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Type 1 diabetes triggered by 'lazy' regulatory T-cells: McGill researchers
Date:1/15/2008

functional potency declined with age, leaving potential autoimmune responses in the pancreas unchecked.

It is likely, the researchers say, that certain genetic predispositions, coupled with the possible contribution of external environmental factors or infections, could potentially alter regulatory T-cell function in susceptible individuals and trigger a full-scale diabetic autoimmune reaction in the pancreas.

Once they start, these immune responses are like a fire that goes unchecked by firemen, or a car going downhill without brakes, said Dr. Piccirillo. Moreover, he said, this discovery not only elucidates the mechanism by which type 1 diabetes is triggered, but it also points the way to the development of new immune system-based therapies for a whole range of diseases.

We believe that these regulatory cells may represent a kind of master switch, and by understanding how they are made, how they function and how they survive, we may be able to stop disease from occurring.


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Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

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