Navigation Links
U Alberta-led team studies T cell activation with nanoparticles
Date:4/28/2010

A University of Alberta-led research team has taken a major step forward in understanding how T cells are activated in the course of an immune response by combining nanotechnology and cell biology. T cells are the all important trigger that starts the human body's response to infection.

Christopher Cairo and his team are studying how one critical trigger for the body's T cell response is switched on. Cairo looked at the molecule known as CD45 and its function in T cells. The activation of CD45 is part of a chain of events that allows the body to produce T cells that target an infection and, just as importantly, shut down overactive T cells that could lead to damage.

Cairo and his team are using nanotechnology to study how individual molecules interact in live cells. The method allows them to view the movement of these molecules at nanometre scale, so they can "see" the molecular interaction. To see the movement of a protein, researchers labeled the molecules with nanoparticles and then observed the particles using a microscope. This study is the first to analyze CD45 this way, but the most important advance is their observation of how CD45 interacts with other molecules in the cell to carry out its function.

The team found that CD45 is tethered to the cell cytoskeleton, a meshwork of proteins that gives the cell its shape and structure. They also observed how particular proteins hold CD45 onto the cytoskeleton.

"It's one thing to observe molecular binding in a test tube," said Cairo. "It's quite another to see how the process happens in a live cell." Cairo says a better understanding of the immune regulator CD45 could eventually lead researchers to a point where they can use it as a way to control T cells.

"You could imagine that if you knew when CD45 was turned on or how each molecular partner helps it work, you might be able to take advantage of that and design an inhibitor," said Cairo. "Of course, that's a long way off; at this point, we're trying to understand the molecular mechanisms involved."


'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Related biology news :

1. Poultry research leads to breakthrough in genetic studies of animal domestication
2. New studies help establish potential of artificial liver support devices
3. Solar energy production has enormous potential in southeastern Ontario: Queens University studies
4. Gene studies lead to kissing cousins
5. First studies of fossil of new human ancestor take place at the European Synchrotron
6. Census data aid disease simulation studies
7. Studies provide more support for health benefits of coffee
8. Studies on nutrients, gene expression could lead to tailored diets for disease prevention
9. Mineral studies advance antibacterial alternatives
10. New studies reveal downstream processes of ion channel inactivation
11. Engineer studies tensional integrity of biological structures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2016)... Calif. , March 3, 2016  FlexTech, a ... the categories of Innovation, Research & Development, Leadership in ... Leadership. This is the 9 th year of ... group of companies and individuals from past years ... based on a pre-described set of criteria, by a ...
(Date:3/3/2016)... SOTO, Kansas , March 3, 2016 ... Oncimmune,s Early CDT®-Lung, a blood test to aid ... cancer Early CDT®-Lung test to its clients ... Early CDT®-Lung test to its clients which include ... a leader in early cancer detection, today announced a ...
(Date:3/2/2016)... , March 2, 2016 ... of the "Global Biometrics as a ... offering. --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> Research and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ...
Breaking Biology News(10 mins):
(Date:5/3/2016)... WOODLANDS, Texas , May 3, 2016  Dr. ... certified plastic surgeon in The Woodlands, Texas ... that destroys 24 percent of treated fat cells in ... and woman. Close to 90 percent of Americans report ... treatment options. Nonsurgical fat reduction procedures are a growing ...
(Date:5/2/2016)... ... ... StarNet Communications Corp, ( http://www.starnet.com/ ) a leading publisher of remote Linux ... to its flagship X-Win32 PC X server. The new modules enable X-Win32 to ... over encrypted SSH. , Traditionally, users of PC X servers deploy the XDMCP protocol ...
(Date:4/29/2016)... 2016 According to a ... "Separation Systems for Commercial Biotechnology Market - Global ... 2015 - 2023", the separation systems for commercial ... in 2014 and is projected to expand at ... to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/28/2016)... PUNE, India , April 28, 2016 ... PT, JT, Stirling, and Brayton Cryocoolers), Service (Technical Support, ... Application, and Geography - Global Forecast to 2022", published ... to USD 2.94 Billion by 2022, at a CAGR ... Browse 70 market data Tables and 94 Figures spread ...
Breaking Biology Technology: