Navigation Links
U. Iowa team investigates function of 'junk DNA' in human genes
Date:2/28/2011

edicine and the UI College of Engineering. "Our new study says they do - they affect protein production by altering the efficiency with which messenger RNA is translated into protein."

Xing noted that in other circumstances, altering the rate of protein production can cause disease, meaning that a mechanism that can affect protein production can have a real impact on the characteristics of an organism.

"This would not be the only mechanism that might differentiate humans from other primates, but our study suggests that the creation of new exons from Alu elements is an important process that contributes to those differences," Xing said.

The UI team, including co-first authors Shihao Shen, doctoral student in the Department of Biostatistics; and Lan Lin, Ph.D., associate in the Department of Internal Medicine, made use of data from a new technology called high throughput RNA sequencing to analyze more than 120 million RNA sequences from human cerebellum. Using this data, the team was able to quantify how often Alu-derived exons were included in the mature RNA sequences, which provide the final blueprint for protein production, and where they were inserted in the genes.

"What we found is that these exons tend to avoid protein-coding regions of the genes and rather they end up in the non-coding region that precedes the protein-coding region, called the five prime untranslated region or 5' UTR," Xing explained. "This is the part of the gene that usually contains regions that help control the stability of the messenger RNA and the efficiency at which the messenger RNA is translated into protein."

Experiments to probe the function of these newly inserted elements proved that Alu exons in this region are able to alter the efficiency of messenger RNA translation, which means they affect how fast protein is produced from the altered genes.

The study also suggests that the effect of the newly created exons might be amplifi
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New Naked Scientists series investigates our oceans
2. K-State research team investigates mutated genes role in breast cancer
3. Out of this world: New study investigates infection of human cells in space
4. Rapid response team investigates coral disease outbreak in Kaneohe Bay, Oahu
5. International expedition investigates climate change, alternative fuels in Arctic
6. TECNALIA investigates advanced biomaterials to make more reliable and hardwearing medical implants
7. Researchers achieve a full film frame of a family of proteins essential for cell function
8. Keck Foundation funds work on tiny, implantable computers to restore lost brain functions
9. Just in time for Valentines Day: UNC researchers identify a gene critical for heart function
10. Nitrate improves mitochondrial function
11. Vitamin D deficiency associated with reduced lung function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2015)... N.C. , Feb. 5, 2015  Marken is ... logistics company and has launched a new marketing campaign ... Logistics Organization (CLO).  The new campaign focuses on ... patient, protocol and shipments. The first headline ... , aligns Marken,s priorities with its client,s priorities. Marken ...
(Date:2/5/2015)... , Jan. 27, 2015   Marvin ... globally deployed, innovative test solutions for military, ... delivery of its TS-323 GENASYS Test ... Company (LMSSC). GENASYS is a high-performance PXI-based ... mission-critical applications that require performance functional testing. ...
(Date:2/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/6lngtl/global_biometrics ) ... Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, ... their offering. , In global ... anticipated to overtake North America ... towards IT security, government biometric based projects such ...
Breaking Biology News(10 mins):Marken Launches New Patient-Centric Campaign 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3
... landmark genetic study has identified multiple genes linked to ... disease that affects an estimated 1.4 million Americans. ... brain and blood and occurs in about 31 out ... likely than men to develop the condition, which is ...
... from the January issue of Mayo Clinic Proceedings include ... workplace drug screening and the safety and effectiveness of ... Examine the Effect of Antioxidant Supplements on Cancer ... cancer and deaths related to cancer? Thats a question ...
... The National Academy of Sciences, Sackler Colloquium series ... These networks represent the genomic program for ... cell types. The meeting will focus on ... early embryonic development; gene networks later developmental processes; ...
Cached Biology News:Steps toward Stopping Autoimmune Disease 2Mayo Clinic Proceedings January tip sheet 2Mayo Clinic Proceedings January tip sheet 3
(Date:3/5/2015)... March 5, 2015  In response to the incorrect ... Miami, FL on February 12, 2015. Impeto ... strong financial health and their SUDOSCAN® devices have been ... indicated. Furthermore, Impeto prefers to have the courts decide this ... more than 40 articles written by Key Opinion Leaders, ...
(Date:3/5/2015)... 2015 The next implants made from ... CE mark (European) approval. The CE mark is necessary ... (EFTA) and the European Union. Following the Class IIb ... to implants supplied by the Turkey-based company Osimplant for ... Osimplant's Cervical Expandable Bladed HA PEEK Cage line of ...
(Date:3/4/2015)... INCLINE VILLAGE, Nev. , March 4, 2015 PDL ... that the adjusted conversion rate for the: , ... Notes), is 174.8506 shares of common stock per $1,000 principal ... The conversion rate for the note is adjusted ... be paid on March 12, 2015, to all stockholders who own ...
(Date:3/4/2015)... The UPMC Center for Health Security today ... Emerging Leaders in Biosecurity Initiative (ELBI). As part of ... of biosecurity, UPMC has selected 28 US and international ... backgrounds, including biological science, medicine, policy, the military, think ... the vision and support of the Defense Threat Reduction ...
Breaking Biology Technology:Impeto Medical Responds to Published Allegations by LD Technology LLC ("LD") 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 2Invibio’s PEEK-OPTIMA® HA Enhanced Gains Momentum: New Implant Receives European Approval 3PDL BioPharma Announces Conversion Rate Adjustment for Convertible Note 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3
... trials show that Emulin(TM), a plant-based extract, is better than metformin, ... in human beings. , ... Winter Haven, FL (PRWEB) ... blood sugar levels in Type 2 diabetics better than a leading ...
... Covers Development of Gene Expression Signatures Derived by ... as Molecular Test of Responsiveness to Current Treatments, ... /PRNewswire-FirstCall/,-- Transgenomic (OTC Bulletin Board: TBIO) today announced ... diagnostic test which will guide,clinicians in their choice ...
... Technology Targets Tumors with Precise Image-Guided IMRT to Spare Healthy ... ... ALTO, Calif., Sept. 16 Doctors at cancer,treatment centers in ... neck cancer using RapidArc(TM) radiotherapy technology from Varian,Medical Systems (NYSE: ...
Cached Biology Technology:Human Trial Results Show Plant Extract Tops Drug at Regulating Blood Sugar Levels; Huge Market Seen for Newly Developed Food Additive Emulin™ 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 2Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 3Transgenomic Announces Partnership With Key Genomics for Ovarian Cancer Assay to Guide Therapeutic Options 4Doctors in the US and Netherlands Using Fast RapidArc Radiotherapy Technology to Help Fight Cancer are Now Treating Tumors of the Head and Neck 2Doctors in the US and Netherlands Using Fast RapidArc Radiotherapy Technology to Help Fight Cancer are Now Treating Tumors of the Head and Neck 3
... that it uses a deep-UV deuterium bulb, which ... with a shutter (controlled via a TTL signal ... DH-2000 Deuterium Tungsten Halogen Light Source combines ... light sources in a single optical path. The ...
... pump is a dedicated cuff pump for small ... replaces manual inflation and can be used for ... mouse and rat; from single up to multi-channel ... pump has adjustable cut-off pressure in 50 mmHg ...
... depleted sera are specifically depleted of a ... the depleted protein, the alternative and classical ... therefore ideal for the detection and quantitation ... have been used to assess complement activation ...
... of light production by luciferase-cDNA transfected cell ... technique in the development of reporter gene ... as an indicator for the transcription of ... enzyme is due to advantages such as ...
Biology Products: