Navigation Links
U-M researchers ID gene involved in pancreatic cancer
Date:3/2/2009

ANN ARBOR, Mich. Researchers from the University of Michigan Comprehensive Cancer Center have identified a gene that is overexpressed in 90 percent of pancreatic cancers, the most deadly type of cancer.

Expression of the gene, Ataxia Telangiectasia Group D Complementing gene, called ATDC, is on average 20 times higher in pancreatic cancer cells than in cells from a normal pancreas. What's more, the gene appears to make pancreatic cancer cells resistant to current therapies.

"One of the challenges in pancreatic cancer is that it is biologically aggressive and it does not respond well to chemotherapy or radiation. We found that ATDC not only causes the cancer cells to grow faster and be more aggressive, but it also makes the cancer cells particularly resistant to chemotherapy and radiation. By targeting this gene, we may be able to make cancer cells more sensitive to the therapies we already have in hand," says senior study author Diane Simeone, M.D., director of the Multidisciplinary Pancreatic Cancer Clinic at the U-M Comprehensive Cancer Center.

Results of the study appear in the March issue of Cancer Cell.

The researchers injected into mice tumor cells expressing ATDC and compared that to a separate group of mice injected with tumor cells in which ATDC was suppressed. In the ATDC-expressing group, tumors grew in all the samples and were significantly larger and starting to metastasize, or spread. In the group in which ATDC was not expressed, only minimal signs of tumor growth were seen after 60 days.

"This particular gene promotes the biologic aggressiveness of the cancer," says Simeone, who is also Lazar J. Greenfield Professor of Surgery and Molecular & Integrative Physiology at the U-M Medical School.

In addition, the researchers found that ATDC is most highly expressed at the point when pre-cancerous cells become malignant. ATDC was also linked to increased levels of a signaling protein call
'/>"/>

Contact: Nicole Fawcett
nfawcett@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. U of MN researchers discover noninvasive diagnostic tool for brain diseases
6. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
7. Researchers discover new strategies for antibiotic resistance
8. Researchers find new taste in fruit flies: carbonated water
9. Binghamton University researchers investigate evolving malaria resistance
10. UIC researchers find promising new targets for antibiotics
11. Researchers develop simple method to create natural drug products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small ... Brands report showed that planet-wide, transactions at merchants on the ... the total number of credit, debit, and prepaid cards reached ... were victims of fraudulent card usage in 2012, and credit ...
(Date:1/22/2015)... NEW YORK , Jan. 22, 2015   EyeLock, Inc. ... announced it has appointed Steve Gerber to the ... Gerber will be responsible for leading development of mobile platforms ... 25 years of success and innovation in the semiconductor industry ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... Tuesday, Nov. 16, 2010 Tying in with ... new pre-conference workshops will debut at this year,s TERMIS-North ... Orlando, Fla. The TERMIS (Tissue Engineering & ... by the Wake Forest Institute for Regenerative Medicine, and ...
... brink of an era of mass extinctions similar to ... disappeared from the Earth, reports a biologist at Penn ... a species-rescue program for Haiti,s threatened frogs and other ... few decades, many Haitian species of plants and animals ...
... SAN DIEGO New research indicates that the ... About two percent of the population has a condition called ... are experienced at once. Although this condition is rare, the ... sometimes overlapping ways to help people interpret and understand their ...
Cached Biology News:Regenerative medicine workshops to debut at TERMIS North America Annual Conference 2Rescue missions underway to save Haiti's species from mass extinctions 2Rescue missions underway to save Haiti's species from mass extinctions 3Rescue missions underway to save Haiti's species from mass extinctions 4Rescue missions underway to save Haiti's species from mass extinctions 5Hearing colors, seeing sounds: New research explores sensory overlap in the brain 2
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces the ... office space for Shire a leading biopharmaceutical company, at Two ... | RBJ,s Robert Richards , president, and Brian ... for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... OH (PRWEB) January 22, 2015 Crystal Diagnostics ... today that it has received AOAC-PTM Certifications for the six ... O121, and O145; collectively referred to as STEC or the ... 1 colony forming unit (cfu) per 325 g of raw ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
(Date:1/22/2015)...   Cypher Genomics, Inc., the leading genome ... SQNM ), the leading molecular diagnostics company, today ... prenatal tests (NIPT). Through this agreement, Sequenom will ... advance analysis of clinically-relevant fetal sub-chromosomal variants detected ...
Breaking Biology Technology:Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Crystal Diagnostics Awarded AOAC-PTM Accreditation for the Rapid Detection of “Big 6” E.coli Food Pathogens 2Global Compliance Service for Controlled Substances to Expand to China 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4
... Neuftec,Limited, the proprietor of the original nano-particulate ... claim against Oxonica Energy,Limited, a wholly owned subsidiary ... in the High Court of Justice, has commented ... by Dr Matthews,(CEO) on 19 June 2008., ...
... have invented an affordable technique that uses lasers and ... needed for new generations of microchips. , The ... times narrower than a human hair, may enable the ... applications in medicine, optical communications, computing and sensor technologies. ...
... June 18 ,Exelixis, Inc. (Nasdaq: EXEL ) announced ... officer at Exelixis, will present at the,Piper Jaffray Europe ... time on Wednesday, June 25, 2008. Mr. Karbe will ... The presentation will be webcast and may be ...
Cached Biology Technology:Neuftec Responds to a Fundamental Inaccuracy in Oxonica PLC's Regulatory Announcement 2Trap and zap: Harnessing the power of light to pattern surfaces on the nanoscale 2Trap and zap: Harnessing the power of light to pattern surfaces on the nanoscale 3
Formula variant: With macro- and micronutrients. Physical Form: powder Suitab tst: plant cell culture tested...
... Analyzer for superior sensitivity, mass accuracy, and resolving power., Specifications:, ... ion selection range: 150 - 4000 m/z, * Resolution: 14,000 (1400 ... * Dynamic range: 4 orders of magnitude ... ...
... PHD2000 syringe pump series combines Harvard Apparatuss best ... and a wide range of configuration options. A ... dimensions of syringes from all the major manufacturers. ... all the pertinent information from across the lab. ...
Mouse monoclonal antibody to RAD51L3 - RAD51-like 3 (S. cerevisiae)...
Biology Products: