Navigation Links
Two suppressor molecules affect 70 genes in leukemia
Date:4/24/2008

COLUMBUS, Ohio By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.

The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, most of which are involved in critical functions such as cell growth, death, proliferation and metabolism.

The findings reveal how the two molecules, called miR-15a and miR-16-1, normally protect against cancer, and suggest a possible new treatment strategy for CLL.

The study, led by researchers at the Ohio State University Comprehensive Cancer Center, was published recently in the Proceedings of the National Academy of Sciences.

These findings give us a signature of 70 deregulated genes that we believe finally explains at the molecular level how these two molecules contribute to CLL, says principal investigator Carlo M. Croce, director of Ohio States human cancer genetics program.

The identification of these genes could also have important significance for the development of new therapeutic approaches for chronic leukemias.

The two molecules are forms of microRNA, tiny molecules that cells use to help regulate the type and amount of proteins they make.

In 2005, Croce and his colleagues first showed that these two microRNAs target a gene called Bcl2, which normally helps cells survive by protecting them from accidental self-destruction. In CLL, however, the gene behaves abnormally and helps the leukemic cells survive long after they should have died.

Croce and his colleagues believe that loss of the two molecules alters the genes behavior.

For the new study, the investigators first injected mice with leukemia cells in which they had restored the two microRNAs. This completely suppressed tumor growth in three of five animals. Mice injected with leukemic cells that lacked the two molecules, on the other hand, d
'/>"/>

Contact: Darrell E. Ward
darrell.ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bits of junk RNA aid master tumor-suppressor gene
2. Clemson scientists shed light on molecules in living cells
3. New molecules discovered that block cancer cells from modifying cell DNA
4. Curry-derived molecules might be too spicy for colorectal cancers
5. New book presents methods to poke and prod individual molecules
6. Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
7. Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
8. Fast AFM probes measure multiple properties of biomolecules or materials simultaneously
9. Gender, coupled with diabetes, affects vascular disease development
10. Restless legs syndrome affects nearly 2 percent of US/UK children
11. UCR engineers to develop new tool to measure how environmental exposures affect health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... can operate inside the bore of an MRI scanner ... research partnership program at Brigham and Women,s Hospital in ... in conjunction with real-time MRI images, can make prostate ... discomforting for the patient. The novel system also has ... precision. , Developed by a team of robotics engineers ...
(Date:9/18/2014)... starts a "frequent flyers" program, fruit flies surely would ... has hosted increasing numbers of fruit fly research studies. ... in April, and another is scheduled launch to the ... launch in December. , Fruit flies are biomedical research ... space. Model organisms can reveal the basis for health ...
(Date:9/18/2014)... millions of Americans to undertake jaunts into the countryside each ... longer within a century, according to new research. , Climate ... the United States as summer temperatures linger later into the ... Ecology and Biogeography . For instance, the paper birch ... New Hampshire could change color one to three weeks ...
Breaking Biology News(10 mins):Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... Illinois study has shown for the first time that sulforaphane, ... its parent compound by bacteria in the lower gut and ... that we will be able to enhance the activity of ... Elizabeth Jeffery, a U of I professor of human nutrition. ...
... power offers a feasible way for Maryland to help ... and political hurdles, concludes a new study by the ... The study, " Maryland Offshore Wind Development ," ... developing and operating wind farms in Maryland,s Atlantic coastal ...
... landscape of Central Africa 65 million years ago was a ... whether the region,s mammals browsed and hunted beneath the canopy ... tropical rainforest at that time is weak and far from ... in Dallas. Fossil pollen from Central and West Africa ...
Cached Biology News:Discovery may help scientists boost broccoli’s cancer-fighting power 2Offshore wind a 'mixed bag': University of Maryland study 2Offshore wind a 'mixed bag': University of Maryland study 3Evidence is weak for tropical rainforest 65 million years ago in Africa's low-latitudes 2Evidence is weak for tropical rainforest 65 million years ago in Africa's low-latitudes 3
(Date:9/19/2014)... , Sept. 19, 2014  Nektar Therapeutics ... from preclinical studies characterizing the analgesic profiles of ... kappa opioid receptor agonist molecules. The preclinical research ... medicinal chemistry platform. The analgesic properties ... the medical literature. 1,2 Kappa opioid receptors ...
(Date:9/19/2014)... Dublin ... announced the addition of the  "Micro Market Monitor ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... fastest-growing segments in the chromatography market. The market ... expected to reach $2.0 billion by 2019, at ...
(Date:9/18/2014)... , Sept. 18, 2014 About POCT ... is performed outside a clinical laboratory. It helps ... administrating appropriate treatments and medication. POCT is gaining ... of lifestyle diseases such as diabetes, heart disease, ... POCT devices are standardized to minimize errors during ...
(Date:9/18/2014)... Texas Governor Rick Perry, Texas ... Health Science Center CEO Brett Giroir, M.D., and ... Human Services (HHS), State of Texas and biopharmaceutical ... vaccine manufacturing facility in Bryan, Texas, which when ... Texas A&M Biocorridor – a rapidly evolving hub ...
Breaking Biology Technology:Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Micro Market Monitor : Global Pre-packed Chromatography Columns 2POCT Market in China 2014-2018 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4
... March 22, 2011 Practice Fusion ... Analyze This! part of Health 2.0,s Spring Developer Challenge. ... available free through Microsoft,s Windows Azure Marketplace, Epicenter developer ... could help identify and better control the spread of ...
... HAMILTON, N.J., March 22, 2011 VENENUM Biodesign, a ... of its compound collection to identify hits against its ... that it will be exhibiting at the 17th SBS ... and Convention Center in Orlando, Florida, March 27-31, 2011. ...
... new "templated growth" technique for fabricating nanoribbons of epitaxial ... wide that conduct current with almost no resistance. ... devices made with conventional architectures and set the ... advantage of the quantum properties of electrons. "We ...
Cached Biology Technology:Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 2Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 3Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 4VENENUM Biodesign to Exhibit at SBS 2Templated growth technique produces graphene nanoribbons with metallic properties 2Templated growth technique produces graphene nanoribbons with metallic properties 3Templated growth technique produces graphene nanoribbons with metallic properties 4
... (rEK) is a highly purified preparation of ... serine protease which recognizes the identical cleavage ... has similar enzymatic activity (1). Novagen&'s enzyme ... to yield the highest activity available, and ...
... benefits of a Hybridizer and UV Crosslinker (254nm ... , This unique, new design for ... at one location , Hybridizer and Crosslinker ... other , The Crosslinker is also available ...
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... high performance spectral scanning multimode reader ... the advanced SkanIt Software it offers ... discovery assay development. Varioskan provides unlimited ... fluorescence and photometric assays and a ...
Biology Products: