Navigation Links
U-M researchers find potential new way to fight sepsis

ANN ARBOR, Mich. By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.

Scientists at the University of Michigan Health System looked at microRNA, a type of RNA that does not code for a protein itself but that can regulate the expression of other genes and proteins. They found that by attacking the right microRNA they could influence a key trigger of inflammatory diseases such as sepsis.

Traditionally, researchers have gone after a bigger target, attempting to find compounds that directly control inflammatory triggers such as interleukin 6, or IL-6.

"If you can connect all the dots, you can target a single microRNA and impact an inflammatory process like sepsis. But given the role of IL-6 in other diseases, we think this might have broader implications than sepsis for diseases where IL-6 plays a role," says study author Pavan Reddy, M.D., associate professor of hematology/oncology at the U-M Medical School.

Results of the study appear in the June 9 issue of Blood.

The researchers looked specifically at dendritic cells, specialized types of cells that are considered the first-responders in an immune response. Dendritic cells are also amongst the most important cells that turn on other immune cells. Using bioinformatics tools, the researchers identified two microRNAs within the dendritic cells that seemed most predominant in regulating IL-6. One, called miR-142-3p, was shown to have a direct link to regulating IL-6, and only IL-6.

The researchers were then able to specifically target miR-142-3p that would block it from influencing IL-6. They found in mice that doing this reduced deaths from sepsis.

"We showed that microRNAs have unique expression profiles in dendritic cells and that miR-142-3p has an important role in dendritic cell response. This suggests targeting microRNAs may be a novel strategy for treating sepsis," says lead study author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.

The researchers believe this approach will also hold potential for other inflammatory diseases such as juvenile rheumatoid arthritis, inflammatory bowel disease and graft-vs.-host disease, a frequent complication of bone marrow transplant. More research is needed before any treatments become available to patients.


Contact: Nicole Fawcett
University of Michigan Health System

Related biology news :

1. Penn researchers show new evidence of genetic arms race against malaria
2. Penn researchers develop biological circuit components, new microscope technique for measuring them
3. Researchers discover potential cause of chronic painful skin
4. University of Iowa researchers identify caffeine-consuming bacterium
5. USC researchers discover genetic mutation causing excessive hair growth
6. Eating dirt can be good for the belly, researchers find
7. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
8. UNH researchers receive grant for pioneering carbon cycle model
9. Penn researchers help nanoscale engineers choose self-assembling proteins
10. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
11. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
Post Your Comments:
Related Image:
U-M researchers find potential new way to fight sepsis
(Date:11/20/2015)... 2015 NXTD ) ("NXT-ID" or ... growing mobile commerce market and creator of the Wocket® ... was recently interviewed on The RedChip Money Report ... weekend on Bloomberg Europe , Bloomberg Asia, Bloomberg ... NXTD ) ("NXT-ID" or the "Company"), a biometric ...
(Date:11/18/2015)... , November 18, 2015 ... published a new market report titled  Gesture Recognition Market ... Forecast, 2015 - 2021. According to the report, the global gesture ... is anticipated to reach US$29.1 bn by 2021, at ... North America dominated the global ...
(Date:11/17/2015)... Nov. 17, 2015 Pressure BioSciences, Inc. (OTCQB: ... development and sale of broadly enabling, pressure cycling technology ... industry, today announced it has received gross proceeds of ... Private Placement (the "Offering"), increasing the total amount raised ... more additional closings are expected in the near future. ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... , ... November 27, 2015 , ... ... that includes over 2,000 technical presentations offered in symposia, oral sessions, workshops, ... applied spectroscopy, covers a wide range of applications such as, but not limited ...
(Date:11/25/2015)... Nov. 25, 2015  PharmAthene, Inc. (NYSE MKT: PIP) ... a stockholder rights plan (Rights Plan) in an effort ... carryforwards (NOLs) under Section 382 of the Internal Revenue ... PharmAthene,s use of its NOLs could be substantially ... defined in Section 382 of the Code. In general, ...
(Date:11/25/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS; TSX: AEZ) ... remain fundamentally strong and highlights the following developments: ... DSMB recommendation to continue the ZoptEC Phase 3 ... final interim efficacy and safety data , ... with heavily pretreated castration- and Taxane-resistant prostate cancer ...
(Date:11/24/2015)... 2015  Asia-Pacific (APAC) holds the third-largest share ... The trend of outsourcing to low-cost locations is ... volume share for the region in the short ... in the CRO industry will improve. ... ), finds that the market earned revenues ...
Breaking Biology Technology: