Navigation Links
U-M researchers find key interaction that controls telomeres
Date:2/16/2010

ANN ARBOR, Mich. In the dominoes that make up human cells, researchers at the University of Michigan Comprehensive Cancer Center have traced another step of the process that stops cells from becoming cancerous.

It starts with the enzyme telomerase, which affects the caps, or telomeres, at the end of a chromosome. Telomeres shorten over time. But telomerase prevents this from happening, making the cell immortal. If cancer is triggered in the cell, the presence of telomerase leads to the growth of the cancer.

Telomerase is kept in control by the protein TRF1, which keeps the telomeres operating correctly. But another protein, Fbx4, can bind to TRF1 and degrade it, causing the telomeres to lengthen.

Now, researchers have discovered, a third protein, TIN2, can step in and override Fbx4 by binding to TRF1 first and preventing Fbx4 from attaching to it.

This finding paves the way for developing a drug that acts like TIN2, keeping everything in check and stopping the first domino from falling.

Results of the study appear in the Feb. 16 issue of Developmental Cell.

"In 90 percent of cancers, no matter what caused the cancer to form, it needs telomerase activity to maintain the cell. Without telomerase, the cell will die. Our work is key to understanding a detailed mechanism for how these molecules interact and how to design a drug to block Fbx4," says senior author Ming Lei, Ph.D., assistant professor of biological chemistry at the University of Michigan Medical School.

The researchers found that the location in the molecule where Fbx4 binds to TRF1 overlaps with where TIN2 binds to TRF1. Where both Fbx4 and TIN2 are present, the TIN2 wins out and binds to the TRF1 first. This blocks Fbx4 from binding to the TRF1, thereby stabilizing TRF1 and keeping the telomere length in control.

The researchers are now looking at peptides that mimic TIN2's binding to TRF1, in order to block Fbx4. The
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
U-M researchers find key interaction that controls telomeres
(Date:7/21/2014)... 21, 2014 (Toronto) As part of a multinational, ... Mental Health (CAMH) have helped identify over 100 locations ... developing schizophrenia, in what is the largest genomic study ... published online in Nature , point to biological ... lead to new approaches to treating the disorder, which ...
(Date:7/21/2014)... and Dr. Mary Lou Applewhite Distinguished Professor in Department ... to an article in the scientific journal Nature ... into Primate Biology and Evolution," published on July 20. ... mobile elements that move by a sort of "copy ... important because it is the first "New World" monkey ...
(Date:7/21/2014)... high health risk warning for Yellowknife and surrounding area ... forest fires. Currently 160 wildfires are burning across ... since these fires are endangering people or property. ... with mixed results. The rains help to dampen ... , This year the Northern Territories have seen 855,000 ...
Breaking Biology News(10 mins):International team sheds new light on biology underlying schizophrenia 2International team sheds new light on biology underlying schizophrenia 3LSU's Mark Batzer contributes to Nature Genetics article on marmoset genome 2
... - one that is common to many cancers and affects the ... gene on the X chromosome called UTX - is found in ... UTX plays a role in overall regulation of the activity ... similar roles will also be found to be involved in different ...
... Data in Transit from Capture Point Protects Privacy of ... BIO-key International, Inc. (OTC Bulletin Board: BKYI), ... safety, announced today that the U.S. Patent and Trademark ... "Trusted Biometric Device," which covers a simple, yet secure ...
... affect aging? What can we do to avert the looming ... diseases caused by a rapidly expanding elderly population? How do ... face of inevitable decline? How does exercise enhance memory function? ... focus of the inaugural conference of the Brandeis Lifespan Initiative ...
Cached Biology News:Getting down to cancer basics 2Getting down to cancer basics 3BIO-key(R) Granted Patent for Trusted Biometric Device Security Solution 2BIO-key(R) Granted Patent for Trusted Biometric Device Security Solution 3Living long, living well 2
(Date:7/22/2014)... Holomic is expanding its portfolio ... its fluorescent immunoassay reader, the HRDR-300, at the ... Chicago, July 28-31, 2014. Available in both portable ... is a highly sensitive, low-cost fluorescent reader that ... flow immunoassays with high sensitivity and accuracy. , ...
(Date:7/22/2014)... July 22, 2014 The next session ... 9th, 2014 and will comprise of the increasingly popular ... The TechTrainings is a series of technical hands-on classes ... help them reach the next step in their professional ... is taught by Jennifer Kang, Senior Statistician at Genentech ...
(Date:7/21/2014)... 21, 2014 With a larger, ... the new Cole-Parmer® Digital Gear Pump Drive ... to operate for automated process applications. , Simply ... The batch count function counts down and displays ... tracks amount dispensed across multiple cycles. View the ...
(Date:7/21/2014)... yield so far is small, but chemists at the ... substitution process to make a precursor to transparent thin ... energy devices. , A paper describing the approach is ... of the journal Inorganic Chemistry , which draws ... nuclear chemistry fields. The paper was chosen by the ...
Breaking Biology Technology:Holomic to Debut HRDR-300 Fluorescent Immunoassay Reader at the AACC 2014 2Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 2Clinovo TechTrainings: Next Session of SAS and CDISC Classes Start 9th September, 2014 3New Easy-View Cole-Parmer Digital Gear Pump Drive Makes Performance Monitoring Effortless 2Oregon chemists eye improved thin films with metal substitution 2
... Madison, Wis. SecurePipe, Inc. , a Madison-based ... it raised $3.2 million in funding from First ... Opportunity Fund . The financing will be used to ... recruitment and customer service. , ,The demand for managed ...
... campus, professors work to impart the theory and the ... for many professions, skill with information technology is key ... the School of Library and Information Studies (SLIS) at ... SLIS train students to organize and manage information. Theoretically, ...
... technology company requires insight, discipline, and a relentless focus ... startups create a high-value company by defining a big ... development of new products. Neah Power Systems ... this methodology. , ,Neah is a successful ...
Cached Biology Technology:Closing the IT gap 2Neah Power Systems A seed stage venture capital model 2Neah Power Systems A seed stage venture capital model 3Neah Power Systems A seed stage venture capital model 4Neah Power Systems A seed stage venture capital model 5
... choice of PDMS Stamps (3 PDMS micropatterned ... micron squares or 100 um x 10 ... lines, 3 PDMS nano-patterned stamps with depth ... pitch of 400 nm, or 3 PDMS ...
Request Info...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
... REact Buffers are supplied as 10X concentrated solutions. ... of each of the REact buffers and one ... SetConsists of four 1 ml vials of REact ... 2 Buffer four 1 ml vials of REact ...
Biology Products: