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U. Iowa research team finds new genetic cause of blinding eye disease
Date:8/9/2011

e from the iPSC work validated the role of this genetic mutation in retinal disease. Showing that retinal cells generated from the affected patient could not make the mature retinal MAK protein provided strong evidence of the pathophysiologic mechanism of this mutation in RP," Tucker explained.

Based on the new work, the UI team hopes to explore gene therapy and cell replacement strategies as potential therapies for this form of RP.

The study was funded in part by grants from the National Eye Institute, National Institutes of Health New Innovator Award program and the Foundation Fighting Blindness.

"We are excited to see the University of Iowa and its collaborators bringing together several different research modalities, including genetics and stem cells, to save vision," said Stephen Rose, Ph.D., chief research officer, Foundation Fighting Blindness. "Their innovation and teamwork are greatly accelerating the development of treatments which our constituents are depending on."


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Contact: Jennifer Brown
jennifer-l-brown@uiowa.edu
319-356-7124
University of Iowa Health Care
Source:Eurekalert

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