Navigation Links
U-M researchers find potential new way to fight sepsis
Date:6/10/2011

ANN ARBOR, Mich. By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.

Scientists at the University of Michigan Health System looked at microRNA, a type of RNA that does not code for a protein itself but that can regulate the expression of other genes and proteins. They found that by attacking the right microRNA they could influence a key trigger of inflammatory diseases such as sepsis.

Traditionally, researchers have gone after a bigger target, attempting to find compounds that directly control inflammatory triggers such as interleukin 6, or IL-6.

"If you can connect all the dots, you can target a single microRNA and impact an inflammatory process like sepsis. But given the role of IL-6 in other diseases, we think this might have broader implications than sepsis for diseases where IL-6 plays a role," says study author Pavan Reddy, M.D., associate professor of hematology/oncology at the U-M Medical School.

Results of the study appear in the June 9 issue of Blood.

The researchers looked specifically at dendritic cells, specialized types of cells that are considered the first-responders in an immune response. Dendritic cells are also amongst the most important cells that turn on other immune cells. Using bioinformatics tools, the researchers identified two microRNAs within the dendritic cells that seemed most predominant in regulating IL-6. One, called miR-142-3p, was shown to have a direct link to regulating IL-6, and only IL-6.

The researchers were then able to specifically target miR-142-3p that would block it from influencing IL-6. They found in mice that doing this reduced deaths from sepsis.

"We showed that microRNAs have unique expression profiles in dendritic cells and that miR-142-3p has an important role in dendritic cell response. This suggests targeting microRNAs may be a novel strategy for treating sepsis," says lead study author Yaping Sun, M.D., Ph.D., internal medicine research investigator at the U-M Medical School.

The researchers believe this approach will also hold potential for other inflammatory diseases such as juvenile rheumatoid arthritis, inflammatory bowel disease and graft-vs.-host disease, a frequent complication of bone marrow transplant. More research is needed before any treatments become available to patients.


'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Related biology news :

1. Penn researchers show new evidence of genetic arms race against malaria
2. Penn researchers develop biological circuit components, new microscope technique for measuring them
3. Researchers discover potential cause of chronic painful skin
4. University of Iowa researchers identify caffeine-consuming bacterium
5. USC researchers discover genetic mutation causing excessive hair growth
6. Eating dirt can be good for the belly, researchers find
7. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
8. UNH researchers receive grant for pioneering carbon cycle model
9. Penn researchers help nanoscale engineers choose self-assembling proteins
10. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
11. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers find potential new way to fight sepsis
(Date:3/23/2017)... , Mar. 23, 2017 Research and ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 8.8% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/22/2017)... Calif. , March 21, 2017 ... analytics company serving law enforcement agencies, announced today the ... as director of public safety business development. ... diversified law enforcement experience, including a focus on the ... In his most recent position, Mr. Sheridan served as ...
(Date:3/16/2017)... HANOVER, Germany , March 16, 2017 CeBIT 2017 - Against ... Continue Reading ... Used combined in one project, multi-biometric solutions ... ... Identification Systems) ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... firm for the life sciences and healthcare industries, is pleased to announce Holger ... new established USDM subsidiary “USDM Europe GmbH” based in Germany. , Braemer is ...
(Date:4/20/2017)... April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. (TSX: PLI) ... at the International Liver Congress ("ILC") 2017 of the European ... Amsterdam on the positive effects of PBI-4050 ... of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of R&D Pre-clinical ...
(Date:4/20/2017)... ... April 20, 2017 , ... ... unique intellectual property (IP) sharing and commercialization model. , The Center for Advancing ... main component of this effort is bringing the IP to the attention of ...
(Date:4/20/2017)... 2017 For today, Stock-Callers.com redirects investors, ... development and clinical research aimed at treating diseases and medical ... Keryx Biopharmaceuticals Inc. (NASDAQ: KERX), Kite Pharma Inc. (NASDAQ: KITE), ... can access our complimentary research reports on these stocks now ... http://stock-callers.com/registration ...
Breaking Biology Technology: