Navigation Links
Two new studies on circadian rhythms
Date:5/15/2009

Hanover, NHDartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15.

Research on the relationship between clocks and temperature, reported in Cell, offers insight into a longstanding puzzle of temperature compensation: why the 24-hour circadian rhythm does not change with temperature when metabolism is so affected.

A related study, in Molecular Cell, tracks a clock protein in action, mapping hundreds of highly choreographed modifications and interactions to provide the first complete view of regulation across a day.

The new work adds clarity to the molecular underpinnings of circadian clocks, the finely tuned cellular timekeepers that drive most organisms. Circadian systems are biological oscillators that orchestrate activities through an elaborate network of interactive proteins and feedback loops. All clocks rely on transfer of phosphate groups, called phosphorylation, to clock proteins for setting the 24-hour cycle.

Both studies looked at phosphorylation of the frequency (FRQ) clock protein, a central feedback cog in the fungal clock system. They build on the research of team leaders, Drs. Jay Dunlap and Jennifer Loros, who have documented the workings of FRQ and most other components in the Neurospora clock.

"The Cell paper describes how the cell uses phosphorylation of a clock protein to keep the period length of the cycle close to the same across a range of temperatures. This phenomenon, called temperature compensation, is one of the few canonical properties of rhythms that still lack molecular description," said Dunlap.

"The one in Molecular Cell describes collaborative work with Dr. Scott Gerber in the Norris Cotton Cancer Center. We used mass spectrometry to follow the degree of phosphorylation of over 75
'/>"/>

Contact: Sue Knapp
dms.communications@dartmouth.edu
603-650-1492
Dartmouth College
Source:Eurekalert

Page: 1 2

Related biology news :

1. New early detection studies of lung cancer in non-smokers launched today
2. Scripps studies offer new picture of Lake Tahoes earthquake potential
3. Analysis finds strong match between molecular, fossil data in evolutionary studies
4. Peregrines PS-targeting antibodies highlighted in AACR Annual Meeting studies
5. Free online toolkit provides standard measures for genome and population studies
6. GSA special paper presents new studies of Western US earth motion
7. West Nile virus studies show how star-shaped brain cells cope with infection
8. Alzheimers disease therapeutic prevents long-term damage from TBI in pre-clinical studies
9. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
10. New tool for genome-wide association studies
11. Execretion analysis aids primate social studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 22, 2015 Infinisource has launched its ... the G2 model. The G2 sets a higher standard for ... human capital management solution. With plug-and-play installation, touch screen interface ... clock provides a robust time collection solution for the small ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, announces it ... Robbins for the 2015 International CES debut of the ... will be at the NXT-ID booth January 6th and ...
(Date:12/22/2014)... Holiday Season may be the brightest ever for the ... long anticipated floodgates for consumer biometrics may finally be ... tablets, and wearable mobile devices that incorporate biometrics will ... nearly 4.8 billion biometric devices by 2020.   ...
Breaking Biology News(10 mins):Infinisource's NXG series sets new time clock standard 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... DIEGO , Nov. 14, 2013  Shareholder rights law firm ... Vical Incorporated (NASDAQ: VICL ) has filed a ... Court for the Southern District of California.  The complaint alleges ... Securities and Exchange Act of 1934 between February, 8, 2012 ...
... baboons at the Texas Biomedical Research Institute may help ... bisphosphonates are at-risk for atypical fractures in the long ... M. Havill, Ph.D. and colleagues at the Southwest Research ... and found differences in the microstructure of their femurs ...
... resistance is an international reality whose solution includes better ... disease physician. "The big problem is the overuse ... can they lead to side effects like rashes and ... of multidrug-resistant organisms," said Dr. Josѐ A. Vazquez, Chief ...
Cached Biology News:Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action 2New studies may explain fractures in some who take osteoporosis drugs 2Antibiotic resistance is a international issue that better education can address 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was invited to ... on probiotics in San Diego, CA. , The Scripps ... health care professionals. This year’s pre-conference seminar was held on ... Dr. Leyer spoke about the emerging topics and science in ...
(Date:1/22/2015)... , 22 de enero de 2015  El Dr. ... su llamada a nominaciones para 2015. Este prestigioso premio ... o tiene el potencial para hacer, contribuciones destacadas para ... aceptarán hasta el 15 de marzo de 2015 a ...
(Date:1/22/2015)... Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... on advanced wound care, announces that AMNIOEXCEL® and ... been added to the Premier, Inc. Regenerative Skin ... for the AMNIOEXCEL® and AMNIOMATRIX® product lines, which ...
(Date:12/24/2014)... Dec. 24, 2014  Vermillion, Inc. (Nasdaq:   VRML), ... announced today that the Company closed its previously ... Management, Jack W. Schuler , Birchview Fund ... $10.5 million, before offering expenses.  The proceeds will ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... announced today that it has completed patient enrollment ... company,s investigational,once-daily oral anti-cancer drug, for the second-line ... studies -- ZODIAC (ZACTIMA in,cOmbination with Docetaxel In ... Alimta in Lung cancer) -- are the second ...
... DIEGO, March 12 Volcano Corporation,(Nasdaq: VOLC ... and,functional measurement (FM) products designed to enhance the ... said today that it,will be participating in the ... Monday, March 17., The presentation by Scott ...
... March 12 Allergy Standards LTD,("ASL"), the internationally ... its participation at the 2008 American Academy of,Allergy, ... in,Philadelphia, PA March 14th-18th., "The AAAAI conference ... research work in the asthma and allergy spaces," ...
Cached Biology Technology:AstraZeneca Completes Enrollment in Two Pivotal Phase III Studies of the Investigational Drug Vandetanib (ZACTIMA(R)) in Non-Small Cell Lung Cancer (NSCLC) 2AstraZeneca Completes Enrollment in Two Pivotal Phase III Studies of the Investigational Drug Vandetanib (ZACTIMA(R)) in Non-Small Cell Lung Cancer (NSCLC) 3Volcano Corporation Presentation at Cowen Healthcare Conference to be Webcast 2