Navigation Links
U-M researchers find potential new way to fight sepsis
Date:6/10/2011

ANN ARBOR, Mich. By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.

Scientists at the University of Michigan Health System looked at microRNA, a type of RNA that does not code for a protein itself but that can regulate the expression of other genes and proteins. They found that by attacking the right microRNA they could influence a key trigger of inflammatory diseases such as sepsis.

Traditionally, researchers have gone after a bigger target, attempting to find compounds that directly control inflammatory triggers such as interleukin 6, or IL-6.

"If you can connect all the dots, you can target a single microRNA and impact an inflammatory process like sepsis. But given the role of IL-6 in other diseases, we think this might have broader implications than sepsis for diseases where IL-6 plays a role," says study author Pavan Reddy, M.D., associate professor of hematology/oncology at the U-M Medical School.

Results of the study appear in the June 9 issue of Blood.

The researchers looked specifically at dendritic cells, specialized types of cells that are considered the first-responders in an immune response. Dendritic cells are also amongst the most important cells that turn on other immune cells. Using bioinformatics tools, the researchers identified two microRNAs within the dendritic cells that seemed most predominant in regulating IL-6. One, called miR-142-3p, was shown to have a direct link to regulating IL-6, and only IL-6.

The researchers were then able to specifically target miR-142-3p that would block it from influencing IL-6. They found in mice that doing this reduced deaths from sepsis.

"We showed that microRNAs have unique expression profiles in dendritic cells and that miR-142-3p has an important role in dendritic cell response. This suggests targeting microRNAs may be a novel strategy for treating sepsis," says lead study author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.

The researchers believe this approach will also hold potential for other inflammatory diseases such as juvenile rheumatoid arthritis, inflammatory bowel disease and graft-vs.-host disease, a frequent complication of bone marrow transplant. More research is needed before any treatments become available to patients.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related biology news :

1. Penn researchers show new evidence of genetic arms race against malaria
2. Penn researchers develop biological circuit components, new microscope technique for measuring them
3. Researchers discover potential cause of chronic painful skin
4. University of Iowa researchers identify caffeine-consuming bacterium
5. USC researchers discover genetic mutation causing excessive hair growth
6. Eating dirt can be good for the belly, researchers find
7. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
8. UNH researchers receive grant for pioneering carbon cycle model
9. Penn researchers help nanoscale engineers choose self-assembling proteins
10. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
11. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers find potential new way to fight sepsis
(Date:5/20/2016)... 2016  VoiceIt is excited to announce its ... By working together, VoiceIt and VoicePass will ... VoicePass take slightly different approaches to voice biometrics, ... and usability. ... partnership. "This marketing and technology partnership ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:5/12/2016)... 12, 2016 WearablesResearch.com , a brand ... overview results from the Q1 wave of its quarterly ... was consumers, receptivity to a program where they would ... health insurance company. "We were surprised to ... Michael LaColla , CEO of Troubadour Research, "primarily ...
Breaking Biology News(10 mins):
(Date:5/24/2016)... ... May 24, 2016 , ... Last week, Callan Capital, an integrated wealth ... held The Future of San Diego Life Science event at the Estancia La Jolla ... attended the event with speakers Dr. Rich Heyman, former CEO of Aragon and Seragon, ...
(Date:5/24/2016)... Rockville, Maryland (PRWEB) , ... May 24, 2016 ... ... introduction of a newly re-branded identity. The new Media Cybernetics corporate branding reflects ... the world of imaging and image analysis. The re-branding components include a crisp, ...
(Date:5/23/2016)... San Antonio, Texas (PRWEB) , ... May 23, 2016 , ... The need for blood ... infographic released this week by the South Texas Blood & Tissue Center, blood donations are ... more than 30 years, and they are down 21 percent in South Texas in the ...
(Date:5/23/2016)... , ... May 23, 2016 , ... ... Will Drive Precision Farming in 2017 and Beyond. The paper outlines the key ... the precision ag industry. , “We’ve witnessed a lot of highs and lows ...
Breaking Biology Technology: