Navigation Links
Two new studies on circadian rhythms
Date:5/15/2009

Hanover, NHDartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15.

Research on the relationship between clocks and temperature, reported in Cell, offers insight into a longstanding puzzle of temperature compensation: why the 24-hour circadian rhythm does not change with temperature when metabolism is so affected.

A related study, in Molecular Cell, tracks a clock protein in action, mapping hundreds of highly choreographed modifications and interactions to provide the first complete view of regulation across a day.

The new work adds clarity to the molecular underpinnings of circadian clocks, the finely tuned cellular timekeepers that drive most organisms. Circadian systems are biological oscillators that orchestrate activities through an elaborate network of interactive proteins and feedback loops. All clocks rely on transfer of phosphate groups, called phosphorylation, to clock proteins for setting the 24-hour cycle.

Both studies looked at phosphorylation of the frequency (FRQ) clock protein, a central feedback cog in the fungal clock system. They build on the research of team leaders, Drs. Jay Dunlap and Jennifer Loros, who have documented the workings of FRQ and most other components in the Neurospora clock.

"The Cell paper describes how the cell uses phosphorylation of a clock protein to keep the period length of the cycle close to the same across a range of temperatures. This phenomenon, called temperature compensation, is one of the few canonical properties of rhythms that still lack molecular description," said Dunlap.

"The one in Molecular Cell describes collaborative work with Dr. Scott Gerber in the Norris Cotton Cancer Center. We used mass spectrometry to follow the degree of phosphorylation of over 75
'/>"/>

Contact: Sue Knapp
dms.communications@dartmouth.edu
603-650-1492
Dartmouth College
Source:Eurekalert

Page: 1 2

Related biology news :

1. New early detection studies of lung cancer in non-smokers launched today
2. Scripps studies offer new picture of Lake Tahoes earthquake potential
3. Analysis finds strong match between molecular, fossil data in evolutionary studies
4. Peregrines PS-targeting antibodies highlighted in AACR Annual Meeting studies
5. Free online toolkit provides standard measures for genome and population studies
6. GSA special paper presents new studies of Western US earth motion
7. West Nile virus studies show how star-shaped brain cells cope with infection
8. Alzheimers disease therapeutic prevents long-term damage from TBI in pre-clinical studies
9. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
10. New tool for genome-wide association studies
11. Execretion analysis aids primate social studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
(Date:7/25/2014)... era, 100,000s of people lived on the land now ... to control the availability of plants they used for ... use fire to maintain desired habitat and natural resources. ... Service,s Pacific Southwest Station, will lead a field ... during the Ecological Society of America,s 99th Annual Meeting, ...
(Date:7/25/2014)... scientists from 25 countries and 35 states will ... the Genetics Society of America (GSA) next week ... conference will feature close to 500 presentations (including ... including gene expression and regulation, functional genomics, chemical ... and a variety of diseases. , Of ...
Breaking Biology News(10 mins):Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3Fire ecology manipulation by California native cultures 2Fire ecology manipulation by California native cultures 3Yeast meeting to showcase latest breakthroughs in genetics and molecular biology 2
... in a lab that set up small pond ecosystems for experiments ... duplicate pond communities with a given experimental treatment," he says. ... of these species, and eight of the other species, and 15 ... every replicate would do its own thing and nothing would be ...
... When it comes to potentially doubling the output of the ... the spit. Researchers at Cornell University, as well as ... discovered that when a major South American pest infests potato ... this increased yield, they write in the peer-reviewed journal ...
... 2010 News media and others interested in the chemical ... of American Chemical Society (ACS) Webinars, focusing on tips on ... way. Scheduled for Thursday, June 3, from 2 ... "Lindy" Harrison, the instructor for "Effective Technical Writing Short Course" ...
Cached Biology News:The great pond experiment: Regional vs. local biodiversity 2The great pond experiment: Regional vs. local biodiversity 3To double spud production, just add a little spit 2
(Date:7/25/2014)... Amgen (NASDAQ: AMGN ) announced ... per share dividend for the third quarter of 2014. ... to all stockholders of record as of the close ... About Amgen Amgen is committed to unlocking the potential ... discovering, developing, manufacturing and delivering innovative human therapeutics. This ...
(Date:7/25/2014)... WABC Radio show out of New York ... Young will be hosting California-based Vet-Stem, Inc.’s Founder and CEO, ... in pets. Dr. Harman first visited the show in ... for pets suffering from osteoarthritis and other degenerative diseases, as ... forward. , Young has invited Dr. Harman back to dial ...
(Date:7/25/2014)... 25, 2014 At the request of ... a 60-day extension for the public comment period (Docket ... for Model Aircraft established by Congress as part of ... 60-day extension establishes the new deadline for comments as ... of Transportation/FAA notice published in the Federal Register on ...
(Date:7/24/2014)... , July 24, 2014  Now available is ... home. Rehealth Regenerative Therapies , located in ... other physically active people a new health option: ... Regardless of age, countless patients suffer from joint and ... such as muscle tears, torn rotator cuff, tennis elbow, ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 2Robert J. Harman, DVM, Founder and CEO of Vet-Stem, Inc. to Join New York Radio Host Lorry Young in Upcoming Episode of A “Paws” For Your Pet 3FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3
... DIEGO, March 28, 2012 OncoSec Medical Incorporated ... Medical System (OMS) ElectroOncology therapies to treat solid tumor ... institutional investors of an aggregate of 31,000,000 shares of ... registered public offering.  Additionally, investors received Warrants to purchase ...
... 2012 Soligenix, Inc. (OTCBB: SNGX) (Soligenix or the ... financial results for the year ended December 31, 2011. ... December 31, 2011 were $7.7 million as compared to ... revenues was a result of a $5.0 million non-refundable ...
... computer chips are in demand. RUB physicists have discovered ... Dr. Padma Kant Shukla and Dr. Bengt Eliasson found ... charged potential makes it possible to combine positively charged ... this way, current can be conducted much more quickly ...
Cached Biology Technology:OncoSec Closes $7.75 Million Public Offering 2OncoSec Closes $7.75 Million Public Offering 3Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 2Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 3Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 4Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 5Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 6Soligenix Reports Year-End 2011 Financial Results and Highlights Recent Accomplishments 7When ions get closer 2