Navigation Links
U of A medical researchers ID genetic marker for sporadic breast cancer
Date:5/28/2013

Medical researchers at the University of Alberta have pinpointed a genetic marker for sporadic breast cancer one of a handful identified to date in Caucasians.

Researchers have identified many genetic markers for familial breast cancers, but not for sporadic breast cancer which accounts for 80 per cent of all cases. Sambasivarao Damaraju, a professor with the Faculty of Medicine & Dentistry and a researcher at the Cross Cancer Institute, worked with his team to scan the DNA of about 7,200 Alberta women, including those who have had sporadic breast cancer and those who have not had cancer. Their genomes were scanned from DNA isolated from blood.

The results? Women who had sporadic breast cancer frequently had a genetic marker on chromosome 4 a marker that has never been associated with familial breast cancer cases.

"The frequency of this marker occurring was statistically significant," says Damaraju, who works in the Department of Laboratory Medicine & Pathology. "Genetic factors that predispose women to breast cancer is a subject of intense investigation in the research world. While 60 to 70 genetic risk factors have been identified for familial breast cancer, we don't know much about the genetic risk factors for sporadic breast cancer. So this finding is exciting, and shows us more research is needed in this area."

The team's findings were recently published in the peer-reviewed journal, PLoS One. Damaraju noted the team, which included co-author John Mackey and PhD student Yadav Sapkota, was multi-disciplinary, including basic scientists, medical oncologists, biostatisticians and epidemiologists. He also acknowledged the initial contributions to this work from previous trainees, Malinee Sridharan and Badan S. Sehrawat. Overall, he collaborated with colleagues from the U of A's School of Public Health, the Department of Oncology, and the Department of Agricultural, Food and Nutritional Sciences, as well as colleagues from the Cross C
'/>"/>

Contact: Raquel Maurier
rmaurier@ualberta.ca
780-492-5986
University of Alberta Faculty of Medicine & Dentistry
Source:Eurekalert

Page: 1 2

Related biology news :

1. Alnylam and UMass Medical School announce Tuschl I patent upheld in European opposition proceedings
2. Miniature pressure sensors for medical touch
3. Research!America says house funding levels for FY13 could undermine medical progress
4. Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship
5. Medical device, health professionals attend first national conference on value-driven engineering
6. Ultrasensitive biosensor promising for medical diagnostics
7. UH Case Medical Center, CardioKinetix reveal promising data for treatment for heart failure
8. Tufts Medical Center researchers finds marker in premies saliva predicts readiness to feed by mouth
9. CDS Monarch Deploys DigitalPersona Strong Authentication Solutions for Secure Access to Electronic Medical Records
10. Nuisance seaweed found to produce compounds with biomedical potential
11. MADRID-MIT M+Vision Consortium hosts Biomedical Innovation Conference 2012
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... household and industrial products are in the environment – ... of them, scientists have yet to determine whether they ... toward doing that by estimating which substances people are ... in the ACS journal Environmental Science & Technology ... the risks to human health of any given substance ...
(Date:10/29/2014)... Mich. – As bodies decompose, their types and ... clues they provide could mean the difference between ... Michigan State University is using a more than ... Detroit death-scene investigators examine these changing populations. The ... geographical location of death, gender, race, socioeconomic relations ...
(Date:10/29/2014)... new research potential of the Barcode of Life ... the Biodiversity Data Journal (BDJ) ... and imported these into a human-readable text developed in ... Data were used to study the species distributions of ... subfamily. , BOLD is originally designed to support the ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... a type of contaminant in the atmosphere, considered very ... and visibility. Chemist Ms Ainhoa Inza studied the presence ... the Basque Country (CAV-EAE); concretely, the type known as ... micras in diameter. Amongst other things, the researcher compared ...
... Rochester Institute of Technology has been awarded a ... Standards and Technology to assist in construction of ... university,s Golisano Institute for Sustainability. The building will ... transfer, education and outreach and provide a state-of-the-art ...
... University of Wellington, New Zealand, crouched low to the ground and ... plant cushion, then sat back waiting to see if something would ... have thought so, but Pufal was trying to find potential plant ... Although the ability to move is typically thought to ...
Cached Biology News:Thesis studies atmospheric PM contaminant in the Basque Autonomous Community 2RIT receives federal grant to construct new sustainability research facility 2RIT receives federal grant to construct new sustainability research facility 3RIT receives federal grant to construct new sustainability research facility 4Plants that move: How a New Zealand species disperses seeds in a high alpine, wet environment 2Plants that move: How a New Zealand species disperses seeds in a high alpine, wet environment 3
(Date:10/30/2014)... October 30, 2014 Spartan Bioscience announced ... RX CYP2C19 System . It detects CYP2C19 genetic mutations ... swab. , The Spartan RX CYP2C19 System is the ... been approved in Canada. Due to the system’s ease ... be used by healthcare professionals such as doctors, nurses, ...
(Date:10/30/2014)... October 30, 2014 Avure Technologies celebrates a ... the newest member of its fleet of high volume High ... an anniversary as we return to PackExpo this year, which ... in Las Vegas,” said Jeff Williams, CEO at Avure. “Sales ... we’re pleased to be meeting the challenges of market demand ...
(Date:10/30/2014)... CARLSBAD, Calif. , Oct. 30, 2014 Isis ... antisense therapeutics, today announced that management will present a company ... 2014 at 8:30 a.m. ET in Boston, MA. ... will be available on the "Investors & Media" section of ... available on the Isis website within 48 hours and will ...
(Date:10/30/2014)... RIDGE, N.J. , Oct. 30, 2014  Regado ... that it will hold a conference call and live ... a.m. EST to discuss its third quarter 2014 financial ... the conference call by dialing (888) 347-1165 for domestic ... call will be webcast live under the investor relations ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 2In High Demand: New High Pressure Processing (HPP) System with Maximum Throughput Drives Strong Sales 3Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2
... HOBOKEN, N.J. , Aug. 2 Octapharma USA ... Grants Program is the Rush Hemophilia & Thrombophilia Center at ... pre-clinical research focused on human protein therapies in hematology, immune therapy, intensive care ... ...
... CLEVELAND , Aug. 2 DATATRAK ... focused on global eClinical solutions for the clinical trials ... selected DATATRAK,s eClinical™ platform for a cardiovascular clinical study ... . Reaping the benefits of a unified platform, DAIICHI ...
... enough. Now imagine 15,000 of them. A Northwestern ... 15,000 identical skylines with tiny beams of light using ... Details of the new method, which could do for ... and information transfer, will be published Aug. 1 by ...
Cached Biology Technology:Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 2Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 3Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 4Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 5Octapharma Grants Program Awards First Research Grant to Rush University Medical Center 6DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 2DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 3DAIICHI SANKYO EUROPE GmbH Selects DATATRAK eClinical™ for Pan-European Systolic Hypertension Study 415,000 beams of light 215,000 beams of light 3
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
... cells (HSC) are well-characterized tissue-specific stem cells ... responsible for the life-long maintenance of the ... reside in adult bone marrow where hematopoiesis ... be found in cord blood, fetal liver, ...
Biology Products: