Navigation Links
U. Iowa study finds biological link between pain and fatigue
Date:4/7/2008

A recent University of Iowa study reveals a biological link between pain and fatigue and may help explain why more women than men are diagnosed with chronic pain and fatigue conditions like fibromyalgia and chronic fatigue syndrome.

Working with mice, the researchers, led by Kathleen Sluka, Ph.D., professor in the Graduate Program in Physical Therapy and Rehabilitation Science in the UI Roy J. and Lucille A. Carver College of Medicine, found that a protein involved in muscle pain works in conjunction with the male hormone testosterone to protect against muscle fatigue.

Chronic pain and fatigue often occur together -- as many as three in four people with chronic, widespread musculoskeletal pain report having fatigue; and as many as 94 percent of people with chronic fatigue syndromes report muscle pain. Women make up the majority of patients with these conditions.

To probe the link between pain and fatigue, and the influence of sex, the UI team compared exercise-induced muscle fatigue in male and female mice with and without ASIC3 -- an acid-activated ion channel protein that the team has shown to be involved in musculoskeletal pain.

A task involving three one-hour runs produced different levels of fatigue in the different groups of mice as measured by the temporary loss of muscle strength caused by the exercise.

Male mice with ASIC3 were less fatigued by the task than female mice. However, male mice without the ASIC3 protein showed levels of fatigue that were similar to the female mice and were greater than for the normal males.

In addition, when female mice with ASIC3 were given testosterone, their muscles became as resistant to fatigue as the normal male mice. In contrast, the muscle strength of female mice without the protein was not boosted by testosterone.

"The differences in fatigue between males and females depends on both the presence of testosterone and the activation of ASIC3 channels,
'/>"/>

Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-335-9917
University of Iowa
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study finds uncontrollable stress worsens symptoms of endometriosis
2. New study finds anticipating a laugh reduces our stress hormones
3. New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume
4. 1/3 of risk for dementia attributable to small vessel disease, autopsy study shows
5. New study shows that fetal cells to treat Parkinsons disease may not function long term
6. Yale study shows how rare genes have big impact on blood pressure
7. NASA launches airborne study of arctic atmosphere, air pollution
8. Some migratory birds cant find success in urban areas, study finds
9. Study finds concerns with biofuels
10. Veterinary college researcher studying brain tumors in people and animals
11. Statistics are insufficient for study of proteins signal system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
(Date:1/22/2015)... EyeLock, Inc. , a market leader of iris-based identity authentication ... to the new role of Senior Vice President of Mobile ... mobile platforms and wearable solutions for EyeLock,s technologies. Gerber brings ... semiconductor industry to his role at EyeLock, with expertise in ...
(Date:12/22/2014)... Dec. 22, 2014 Research and Markets ... the "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight ... watermarking and fingerprinting markets. Watermarking aims to control ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2The Global Watermarking and Fingerprinting Markets 2
... National Human Genome Center at Shanghai (South Center, hereafter) ... District in Shanghai. To commemorate this important event, ,which ... we specially organize a series of mini-reviews for ,this ... the attention of the Chinese life science research workers ...
... world,s premier science and technology news magazines, released its list ... projects involving physicists from Louisiana Tech University in its Top ... over 5,000 scientists and engineers from 26 nations, ranked #2 ... Markus Wobisch led a team from Louisiana Tech that is ...
... MEETING HIGHLIGHTS BREAKTHROUGH RESEARCH IN UNDERSTANDING GENETIC AND ... Although racial and ethnic differences in ... known, little is understood about the underlying causes ... seemingly intractable problem. The American Association for Cancer ...
Cached Biology News:Human genomics in China 2Human genomics in China 3Human genomics in China 4Human genomics in China 5Human genomics in China 6Human genomics in China 7Human genomics in China 8Human genomics in China 9Human genomics in China 10Human genomics in China 11Louisiana Tech physicists highlight top 10 science stories of 2008 2American Association for Cancer Research hosts Science of Health Care Disparities Meeting 2
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. (NASDAQ: ... areas, announced the closing of an underwritten public offering of ... to an aggregate 3,500,000 shares of common stock, at an ... The warrants have a per share exercise price of $5.00, ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ...
(Date:12/24/2014)... SoundConnect’s 2015 next generation ... communication technology, provide continued education and inform users ... demonstrates online communication features and benefits; empowering users ... innovative and powerful tools. , According to SoundConnect’s ...
(Date:12/24/2014)... Dallas, Texas (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application and ... manufacturing process, and product cost structure. Production is ... also covers upstream raw materials, equipment, downstream client ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... Pulmo BioTech Inc. (OTC Bulletin Board: PLMO; Frankfort ... receive at least $3.3 million pursuant to the ... letter of intent with Biotechnology Consulting Poland Sp. ... Product Candidate PulmoBind(TM) development work, clinical trials and ...
... produced liver cells from adult skin cells using the induced ... the University of Edinburgh,s MRC Centre for Regenerative Medicine, paves ... that can be used for in vitro hepatic disease models. ... cell type used in predictive drug toxicology. These cells are ...
... The scientists and engineers who introduced the world ... the next level of friendly competition designed to ... operations of useful robots whose dimensions are measured ... National Institute of Standards and Technology (NIST), in ...
Cached Biology Technology:Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 2Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 3Pulmo BioTech Inc. Announces Cash Details of its Previously Announced Letter of Intent Intended to Bring its Pulmonary Vascular Diagnostic Product Candidate PulmoBind(TM) to the European Market 4Scientists develop novel method to generate functional hepatocytes for drug testing 2Is your microrobot up for the (NIST) challenge? 2
Imject Freund's Incomplete Adjuvant (FIA)...
... XL extends the MSn performance of the ... tools to generate extensive structural information for ... , Multiple dissociation techniques (PQD, ETD, ... unpredicted metabolites , Fast polarity switching for ...
... effective - Utilizes hands-off homogenization through a vortex ... grinding - Extract DNA without hand grinding; eliminating ... , Robust tubes - Includes tough ... tube breakage , Flexible format - ...
... The LXQ linear ion trap mass ... paced analytical laboratory., The LXQ linear ion ... discovery and proteomic applications, delivering the fast ... Thermo linear ion trap at an attractive ...
Biology Products: