Navigation Links
U of A researchers can predict heart transplant patient's health earlier
Date:11/10/2010

Michael Mengel, a pathology researcher with the Faculty of Medicine & Dentistry, has found a new way to analyze biopsies from heart transplant patients by looking at their genes. This allows him to make an early prediction whether the transplant is working.

This is extremely important in heart transplant patients because a successful outcome depends completely on doing a biopsy of the heart tissue and prescribing treatments if necessary. In other organs transplants, doctors can use other measurements.

It's hoped the new technology and process developed in the Faculty of Medicine & Dentistry will become a standard of care worldwide, and improve patient care within the next three to five years, says Mengel.

Using what is called gene chip technology, Mengel can look at all 54,000 human genes of a heart transplant biopsy. Then, by using software algorithms developed by the team at the faculty's Alberta Transplant Applied Genomics Centre, he can reduce them to a dozen single numbers, all of which are necessary to interpret what is happening and make a diagnosis.

"This system of molecular annotation to predict prognosis is better than anything else available currently," said Mengel. "We get more information out of the tissue than we were able to before we could read all the genes."

The current standard of care is for pathologists to use a microscope and assess single cells in the diseased tissue. The problem is, pathologists can see tissue lesions but can't see finer details like the difference between tissue injury and rejection.

With Mengel's new approach they can go beyond the microscope and assess changes in the molecules in a tissue. This helps pathologists tell the difference between certain disease processes. Based on such improved diagnosis, physicians can start appropriate treatment earlier, further improving the patient's long-term outcome after getting a heart transplant.

"Molecules also give mechanistic insight and can help to discover new drug targets," adds Mengel.

The group is getting close to having this used worldwide in clinics. The next trial, which will begin in 2011, will be an international multi-centre validation trial. They'll send the new type of biopsy results to transplant physicians across the United States, Germany, Spain and the United Kingdom and get feedback on the process and how efficient and useful the data is in a clinical setting.

He's optimistic that in a few years, pathologists and transplant doctors elsewhere will start using the process he and his team have developed. "That (time frame) sounds long for individual patients, but in terms of device development, in the time frames the health-care industry usually calculates things, it is a very short period because they usually think in terms of 10 or 15 years," notes Mengel. "It's not more research; it's already application in real patients."

The Alberta Transplant Applied Genomics Centre in the Faculty of Medicine & Dentistry is leading the world in this field. The centre's director, Phil Halloran, has worked in transplant immunology for more than 30 years. Recently this renowned group published work with gene chips and kidney transplants, showing the molecules could better predict outcome than any other clinical or pathological parameter.

The group's recent work in cardiac transplant patients is published in American Journal of Transplantation.


'/>"/>

Contact: Quinn Phillips
quinn.phillips@ualberta.ca
780-248-2048
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Related biology news :

1. UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer
2. Jefferson researchers receive W.W. Smith Charitable Trust
3. Studying the metabolome of smokers, Lombardi researchers find early signs of damage
4. Johns Hopkins researchers reshape basic understanding of cell division
5. Researchers unlock the secret of bacterias immune system
6. Missouri Botanical Garden researchers discover 8 new species in Boliva national parks
7. University of Illinois researchers discover potential new virus in switchgrass
8. NYU Courant researchers develop algebraic model to monitor cellular change
9. Researchers developing real-time electronic monitoring for coastal waters
10. Researchers could use plants light switch to control cells
11. Researchers engineer miniature human livers in the lab
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... Florida , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange ... potential users of its soon to be launched online ... ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential ... use of DNA technology to an industry that is ...
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
(Date:3/21/2016)... WAKEFIELD, Massachusetts , March 22, 2016 ... and facial recognition with passcodes for superior security ... MESG ), a leading provider of secure digital communications ... pilot their biometric technology and offer enterprise customers, particularly ... provide secure facial recognition and voice authentication within a ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is ... has received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval ... Bob Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods ...
Breaking Biology Technology: