therapy for the treatment ... the lab of Dr. Jeanne Loring at The Scripps Research Institute in San Diego, ...
Breaking Biology Technology: