Navigation Links
Type 2 diabetes study to examine role amylin plays in disease
Date:8/29/2013

WASHINGTONA George Washington University researcher will receive $1.3 million over the next five years from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for research that will help better understand how type 2 diabetes develops, possibly informing the development of novel treatments to reverse the disease.

The research is particularly important given 150 million people worldwide suffer from type 2 diabetes--a number expected to double over the next 20 years.

Aleksandar Jeremic, an associate professor of biology in the Columbian College of Arts and Sciences, along with a team of GW undergraduate students, graduate students and postdoctoral fellows, will study the role amylin--a hormone that, like insulin, is secreted by the pancreas to regulate blood sugar levels--plays in the development of type 2 diabetes. When amylin aggregates in the pancreas and forms protein deposits, it can kill insulin-producing beta-cells, leading to type 2 diabetes.

Using high-resolution imaging approaches such as confocal and atomic force microscopy, which can produce a scan at the nanometer resolution, the GW team will investigate the molecular and biochemical events that lead to the aggregation of human amylin.

"We know of many factors, such as poor diet and inactivity, that contribute to type 2 diabetes," Dr. Jeremic said. "What is less clear, but no less important, is the role amylin plays in the development of the disease. Our research may also provide a better understanding of the biological role of this important signaling molecule in the human body."

Ultimately, the information could contribute to new treatments for type 2 diabetes, for example, by preventing the aggregation of amylin or making cells less susceptible to the toxic effects of the buildup.

The project, "Molecular Mechanisms of Amylin Trafficking and Toxicity in Human Pancreatic Islets," NIH grant R01DK091845, will be funded by the NIDDK, part of the National Institutes of Health, for the next five years.


'/>"/>

Contact: Kurtis Hiatt
kkhiatt@gwu.edu
202-994-1849
George Washington University
Source:Eurekalert

Related biology news :

1. ITN type 1 diabetes study identifies subset of patients with strong response to therapy
2. Obesity and mortality association differs between individuals with and without diabetes
3. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
4. Diet additions may help youth with type 1 diabetes keep producing own insulin
5. DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
6. Infants food linked to higher, lower Type 1 diabetes risk
7. Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use
8. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
9. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
10. New data on islet autoantibodies in young children defines early type 1 diabetes development
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... 2016   Neurotechnology , a provider ... technologies, today released FingerCell 3.0, a software ... that run on low-power, low-memory microcontrollers. FingerCell ... than 128KB of memory, enabling it to ... limited on-board resources, such as: mobile phones, ...
(Date:11/22/2016)... 2016 According to the new market research report ... Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), ... market is expected to grow from USD 10.74 Billion in 2015 to ... 2016 and 2022. Continue Reading ... ...
(Date:11/17/2016)... , Nov. 17, 2016 Global Market Watch: ... Biobanks (Disease-Based Banks, Population-Based Banks and Academics) market is to ... for Private Biobanks shows the highest Compounded Annual Growth Rate ... region during the analysis period 2014-2020. North ... of 9.95% followed by Europe at ...
Breaking Biology News(10 mins):
(Date:12/8/2016)... OXFORD, England , December 8, 2016 /PRNewswire/ ... (OGT), das Unternehmen für Molekulargenetik, erweitert seine Palette ... SureSeq myPanel™ NGS Custom FH Panels, das ein ... Hypercholesterinämie (FH) ermöglicht. Das Panel bietet eine Erkennung ... Number Variations (CNV) mit einem einzigen kleinen Panel ...
(Date:12/8/2016)... ... December 08, 2016 , ... KBioBox ... response to client demand KbioBox developed a sophisticated “3 click” gene dditing off ... accessible from KBioBox’s new website, https://www.kbiobox.com/ and powered by the ...
(Date:12/8/2016)... ... ... This CAST literature review and report looks at problems caused by the current ... in countries that are major global commodity exporters and importers, which show that asynchrony ... level presence (LLP) puts large volumes of trade worth billions of dollars at risk. ...
(Date:12/8/2016)... TAMPA, Fla. , Dec. 8, 2016 /PRNewswire/ ... biopharmaceutical company that discovers, develops and plans to ... today that its shares of common stock were approved ... stock will begin trading on the OTCQX, effective ... To qualify for the OTCQX market, companies must ...
Breaking Biology Technology: