Navigation Links
U of I study: Lack of omega-6 fatty acid linked to severe dermatitis
Date:4/12/2010

URBANA University of Illinois scientists have learned that a specific omega-6 fatty acid may be critical to maintaining skin health.

"In experiments with mice, we knocked out a gene responsible for an enzyme that helps the body to make arachidonic acid. Without arachidonic acid, the mice developed severe ulcerative dermatitis. The animals were very itchy, they scratched themselves continuously, and they developed a lot of bleeding sores," said Manabu Nakamura, a U of I associate professor of food science and human nutrition.

When arachidonic acid was added to the animals' diet, the itching went away, he said.

Nakamura's team has been focusing on understanding the function of omega-3 and -6 fatty acids, and doctoral student Chad Stroud developed a mouse model to help them understand the physiological roles of these fats. By knocking out genes, they can create deficiencies of certain fats and learn about their functions.

"Knocking out a gene that enables the body to make the delta-6-desaturase enzyme has led to some surprising discoveries. In this instance, we learned that arachidonic acid is essential for healthy skin function. This new understanding may have implications for treating the flaky, itchy skin that sometimes develops without an attributable cause in infants," he said.

Nakamura explained that our bodies make arachidonic acid from linoleic acid, an essential fatty acid that we must obtain through our diets. It is found mainly in vegetable oils.

Scientists have long attributed healthy skin function to linoleic acid, which is important because it provides the lipids that coat the outer layer of the skin, keeping the body from losing water and energy, which would retard growth, the scientist said.

But skin function seems to be more complicated than that. These itchy mice had plenty of linoleic acid. They just couldn't convert it to arachidonic acid because the gene to make the necessary enzyme had been knocked out, he noted.

Arachidonic acid is also essential to the production of prostaglandins, compounds that can lead to inflammatory reactions and are important to immune function. Common painkillers like aspirin and ibuprofen work by inhibiting the conversion of arachidonic acid to prostaglandins.

"We usually think of inflammation as a bad thing, but in this case, prostaglandins prevented dermatitis, which is an inflammatory reaction. We measured prostaglandin levels in the animals' skin, and when we fed arachidonic acid to the knockout mice, they resumed making these important chemical compounds," he said.

Nakamura cautioned that there are still things they don't understand about the function of this omega-6 fatty acid. "This new knowledge is a starting point in understanding the mechanisms that are involved, and we need to do more research at the cellular level."


'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois at Urbana-Champaign
Source:Eurekalert

Related biology news :

1. Study: diabetic neuropathy costs billions per year in lost work time
2. Study: Fountain of youth for your heart?
3. First-ever study: lack of critical lubricant causes wear in joints
4. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
5. Study: weight-loss tips differ in African-American, mainstream magazines
6. Smithsonian study: Sediment prediction tools off the mark
7. Mouse study: When it comes to living longer, its better to go hungry than go running
8. Geisinger study: Inflammatory disease causes blindness
9. Stanford study: Bioenergy potential of reviving abandoned agricultural land
10. U-M study: Herceptin targets breast cancer stem cells
11. Study: Future snowmelt in West twice as early as expected; threatens ecosystems and water reserves
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2, 2017 Summary This report provides ... its partnering interests and activities since 2010. ... Read the full report: ... since 2010 report provides an in-depth insight into the partnering ... On demand company reports are prepared upon purchase ...
(Date:2/28/2017)... 2017   Acuant , a leading provider of ... enhancements to new and core technologies building upon the ... mobile and desktop Acuant FRM TM facial recognition ... real time manual review of identity documents by accredited ... fastest and most accurate capture software to streamline workflows ...
(Date:2/24/2017)... , Feb. 24, 2017  EyeLock LLC, a leader ... its elite iris biometric solution on the latest ... LTE at Mobile World Congress 2017 (February ... Booth in Hall 3, Stand 3E10. ... Qualcomm Haven™ security platform—a combination of hardware, ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... (PRWEB) , ... March 29, 2017 , ... Bactana Animal ... hormones in the world’s food supply through enhancement of the gut microbiota, today announced ... included Connecticut Innovations , New York-based Sustainable Income Capital Management, LLC and a ...
(Date:3/29/2017)... and NEWARK, Del. , March 29, ... regenerative medicine company, and W. L. Gore ... today announced a collaborative research agreement whereby the two ... therapy delivery device technologies that provide protection from immune ... ViaCyte has been developing innovative stem cell-derived cell replacement ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ -  GeneNews Limited (TSX:GEN) ... BreastSentry™ , a new risk stratification test for breast cancer, ... Innovative Diagnostics Laboratory ("IDL"). BreastSentry incorporates a blood-based biomarker test ... lifetime risk for developing breast cancer.   ... BreastSentry measures the fasting ...
(Date:3/29/2017)... The Global Microfluidic Chips Market by Manufacturers, Countries, Type ... study on the existing state of the global Microfluidic Chips industry ... and Asia-Pacific , South ... Africa . ... Browse 172 Tables and Figures, 13 Major Company Profiles, spread ...
Breaking Biology Technology: