Navigation Links
U of I scientists develop tool to trace metabolism of cancer-fighting tomato compounds
Date:11/29/2010

URBANA The University of Illinois scientists who linked eating tomatoes with a reduced risk of prostate cancer have developed a tool that will help them trace the metabolism of tomato carotenoids in the human body. And they've secured funding from the National Institutes of Health to do it.

"Scientists believe that carotenoidsthe pigments that give the red, yellow, and orange colors to some fruits and vegetablesprovide the cancer-preventive benefits in tomatoes, but we don't know exactly how it happens," said John W. Erdman, a U of I professor of human nutrition.

The researchers will use isotopic labeling of three tomato carotenoids with heavier carbon atoms than are commonly seen in nature, which will allow tracking of the tomato components' absorption and metabolism in the body, he said.

"We have two questions we'd like to answer. First, are the carotenoids themselves bioactive, or are their metabolic or oxidative products responsible for their benefits? Second, is lycopene alone responsible for the tomato's benefits, or are other carotenoids also important?" he said.

Previous Erdman animal studies have shown that whole tomato powder, which contains all of the fruit's nutritional components, is more effective against prostate cancer than lycopene alone.

"Lycopene, which gives the fruit its red color, has received a lot of attentionit's even advertised as an ingredient in multivitamin supplements, but two little-known colorless carotenoids, phytoene and phytofluene, probably also have benefits," said Nancy Engelmann, a doctoral student in Erdman's laboratory who helped to develop the new method.

Engelmann learned to optimize the amount of carotenoids in tomato cell cultures by treating already high-achieving tomato varieties with two plant enzyme blockers. The best performers were then chosen for culturing and carbon-13 labeling, she said.

The scientists grew tomato cells with non-radioactive carbon-13 sugars, yielding carbon molecules that are heavier than the 12-carbon molecules that exist elsewhere, Erdman said.

"These heavy carbon molecules are then incorporated into the carotenoids in the tomato cell cultures. The result is that researchers will be able to track the activity of lycopene, phytoene, and phytofluene and their metabolites," he said.

Thanks to NIH funding, U of I researchers and colleagues at The Ohio State University are preparing to use this new tool to study carotenoid metabolism in humans.

"It's exciting that we now have the means to pull off this human study. It's work that should move us forward in the fight against prostate cancer," he said.


'/>"/>

Contact: Phyllis Picklesimer
p-pickle@illinois.edu
217-244-2827
University of Illinois College of Agricultural, Consumer and Environmental Sciences
Source:Eurekalert

Related biology news :

1. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
2. Scientists identify novel inhibitor of human microRNA
3. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
4. MU scientists go green with gold, distribute environmentally friendly nanoparticles
5. Scientists identify gene that may contribute to improved rice yield
6. Scientists discover why a mothers high-fat diet contributes to obesity in her children
7. MU scientists see how HIV matures into an infection
8. Earth scientists keep an eye on Texas
9. Thinking it through: Scientists call for policy to guide biofuels industry toward sustainability
10. Scientists identify a molecule that coordinates the movement of cells
11. Scientists Find new migratory patterns for Mediterranean and Western Atlantic bluefin tuna
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... LIVERMORE, Calif. , Feb. 3, 2016 ... Police Department in Missouri ... of license plate reader (LPR) data from Vigilant Solutions. ... a hit-and-run case in which the victim was walking out ... a parking space next to his vehicle, striking his ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 ... healthcare facilities are primarily focused on medical ... that measure point-of-care parameters. Wearable devices that ... a user,s freedom of movement are being ... sensors for human biomedical signal acquisition coupled ...
(Date:2/2/2016)... 2016 Checkpoint Inhibitors for Cancer – ... Are you interested in the future of cancer ... inhibitors. Visiongain,s report gives those predictions to 2026 ... level. Avoid falling behind in data or ... revenues those emerging cancer therapies can achieve. There ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Spectra BioPharma Selling ... (CSO) that provides biopharma companies the experience, expertise, ... and deploy outsourced sales teams. Created in concert ... addresses both the strategic and tactical needs of ... sales solutions through both personal and non-personal promotion. ...
(Date:2/11/2016)... Florida , February 11, 2016 ... PositiveID Corporation ("PositiveID" or "Company") (OTCQB: PSID), a ... announced today that its Thermomedics subsidiary, which markets ... on its growth plan in January 2016, including ... distributors, increasing sequential monthly sales growth, and establishing ...
(Date:2/11/2016)... ... February 11, 2016 , ... Global ... treatment clinic in Quito, Ecuador. The new facility will provide advanced protocols and ... from around the world. , The new GSCG clinic is headed by ...
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal ... its proprietary NeXosome® technology for early warning of ... its most recent study by Dr. Thomas ... the Society for Maternal Fetal Medicine,s (SMFM) annual meeting ... 1-6 th , 2016.  The presentation reported initial ...
Breaking Biology Technology: