Navigation Links
Two new weapons in the battle against bacteria
Date:2/13/2014

This news release is available in German.

Proteins are made up of a chain of amino acids and are vital for all cell processes. Proteases are among the most important types of protein. Like "molecular scissors", they cut other proteins at given positions and thereby execute important cell functions. By cutting the amino acid chains to the right length or breaking proteins apart they, for example, activate or deactivate proteins, decompose defective ones or switch signal sequences that serve to transport proteins to their proper position within a cell.

But proteases are important not only for human cells bacteria also rely on them. There are hardly any effective antibiotics left in the fight against pathogens like multi-resistant strains of Staphylococcus aureus bacteria or Mycobacterium tuberculosis which causes tuberculosis.

Researchers around the world are thus working ardently to find new ways of disarming the proteases in these strains to combat them. At the heart of this effort lies the so-called ClpP protease. It comprises 14 subunits and has a central regulatory function. The usual approach to deactivating this protease is to block all active centers of the ClpP. These are effectively the "cutting edges of the scissors", i.e. the portions of the protein that are responsible for breaking apart other proteins.

"However, the inhibitors used in the past have one decisive disadvantage," explains Stephan Sieber who heads the Chair for Organic Chemistry II at the Technische Universitaet Muenchen (TUM). "They don't permanently disarm the proteins, but only work for a few hours. On top of that, to be effective they must attack all active centers of the protein."

New strategies against bacteria

In collaboration with
'/>"/>

Contact: Dr. Andreas Battenberg
battenberg@zv.tum.de
49-892-891-0510
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dismantling Syrias chemical weapons in the midst of war
2. Weapons testing data determines brain makes new neurons into adulthood
3. DARPA director: Revolutionary weapons require strong S&T partnerships
4. Nuclear weapons surprising contribution to climate science
5. Effect of chronic exposure to chemicals used as weapons, pesticides under study
6. Poultry probiotics coat clues to ability to battle bugs
7. Battle against resistant bacteria takes huge leap forward
8. Predators vs. alien: European shrimps win predatory battles with an American invader
9. Helper cells aptly named in battle with invading pathogens
10. Tide is turning in skin cancer battle
11. A way of thinking may enable battle but prevent war crimes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Two new weapons in the battle against bacteria
(Date:8/1/2014)... of phloem, the conductive tissue through which plants transport ... cylindrical cells are capped at one end by a ... which in turn form a network throughout a plant,s ... cells which play an important role in carbon sequestration, ... their differentiation," says Professor Yk Helariutta from the Institute ...
(Date:8/1/2014)...  LiveScan Service Provider Binary Biometrics is pleased to welcome ... Biometrics will improve its mobile service capabilities and add more daily appointments, which ... and service several new cities such as, but not limited to, ... , Deltona , Edgewater , ... Smyrna Beach , Oak Hill , Orange ...
(Date:7/31/2014)... Foundation (NSF), counters a widely-held scientific view that ... that certain Arctic lakes store more greenhouse gases ... The study, published this week in the journal ... occur as permafrost thaws and creates surface depressions ... was previously frozen land into lakes. , The ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Certain Arctic lakes store more greenhouse gases than they release 2
... Ore. Severe burn injuries in children have been shown to ... or fat tissues, a new clinical study has found. Stored ... weeks than might normally be possible in years. An analysis ... found they lost almost half of their stored vitamin E in ...
... their geographical ranges away from the equator or to higher ... many plants and animals, the ranges of others seem stable. ... amount of warming, it becomes more difficult for ecologists to ... these effects. In a study published this week in ...
... For the first time, researchers have discovered a disease mechanism ... "sporadic" form of ALS -- and points to a possible ... of publication in the journal Nature Neuroscience . ... motor neurons and death within three to five years of ...
Cached Biology News:Burn injuries rapidly deplete vitamin E 2Burn injuries rapidly deplete vitamin E 3Climate change may create tipping points for populations, not just species 2Link between 2 forms of ALS suggests drug target 2Link between 2 forms of ALS suggests drug target 3
(Date:8/1/2014)... DUBLIN , Aug. 1, 2014 ... the "Global Single Nucleotide Polymorphism (SNP) Genotyping and ... http://photos.prnewswire.com/prnh/20130307/600769 Single ... of genetic variations of SNPs in the genome of ... including humans. SNP genotyping and analysis technology can analyze ...
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
(Date:7/31/2014)... 31, 2014 Food and natural ... searching for food alternatives that offer variety, as ... food ingredient market has numerous players operating in ... Vital Force Technology (VFT). VFT is a ... energetic patterns, all tested to produce stable, effective ...
(Date:7/31/2014)... , July 31, 2014 Nearly 20,000 medical ... Annual Meeting & Clinical Lab Expo in ... featured never-before-seen breakthroughs in diagnostic research and technology that ... need. As of Wednesday, July 30, more ... Annual Meeting & Clinical Lab Expo, with more than ...
Breaking Biology Technology:Global Single Nucleotide Polymorphism (SNP) Genotyping and Analysis Market 2014-2018 2Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3
... Regulatory Affairs Professional Brings More Than Two ... Research Experience, CINCINNATI, Feb. 1 ... full-service clinical research organization, today,announced the hiring ... President, Global,Regulatory and Quality. Dr. Tripathi will ...
... Feb. 1 Gunther von Hagens, BODY WORLDS ... open at the Maryland,Science Center this Saturday, February ... of The Three Pound Gem, a special feature ... 200 anatomical specimens, including,whole bodies, healthy and unhealthy ...
... Corp. (Nasdaq: GENZ ) and Isis Pharmaceuticals, Inc. ... clearance under the,Hart-Scott-Rodino Antitrust Improvements Act for their collaboration, ... approval, Genzyme will pay,Isis $150 million to purchase five ... Upon completion of final contracts, Genzyme will pay ...
Cached Biology Technology:Kendle Hires Satish Tripathi, PhD, RAC as Vice President, Global Regulatory and Quality 2Maryland Science Center Unveils Anatomical Exhibition, Body Worlds 2, on Saturday, February 2 2Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 2Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 3Genzyme and Isis Announce Hart-Scott-Rodino Approval of Collaboration 4
Kit for BASE20/50 dual control unit, includes mounting plate, HOLDER50T, HEATERPAD50, SRTDX temperature probe(s)....
... Situ Assay Kit is a fluorescent-based assay ... undergoing apoptosis. The kit is for research ... or therapeutic procedures. CHEMICON®s CaspaTag™ Pan-Caspase In ... to detect active caspases. The methodology is ...
... This special concentrated jetSI 10 nM ... delivery into mouse brain as described in: ... Alfama, C. Giovannangeli, J.-P. Behr, and B.-A. ... gene expression in the mouse brain at ...
... INTERFERin is a new-generation siRNA transfection reagent ... at 1 nM siRNA in a wide ... excellent cell viability. Using low siRNA concentrations ... observed when transfecting siRNA at higher concentrations, ...
Biology Products: