Navigation Links
U-M researchers find potential new way to fight sepsis
Date:6/10/2011

ANN ARBOR, Mich. By digging a little deeper, researchers may have found a potential target for reversing the deadly blood infection sepsis.

Scientists at the University of Michigan Health System looked at microRNA, a type of RNA that does not code for a protein itself but that can regulate the expression of other genes and proteins. They found that by attacking the right microRNA they could influence a key trigger of inflammatory diseases such as sepsis.

Traditionally, researchers have gone after a bigger target, attempting to find compounds that directly control inflammatory triggers such as interleukin 6, or IL-6.

"If you can connect all the dots, you can target a single microRNA and impact an inflammatory process like sepsis. But given the role of IL-6 in other diseases, we think this might have broader implications than sepsis for diseases where IL-6 plays a role," says study author Pavan Reddy, M.D., associate professor of hematology/oncology at the U-M Medical School.

Results of the study appear in the June 9 issue of Blood.

The researchers looked specifically at dendritic cells, specialized types of cells that are considered the first-responders in an immune response. Dendritic cells are also amongst the most important cells that turn on other immune cells. Using bioinformatics tools, the researchers identified two microRNAs within the dendritic cells that seemed most predominant in regulating IL-6. One, called miR-142-3p, was shown to have a direct link to regulating IL-6, and only IL-6.

The researchers were then able to specifically target miR-142-3p that would block it from influencing IL-6. They found in mice that doing this reduced deaths from sepsis.

"We showed that microRNAs have unique expression profiles in dendritic cells and that miR-142-3p has an important role in dendritic cell response. This suggests targeting microRNAs may be a novel strategy for treating sepsis," s
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Penn researchers show new evidence of genetic arms race against malaria
2. Penn researchers develop biological circuit components, new microscope technique for measuring them
3. Researchers discover potential cause of chronic painful skin
4. University of Iowa researchers identify caffeine-consuming bacterium
5. USC researchers discover genetic mutation causing excessive hair growth
6. Eating dirt can be good for the belly, researchers find
7. Caltech researchers build largest biochemical circuit out of small synthetic DNA molecules
8. UNH researchers receive grant for pioneering carbon cycle model
9. Penn researchers help nanoscale engineers choose self-assembling proteins
10. Researchers from the Viikki Biocenter discover how plants control the formation of wood cells
11. Researchers solve mammoth evolutionary puzzle: The woollies werent picky, happy to interbreed
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers find potential new way to fight sepsis
(Date:8/29/2014)... them, fold them: modern materials that are light, flexible ... artificial skin or electronic paper. , Making such concepts ... a new way of working with copper nanowires and ... , Previous success in the field of ultra-lightweight "aerogel ... gold and silver nanowires. , By turning instead ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... available in German . ... its name to a striking pattern of blue stripes alternating ... reflective silvery cells, and yellow cells emerge during growth in ... a multilayered mosaic to compose the characteristic colour pattern. ... have to interact to form proper stripes, the embryonic origin ...
Breaking Biology News(10 mins):Copper shines as flexible conductor 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... front-line defense don’t necessarily rest quietly until invading bacteria ... them to action, as previously thought. In a new ... bacteria can barge inside these guard cells and independently ... published online ahead of print in the April issue ...
... Rothberg of the University of Rochester Chemistry Department received a ... recent discovery by Huixiang Li, a research associate in his ... and make sure we're drinking clean water and eating uncontaminated ... help forensics labs identify criminals, test ponds and pools before ...
... Hypotheses, an Elsevier publication, has announced the winner of ... by Judith Rich-Harris, author of The Nurture Assumption and ... selection process in the evolution of human hairlessness and ... of the journal. The £1,000 prize, launched in 2004, ...
Cached Biology News:Microbes start immune response by sneaking inside cells 2Rapid, Low-Cost DNA Testing 2Rapid, Low-Cost DNA Testing 3Why aren't humans furry? Stone-Age moms could be the answer 2
(Date:8/28/2014)... DIEGO, California, USA (PRWEB) August 28, 2014 ... the Department of Physics and Optical Science and Director ... the University of North Carolina at Charlotte, and co-founder ... been elected to serve as the 2015 Vice President ... , SPIE 2014 President Philip Stahl announced recent election ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
(Date:8/28/2014)... YORK , Aug. 28, ... that a new market research ... catalogue: Whole Exome ... Kits (Library Preparation, Target Enrichment), ... (Sequencing by Synthesis), by Application ...
(Date:8/28/2014)... SunTrust Robinson Humphrey (STRH) today announced the ... research team in biotechnology and oilfield services.  ... demonstrates our commitment to providing our valued institutional ... decision making," said Biff Woodruff , Head ... significant investments in differentiated content at a time ...
Breaking Biology Technology:Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3
... Biotech Inc. (TSX: ONC, NASDAQ: ONCY ) ... Pandha of the Royal Surrey County Hospital, U.K., was ... Clinical Cancer Research. The paper is entitled "Synergistic Effects ... Melanoma." , The research demonstrated that the innate cancer ...
... , , RICHMOND, Va., Sept. ... fourth year in a row, according to an annual survey published ... brand follows recent No. 1 rankings from Pollina Corporate Real Estate ... rankings by all three of these reputable business brands at one ...
... , , ATLANTA, Sept. 24 ... (the "Company"), an Atlanta-based, biopharmaceutical company developing human vaccines for ... announcement today of partial success in the recently completed Phase ... by Sanofi-Aventis and Global Solutions for Infectious Diseases. The completed ...
Cached Biology Technology:Oncolytics Biotech(R) Inc. Announces Reovirus and Cisplatin Research Supports U.S. Phase 2 Metastatic Melanoma Trial 2Virginia Now Owns Three Top National Business Rankings 2Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 2Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 3Encouraging HIV/AIDS Vaccine Trial Results Support GeoVax Labs, Inc. Strategy 4
... ISO 9001:2000 Certified USDA Research Registered ... SOP's Training AALAS Certified Technicians ... Procedures GLP Documentation Upon Request Focus ... point for all your custom immunology service ...
... XL provides balance data collection and automation that ... integration with Microsoft Excel , Pre-configured library ... , New balances can be added and configured ... from multiple balances into one spreadsheet ...
...
... With increasing age, the autofluorescent ... of many cell types, including neurons. ... complicate the use of fluorescence microscopy ... of its broad excitation and emission ...
Biology Products: