Navigation Links
U of Alberta researcher discovers potential cancer therapy target
Date:2/14/2011

One of the most important genes in the human genome is called p53 and its function is to suppress tumours, according to Roger Leng, a researcher in the Faculty of Medicine & Dentistry. Leng has discovered the mechanism by which p53 is inactivated in cancerous cells, allowing tumours to grow.

"Successful completion of the proposed experiments could lead to novel anti-cancer therapies that could potentially improve the prognosis for cancer patients and reduce the public health burden from cancer," said Leng.

It has long been known by scientists that another protein, MDM2, lowers p53 in the body, but in cancerous cells p53 is inactivated in more than 50 per cent of all human tumours. MDM2 does not have the ability to functionally silence the tumour suppressing protein on its own, leaving scientists wondering what molecule in the body is helping MDM2 to nearly eliminate p53 in cancerous cells.

Leng's lab has answered that question and the culprit is called UBE4B. Leng made the discovery because he found that UBE4B binds with both p53 and MDM2. From there his lab was able to discover the relationship between the proteins.

Paired with MDM2, also known as HDM2 in humans, the two proteins completely degrade p53 in a laboratory model. This is a process known as poly-ubiquitination, which means a specific protein completely disappears in a cell.

They also did experiments on cancerous human brain tissue and found the same results.

"They have the same function," said Leng. "The idea now is you can target UBE4B and MDM2 won't function."

This discovery landed Leng in the pages of one of the highest-impact scientific journals, Nature Medicine. His work was published online on Sunday, Feb. 13.

Now, the Alberta Heritage Foundation for Medical Research Scholar and Canadian Institutes of Health Research funded scientist wants to further understand the mechanisms by which UBE4B functions.

"We want to understand how it regulates MDM2," said Leng. "We also want to see, if you get DNA damage, what happens in UBE4B and p53."

All of which could provide answers which eventually lead to a pharmacological target for cancer therapy.


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-399-7505
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related biology news :

1. U of Alberta researchers discover important mechanism in fighting infection
2. U Alberta-led team studies T cell activation with nanoparticles
3. U Alberta find could shield humans from influenza virus
4. U of Alberta researchers find mechanism that could prevent or treat deadly peroxisome diseases
5. U Alberta researcher in same group as Darwin and Hawking
6. New dinosaur species possible in Northwestern Alberta
7. A new dinosaur species, Pachyrhinosaur lakustai, unveiled from Pipestone Creek, Alberta, Canada
8. Boston University School of Medicine researchers receive NIMH brain awards
9. Just in time for Valentines Day: UNC researchers identify a gene critical for heart function
10. Johns Hopkins researchers capture jumping genes
11. The brain knows what the nose smells, but how? Stanford researchers trace the answer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2, 2017 Summary This report ... Merck KGaA and its partnering interests and activities since ... Description The Partnering Deals and Alliance since 2010 ... of one of the world,s leading life sciences companies. ... purchase to ensure inclusion of the most up to ...
(Date:2/28/2017)... --  Acuant , a leading provider of data capture ... new and core technologies building upon the acquisition of ... desktop Acuant FRM TM facial recognition and match ... manual review of identity documents by accredited professionals. ... most accurate capture software to streamline workflows by securely ...
(Date:2/26/2017)... 2017  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announces the appointment ... "Too often, too many offenders return to ... are trying to tackle this ongoing problem and ... family members. While significant steps are underway, Securus continues ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... The new research portal will give ... reports on Valero Energy , offering extensive market research ... ... (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO) The latest trend gaining ... Ethanol today, even though touted as a green alternative to ...
(Date:3/27/2017)... 27, 2017  Trovagene, Inc. (NASDAQ: TROV), a precision ... Officer, Bill Welch , will be presenting at ... 9:00 AM EDT at the Essex House in ... Chief Scientific Officer, Mark Erlander , Ph.D., will ... conference.   The presentation will be webcast live ...
(Date:3/24/2017)... MARIETTA, Ga. , March 24, 2017 ... and biopharmaceutical company utilizing human placental tissue allografts and ... therapies for multiple sectors of healthcare, announced today  that ... New York , NY.  Parker H. ... , Chief Financial Officer, Christopher M. Cashman , ...
(Date:3/24/2017)... March 24, 2017 Sinovac Biotech Ltd. ("Sinovac" or the ... China , today announced that its board of directors ... of the plan from March 27, 2017 to March 27, 2018. The ... About Sinovac Biotech Ltd. ... Sinovac Biotech Ltd. is a ...
Breaking Biology Technology: