Navigation Links
Type 2 diabetes study to examine role amylin plays in disease
Date:8/29/2013

WASHINGTONA George Washington University researcher will receive $1.3 million over the next five years from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for research that will help better understand how type 2 diabetes develops, possibly informing the development of novel treatments to reverse the disease.

The research is particularly important given 150 million people worldwide suffer from type 2 diabetes--a number expected to double over the next 20 years.

Aleksandar Jeremic, an associate professor of biology in the Columbian College of Arts and Sciences, along with a team of GW undergraduate students, graduate students and postdoctoral fellows, will study the role amylin--a hormone that, like insulin, is secreted by the pancreas to regulate blood sugar levels--plays in the development of type 2 diabetes. When amylin aggregates in the pancreas and forms protein deposits, it can kill insulin-producing beta-cells, leading to type 2 diabetes.

Using high-resolution imaging approaches such as confocal and atomic force microscopy, which can produce a scan at the nanometer resolution, the GW team will investigate the molecular and biochemical events that lead to the aggregation of human amylin.

"We know of many factors, such as poor diet and inactivity, that contribute to type 2 diabetes," Dr. Jeremic said. "What is less clear, but no less important, is the role amylin plays in the development of the disease. Our research may also provide a better understanding of the biological role of this important signaling molecule in the human body."

Ultimately, the information could contribute to new treatments for type 2 diabetes, for example, by preventing the aggregation of amylin or making cells less susceptible to the toxic effects of the buildup.

The project, "Molecular Mechanisms of Amylin Trafficking and Toxicity in Human Pancreatic Islets," NIH grant R01DK091845, will be funded by the NIDDK, part of the National Institutes of Health, for the next five years.


'/>"/>

Contact: Kurtis Hiatt
kkhiatt@gwu.edu
202-994-1849
George Washington University
Source:Eurekalert

Related biology news :

1. ITN type 1 diabetes study identifies subset of patients with strong response to therapy
2. Obesity and mortality association differs between individuals with and without diabetes
3. Healthrageous, United BioSource And Boehringer Ingelheim Launch SMART Digital Diabetes Study
4. Diet additions may help youth with type 1 diabetes keep producing own insulin
5. DNA abnormalities may contribute to cancer risk in people with type 2 diabetes
6. Infants food linked to higher, lower Type 1 diabetes risk
7. Type 2 diabetes patients transplanted with own bone marrow stem cells reduces insulin use
8. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
9. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
10. New data on islet autoantibodies in young children defines early type 1 diabetes development
11. Breakthrough research of essential molecule reveals important targets in diabetes and obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... TEANECK, N.J. , May 16, 2017  Veratad ... leading provider of online age and identity verification solutions, ... the K(NO)W Identity Conference 2017, May 15 thru May ... Ronald Regan Building and International Trade Center. ... across the globe and in today,s quickly evolving digital ...
(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/11/2017)... DUBLIN , Apr. 11, 2017 Research ... Tracking Market 2017-2021" report to their offering. ... The global eye tracking market to grow at ... The report, Global Eye Tracking Market 2017-2021, has been prepared based ... report covers the market landscape and its growth prospects over the ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... 2017 , ... For the months of May and June, ... series on “Cell Therapy Regulation” for its regenerative medicine followship. The ... regulatory challenges of stem cell medical research. , Stem cell clinical trials present ...
(Date:6/22/2017)... ... , ... Charm Sciences, Inc. is pleased to announce that its Charm Amphenicol ... as a screening test at dairies and farms for raw commingled cow milk. The ... EZ Lite system. These systems are a combination incubator and reader in one. , ...
(Date:6/20/2017)...  Kibow Biotech Inc., a pioneer in developing "Enteric ... a new patent covering a unique method for preventing ... and Trademark Office on May 23 rd 2017. ... Bio award in 2014 in San Diego, ... to chronic disease. Renadyl™, the first and only dietary ...
(Date:6/19/2017)... ... 2017 , ... As Vice President, Product Services, Mr. Guinter ... support, and client process and SOP development. , Mr. Guinter brings a wealth ... for service providers and top-tier pharmaceuticals, and as an independent consultant supported a ...
Breaking Biology Technology: